Pdcd1lg2^tm1Dmp
Targeted Allele Detail

Summary

• Symbol: Pdcd1lg2^tm1Dmp
• Name: programmed cell death 1 ligand 2; targeted mutation 1, Drew M Pardoll
• MGI ID: MGI:3582552
• Synonyms: B7-DC
• Gene: Pdcd1lg2 Location: Chr19:29388319-29448561 bp, + strand Genetic Position: Chr19, 23.93 cM, cytoband C2-C3
• Alliance: Pdcd1lg2^tm1Dmp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99212
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The signal peptide containing the ATG initiation codon was replaced with EGFP and a NEO cassette (Pdcd1lg2^tm2Dmp.). The neomycin cassette was subsequently excised by crossing to a cre expressing transgenic mouse. Expression was completely abolished. (J:99212)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdcd1lg2 Mutation: 23 strains or lines available

References

• Original: J:99212 Shin T, et al., In vivo costimulatory role of B7-DC in tuning T helper cell 1 and cytotoxic T lymphocyte responses. J Exp Med. 2005 May 16;201(10):1531-41
• All: 13 reference(s)