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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pdcd1lg2
programmed cell death 1 ligand 2
MGI:1930125
21 phenotypes from 5 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Pdcd1lg2tm1.1Lex/Pdcd1lg2tm1.1Lex
involves: 129S5/SvEvBrd 		decreased CD8-positive, alpha-beta T cell number J:126829
Pdcd1lg2tm1Dmp/Pdcd1lg2tm1Dmp
C.129-Pdcd1lg2tm1Dmp 		abnormal cytokine secretion J:99212
abnormal cytotoxic T cell physiology J:99212
decreased IgG2a level J:99212
decreased T cell proliferation J:99212
increased susceptibility to induced morbidity/mortality J:99212
increased tumor growth/size J:99212
Pdcd1lg2tm1Dmp/Pdcd1lg2tm1Dmp
involves: 129X1/SvJ * 129S1/Sv * C57BL/6 		abnormal dendritic cell antigen presentation J:84457
Pdcd1lg2tm1Shr/Pdcd1lg2tm1Shr
involves: 129/Sv * 129S4/SvJae 		increased IgG2a level J:113851
increased IgM level J:113851
increased susceptibility to parasitic infection J:113851
Pdcd1lg2tm2Shr/Pdcd1lg2tm2Shr
C.B6-Pdcd1lg2tm2Shr 		abnormal dendritic cell physiology J:123785
increased interferon-gamma secretion J:123785
increased interleukin-2 secretion J:123785
Pdcd1lg2tm3Shr/Pdcd1lg2tm3Shr
involves: C57BL/6 * NOD/MrkTac 		abnormal CD8-positive, alpha-beta T cell physiology J:123785
hyperglycemia J:123785
increased CD4-positive, alpha-beta T cell number J:123785
increased CD8-positive, alpha-beta T cell number J:123785
increased susceptibility to autoimmune diabetes J:123785
insulitis J:123785
lymph node hyperplasia J:123785
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory