Pdcd1lg2^tm3Shr
Targeted Allele Detail

Summary

• Symbol: Pdcd1lg2^tm3Shr
• Name: programmed cell death 1 ligand 2; targeted mutation 3, Arlene H Sharpe
• MGI ID: MGI:3720328
• Synonyms: PD-L1/L2^-, PD-L1/PD-L2^-
• Gene: Pdcd1lg2 Location: Chr19:29388319-29448561 bp, + strand Genetic Position: Chr19, 23.93 cM, cytoband C2-C3
• Alliance: Pdcd1lg2^tm3Shr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123785
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace the IgV exon with a hygromycin resistance gene in ES cells containing the Cd274^tm1Shr allele in which the CD274 antigen signal and all of the IgV exon were replaced with a neomycin resistance gene. (J:123785)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdcd1lg2 Mutation: 23 strains or lines available

References

• Original: J:123785 Keir ME, et al., Tissue expression of PD-L1 mediates peripheral T cell tolerance. J Exp Med. 2006 Apr 17;203(4):883-95
• All: 11 reference(s)