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Mrps34 Gene Detail
Summary
  • Symbol
    Mrps34
  • Name
    mitochondrial ribosomal protein S34
  • Synonyms
    0610007F04Rik, 5330430D13Rik, Tce2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930188
    NCBI Gene: 79044
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:24895120-24896274 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 12.53 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    24 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1930188
protein coding gene Chr17:24895116-24897502 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023331
protein coding gene Chr17:23920447-23922842 (+)
A/J MGP_AJ_G0023291
protein coding gene Chr17:23257236-23259631 (+)
AKR/J MGP_AKRJ_G0023258
protein coding gene Chr17:23345735-23348130 (+)
BALB/cJ MGP_BALBcJ_G0023296
protein coding gene Chr17:23457778-23460173 (+)
C3H/HeJ MGP_C3HHeJ_G0023056
protein coding gene Chr17:23711073-23713468 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023739
protein coding gene Chr17:24983426-24985812 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021214
protein coding gene Chr17:20717469-20719866 (+)
CAST/EiJ MGP_CASTEiJ_G0022558
protein coding gene Chr17:23565613-23568008 (+)
CBA/J MGP_CBAJ_G0023032
protein coding gene Chr17:25827836-25830231 (+)
DBA/2J MGP_DBA2J_G0023161
protein coding gene Chr17:22850073-22852468 (+)
FVB/NJ MGP_FVBNJ_G0023131
protein coding gene Chr17:22570430-22572825 (+)
LP/J MGP_LPJ_G0023238
protein coding gene Chr17:24225710-24228105 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023150
protein coding gene Chr17:25517124-25519519 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023777
protein coding gene Chr17:23630240-23632635 (+)
PWK/PhJ MGP_PWKPhJ_G0022307
protein coding gene Chr17:21605388-21607774 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022125
protein coding gene Chr17:21694542-21696944 (+)
WSB/EiJ MGP_WSBEiJ_G0022621
protein coding gene Chr17:23702809-23705204 (+)



Homology
more
  • Human Ortholog
    MRPS34, mitochondrial ribosomal protein S34
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MRPS34, mitochondrial ribosomal protein S34
    Orthology source: HomoloGene, HGNC
  • Synonyms
    COXPD32, MRPS12, MRP-S12, MRP-S34
  • Links
    NCBI Gene ID: 65993
    neXtProt AC: NX_P82930
    UniProt: P82930

  • Chr Location
    16p13.3; chr16:1771889-1773151 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 32562
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MRPS34
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced mutation exhibit mitochondrial malfunction with cardiac hypertrophy and liver steatosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 79044 NCBI Gene Model | MGI Sequence Detail 1155 C57BL/6J ±  kb
    transcript NM_023260 RefSeq | MGI Sequence Detail 914 C57BL/6  
    polypeptide Q9JIK9 UniProt | EBI | MGI Sequence Detail 218 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1914087, MGI:1924352, MGI:2147008
    References
    more
    • Summaries
      All 29
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 6
    • Earliest
      J:63450 Kargul GJ, et al., Eleven densely clustered genes, six of them novel, in 176 kb of mouse t-complex DNA. Genome Res. 2000 Jul;10(7):916-23
    • Latest
      J:222643 Richman TR, et al., Mutation in MRPS34 compromises protein synthesis and causes mitochondrial dysfunction. PLoS Genet. 2015 Mar;11(3):e1005089

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    last database update
    10/15/2019
    MGI 6.14
    The Jackson Laboratory