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Pdcd1lg2
Gene Detail
 Symbol
Name
ID
Pdcd1lg2
programmed cell death 1 ligand 2
MGI:1930125
Synonyms B7-DC, Btdc, F730015O22Rik, PD-L2
Feature Type protein coding gene
Genetic Map
Chromosome 19
23.93 cM, cytoband C2-C3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:29410919-29471157 bp, + strand
From VEGA annotation of GRCm38

  60239 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10973  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: programmed cell death 1 ligand
Gene Tree: Pdcd1lg2

Human
homologs
Human Homolog PDCD1LG2, programmed cell death 1 ligand 2
NCBI Gene ID 80380
neXtProt AC  NX_Q9BQ51
Human Synonyms  B7DC, bA574F11.2, Btdc, CD273, PDCD1L2, PDL2, PD-L2
Human Chr (Location)  9p24.2; chr9:5510512-5571282 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Targeted(11)
Incidental mutations (data from APF )
 
Mice homozygous for disruptions in this gene have dendritic cells that display a diminished ability to activate CD4+ T cells.
 
Interactions
Pdcd1lg2 interacts with 132 markers (Mir7-1, Mir10a, Mir10b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process negative regulation of T cell proliferation, positive regulation of T cell proliferation
Component extracellular vesicular exosome, integral component of membrane, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (65)    Tissues (44)   
Theiler Stages: 17, 20, 22, 26, 28
Assay TypeResults
Immunohistochemistry 57
Western blot 4
RT-PCR 4
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) cDNA(7) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000014902 (Evidence)
Ensembl Gene ModelENSMUSG00000016498 (Evidence)
Entrez Gene58205 (Evidence)
UniGene116737
DFCITC1587364, TC1592254, TC1611161
DoTSDT.101364013, DT.91333535, DT.91333536, DT.91593796
NIA Mouse Gene IndexU019349, U019350
PDB3BOV, 3RNK, 3RNQ, 3BP5, 3BP6
Consensus CDS ProjectCCDS29736.1
International Mouse Knockout Project StatusPdcd1lg2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014902 VEGA Gene Model | MGI Sequence Detail 60239 C57BL/6J ±  kb
transcript OTTMUST00000035401 VEGA | MGI Sequence Detail 1645 Not Applicable 
polypeptide OTTMUSP00000015822 VEGA | MGI Sequence Detail 247 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(174 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
Protein Ontology PR:000001544 programmed cell death 1 ligand 2
References (Earliest) J:67842 Latchman Y, et al., PD-L2 is a second ligand for PD-I and inhibits T cell activation. Nat Immunol. 2001 Mar;2(3):261-8
(Latest) J:208202 Gao Y, et al., Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells. Immunity. 2013 Oct 17;39(4):722-32
All references(66)
Other
accession IDs
MGI:2442044

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory