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Mrps34 Gene Detail
Summary
  • Symbol
    Mrps34
  • Name
    mitochondrial ribosomal protein S34
  • Synonyms
    0610007F04Rik, 5330430D13Rik, Tce2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930188
    NCBI Gene: 79044
Location & Maps
more
  • Sequence Map
    Chr17:24895116-24897502 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2387 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 12.53 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    MRPS34, mitochondrial ribosomal protein S34
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MRPS34, mitochondrial ribosomal protein S34
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MRPS12, MRP-S12, MRP-S34
  • Links
    NCBI Gene ID: 65993
    neXtProt AC: NX_P82930

  • Chr Location
    16p13.3; chr16:1771895-1773139 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (ENU)
    1
  • Gene trapped
    2
  • Targeted
    1
  • Incidental Mutations
Mice homozygous for an ENU-induced mutation exhibit mitochondrial malfunction with cardiac hypertrophy and liver steatosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030475 VEGA Gene Model | MGI Sequence Detail 2387 C57BL/6J ±  kb
transcript OTTMUST00000075446 VEGA | MGI Sequence Detail 918 Not Applicable  
polypeptide OTTMUSP00000039554 VEGA | MGI Sequence Detail 218 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    31 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000010640 28S ribosomal protein S34, mitochondrial
  • InterPro Domains
    IPR032053 Mitochondrial 28S ribosomal protein S34
Molecular
Reagents
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  • All nucleic 9
    cDNA 9

    Microarray probesets 2
Other
Accession IDs
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MGI:1914087, MGI:1924352, MGI:2147008
References
more
  • Summaries
    All 29
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:63450 Kargul GJ, et al., Eleven densely clustered genes, six of them novel, in 176 kb of mouse t-complex DNA. Genome Res. 2000 Jul;10(7):916-23
  • Latest
    J:222643 Richman TR, et al., Mutation in MRPS34 compromises protein synthesis and causes mitochondrial dysfunction. PLoS Genet. 2015 Mar;11(3):e1005089

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory