Pmaip1
Gene Detail

Symbol Name ID

Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 MGI:1930146

Synonyms

Noxa

Feature Type

protein coding gene

Genetic Map

Chromosome 18

39.52 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr18:66458604-66465550 bp, + strand From Ensembl annotation of GRCm38   6947 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:75166  Vertebrate Homology Class
1 mouse; 1 rat

Gene Tree: Pmaip1

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Though inactivation of this gene results in apoptotic abnormalities, homozygous null mice develop normally and show no evidence of tumorigenesis.

 

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	activation of cysteine-type endopeptidase activity involved in apoptotic process, apoptotic process, ...
Component	mitochondrion
Function	protein binding

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (16 records)
Data Summary: Results (44)    Tissues (29)    Images (5)
Theiler Stages: 20, 21, 28

Assay Type	Results
RNA in situ	35
RT-PCR	9

cDNA source data(28)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(32) cDNA(28) Primer pair(3) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000024521 (Evidence)
Entrez Gene	58801 (Evidence)
UniGene	271878
DFCI	TC1580828, TC1597591
DoTS	DT.528652
NIA Mouse Gene Index	U018834
PDB	2NLA, 2ROD, 2JM6
Consensus CDS Project	CCDS29315.1
International Mouse Knockout Project Status	Pmaip1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000024521	Ensembl Gene Model | MGI Sequence Detail	6947	C57BL/6J
transcript	ENSMUST00000025399	Ensembl | MGI Sequence Detail	2646	Not Applicable
polypeptide	ENSMUSP00000025399	Ensembl | MGI Sequence Detail	103	Not Applicable

All sequences(19) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(36 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR024140	Phorbol-12-myristate-13-acetate-induced protein 1/Noxa
Protein Ontology	PR:000012900	phorbol-12-myristate-13-acetate-induced protein 1

References

(Earliest) J:62057 Oda E, et al., Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science. 2000 May 12;288(5468):1053-8
(Latest) J:193027 Wensveen FM, et al., Pro-apoptotic protein Noxa regulates memory T cell population size and protects against lethal immunopathology. J Immunol. 2013 Feb 1;190(3):1180-91
All references(80)