Sequence Detail

ID/Version

Q99PV5 (UniProt | EBI)

Last sequence update: 2001-06-01
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Class E basic helix-loop-helix protein 41; Short=bHLHe41;AltName: Full=Class B basic helix-loop-helix protein 3; Short=bHLHb3;AltName: Full=Differentially expressed in chondrocytes protein 2; Short=mDEC2;

Provider

SWISS-PROT

Sequence

Polypeptide 410 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Bhlhe41	basic helix-loop-helix family, member e41	42	107	3	7

Sequence references in MGI

J:66944 Fujimoto K, et al., Molecular cloning and characterization of DEC2, a new member of basic helix-loop-helix proteins. Biochem Biophys Res Commun. 2001 Jan 12;280(1):164-71
J:79730 Honma S, et al., Dec1 and Dec2 are regulators of the mammalian molecular clock. Nature. 2002 Oct 24;419(6909):841-4
J:87263 Kawamoto T, et al., A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation. Biochem Biophys Res Commun. 2004 Jan 2;313(1):117-24
J:137262 Nakashima A, et al., DEC1 modulates the circadian phase of clock gene expression. Mol Cell Biol. 2008 Jun;28(12):4080-92
J:151927 He Y, et al., The transcriptional repressor DEC2 regulates sleep length in mammals. Science. 2009 Aug 14;325(5942):866-70
J:180477 Sato F, et al., Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1. Eur J Biochem. 2004 Nov;271(22):4409-19
J:209571 Goriki A, et al., A novel protein, CHRONO, functions as a core component of the mammalian circadian clock. PLoS Biol. 2014 Apr;12(4):e1001839
J:211246 Cho Y, et al., The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors. Mol Pharmacol. 2009 Dec;76(6):1360-9
J:271712 Zhang T, et al., Small Heterodimer Partner Regulates Circadian Cytochromes p450 and Drug-Induced Hepatotoxicity. Theranostics. 2018;8(19):5246-5258