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Pdcd1lg2
Gene Detail
Symbol

Name
ID
Pdcd1lg2
programmed cell death 1 ligand 2
MGI:1930125
Synonyms
B7-DC, Btdc, F730015O22Rik, PD-L2
Feature Type
protein coding gene
Genetic Map
Chromosome 19
23.93 cM, cytoband C2-C3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:29410919-29471157 bp, + strand
From VEGA annotation of GRCm38

  60239 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10973  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: PDCD1LG2
Protein SuperFamily: programmed cell death 1 ligand
Gene Tree: Pdcd1lg2

Human
homologs
PDCD1LG2, programmed cell death 1 ligand 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 80380
neXtProt AC: NX_Q9BQ51

Human Synonyms: B7DC, bA574F11.2, Btdc, CD273, PDCD1L2, PDL2, PD-L2

Human Chr (Location): 9p24.2; chr9:5510491-5571282 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Targeted(11)
Incidental mutations (data from APF )
 
Mice homozygous for disruptions in this gene have dendritic cells that display a diminished ability to activate CD4+ T cells.
 
Interactions
Pdcd1lg2 interacts with 132 markers (Mir7-1, Mir10a, Mir10b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (65)    Tissues (44)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 57
Western blot 4
RT-PCR 4
cDNA source data(7)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) cDNA(7) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000014902 (Evidence)
Ensembl Gene Model ENSMUSG00000016498 (Evidence)
Entrez Gene 58205 (Evidence)
UniGene 116737
DFCI TC1611161, TC1587364, TC1592254
DoTS DT.91593796, DT.91333536, DT.91333535, DT.101364013
NIA Mouse Gene Index U019349, U019350
PDB 3RNK, 3RNQ, 3BOV, 3BP5, 3BP6
Consensus CDS Project CCDS29736.1
International Mouse Phenotyping Consortium Status Pdcd1lg2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014902 VEGA Gene Model | MGI Sequence Detail 60239 C57BL/6J ±  kb
transcript OTTMUST00000035401 VEGA | MGI Sequence Detail 1645 Not Applicable 
polypeptide OTTMUSP00000015822 VEGA | MGI Sequence Detail 247 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(174 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
Protein Ontology PR:000001544 programmed cell death 1 ligand 2
References
(Earliest) J:67842 Latchman Y, et al., PD-L2 is a second ligand for PD-I and inhibits T cell activation. Nat Immunol. 2001 Mar;2(3):261-8
(Latest) J:211305 Xiao Y, et al., RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance. J Exp Med. 2014 May 5;211(5):943-59
All references(66)
Other
accession IDs
MGI:2442044

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory