Bhlhe22
Gene Detail

Symbol Name ID

Bhlhe22 basic helix-loop-helix family, member e22 MGI:1930001

Synonyms

Beta3, Bhlhb5

Feature Type

protein coding gene

Genetic Map

Chromosome 3

4.98 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr3:18054174-18057517 bp, + strand From VEGA annotation of GRCm38   3344 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:10994  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 zebrafish

Gene Tree: Bhlhe22

Human homologs

Human Homolog		BHLHE22, basic helix-loop-helix family, member e22
NCBI Gene ID		27319
neXtProt AC		NX_Q8NFJ8
Human Synonyms		Beta3, BHLHB5, CAGL85, TNRC20
Human Chr (Location)		8q13; chr8:65492795-65496191 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for a null mutation are slow to gain weight, develop skin lesions, have reduced numbers of specific subtypes of amacrine and cone bipolar cells, and exhibit abnormal innervation of the corticospinal tract.

 

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	anterior commissure morphogenesis, central nervous system projection neuron axonogenesis, ...
Component	nucleus
Function	chromatin binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (41 records)
Data Summary: Results (234)    Tissues (191)    Images (65)
Theiler Stages: 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 28

Assay Type	Results
RNA in situ	234

cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(14) Genomic(2) cDNA(11) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000018225 (Evidence)
Ensembl Gene Model	ENSMUSG00000025128 (Evidence)
Entrez Gene	59058 (Evidence)
UniGene	149938
DFCI	TC1581998
DoTS	DT.55280995
NIA Mouse Gene Index	U003055
Consensus CDS Project	CCDS17253.1
International Mouse Knockout Project Status	Bhlhe22

Sequences

Length	Strain/Species
genomic	OTTMUSG00000018225	VEGA Gene Model | MGI Sequence Detail	3344	C57BL/6J
transcript	OTTMUST00000044037	VEGA | MGI Sequence Detail	3344	Not Applicable
polypeptide	OTTMUSP00000019781	VEGA | MGI Sequence Detail	355	Not Applicable

All sequences(19) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(1 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology	PR:000004738	class E basic helix-loop-helix protein 22

References

(Earliest) J:76824 Kim M, et al., Region-specific expression of the helix-loop-helix gene BETA3 in developing and adult brains. Mech Dev. 2002 Jun;114(1-2):125
(Latest) J:192361 Srinivasan K, et al., A network of genetic repression and derepression specifies projection fates in the developing neocortex. Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19071-8
All references(65)