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Ern1 Gene Detail
Summary
  • Symbol
    Ern1
  • Name
    endoplasmic reticulum (ER) to nucleus signalling 1
  • Synonyms
    9030414B18Rik, Ire1a, Ire1alpha, Ire1p
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930134
    NCBI Gene: 78943
  • Gene Overview
    MyGene.info: ERN1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:106397620-106487796 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 69.14 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    492 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1930134
protein coding gene Chr11:106394650-106487852 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019308
protein coding gene Chr11:109685701-109787385 (-)
A/J MGP_AJ_G0019276
protein coding gene Chr11:105018457-105114379 (-)
AKR/J MGP_AKRJ_G0019245
protein coding gene Chr11:108150065-108245348 (-)
BALB/cJ MGP_BALBcJ_G0019250
protein coding gene Chr11:105428029-105523464 (-)
C3H/HeJ MGP_C3HHeJ_G0019059
protein coding gene Chr11:108439479-108539473 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019700
protein coding gene Chr11:113041732-113159799 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017324
protein coding gene Chr11:102295791-102389777 (-)
CAST/EiJ MGP_CASTEiJ_G0018612
protein coding gene Chr11:109503825-109614140 (-)
CBA/J MGP_CBAJ_G0019028
protein coding gene Chr11:117750347-117860616 (-)
DBA/2J MGP_DBA2J_G0019140
protein coding gene Chr11:104487878-104584145 (-)
FVB/NJ MGP_FVBNJ_G0019131
protein coding gene Chr11:103994154-104087670 (-)
LP/J MGP_LPJ_G0019210
protein coding gene Chr11:110129826-110226809 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019161
protein coding gene Chr11:117019442-117126310 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019737
protein coding gene Chr11:108639867-108736965 (-)
PWK/PhJ MGP_PWKPhJ_G0018377
protein coding gene Chr11:105585244-105679790 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018168
protein coding gene Chr11:108417445-108516972 (-)
WSB/EiJ MGP_WSBEiJ_G0018663
protein coding gene Chr11:108607823-108718203 (-)



Homology
more
  • Human Ortholog
    ERN1, endoplasmic reticulum to nucleus signaling 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ERN1, endoplasmic reticulum to nucleus signaling 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    hIRE1p, IRE1, IRE1a, IRE1P
  • Links
    NCBI Gene ID: 2081
    neXtProt AC: NX_O75460
    UniProt: O75460

  • Chr Location
    17q23.3; chr17:64039142-64130819 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 55580
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ERN1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 6 alleles in 7 genetic backgrounds
    1 phenotype from multigenic genotypes
    53 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for null mutations display embryonic lethality during organogenesis. Homozygous mice may also display decreased embryo size, impaired hematopoiesis, and/or placental abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 78943 NCBI Gene Model | MGI Sequence Detail 90177 C57BL/6J ±  kb
    transcript NM_023913 RefSeq | MGI Sequence Detail 3976 Not Specified  
    polypeptide Q9EQY0 UniProt | EBI | MGI Sequence Detail 977 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 67
      cDNA 66
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1918791, MGI:2144086, MGI:2144679
    References
    more
    • Summaries
      All 148
      Developmental Gene Expression 9
      Gene Ontology 19
      Phenotypes 53
    • Earliest
      J:57921 Wang XZ, et al., Cloning of mammalian Ire1 reveals diversity in the ER stress responses. EMBO J. 1998 Oct 1;17(19):5708-17
    • Latest
      J:265034 Bartelt A, et al., Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity. Nat Med. 2018 Mar;24(3):292-303

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory