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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Bhlhe22
basic helix-loop-helix family, member e22
MGI:1930001
27 phenotypes from 3 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Bhlhe22tm1Gan/\Bhlhe22tm1Gan
involves: 129S7/SvEvBrd 		abnormal anterior corticospinal tract morphology J:144066
abnormal cerebral cortex morphology J:144066
abnormal corticospinal tract morphology J:144066
abnormal motor neuron morphology J:144066
abnormal nervous system tract morphology J:144066
abnormal pyramidal decussation morphology J:144066
abnormal somatosensory cortex morphology J:144066
decreased body weight J:144066
decreased brain size J:144066
disorganized barrel cortex J:144066
\Bhlhe22tm1Gan/\Bhlhe22tm1Gan
involves: 129S7/SvEvBrd * C57BL/6 		abnormal retina cone bipolar cell morphology J:119663
decreased amacrine cell number J:119663
decreased body weight J:119663
skin lesions J:119663
thin retina inner nuclear layer J:119663
\Bhlhe22tm1Meg/\Bhlhe22tm1Meg
either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * CD-1) 		abnormal behavior J:158273
abnormal chemical nociception J:158273
abnormal nervous system physiology J:158273
abnormal sensory capabilities/reflexes/nociception J:158273
excessive scratching J:158273
skin lesions J:158273
\Bhlhe22tm1Meg/\Bhlhe22tm1Meg
involves: 129S6/SvEvTac * C57BL/6J 		abnormal anterior corticospinal tract morphology J:182304
abnormal axon guidance J:182304
abnormal motor coordination/balance J:182304
absent anterior commissure J:182304
absent corpus callosum J:182304
absent hippocampal commissure J:182304
excessive scratching J:182304
normal nervous system phenotype J:182304
skin lesions J:182304
\Bhlhe22tm2.1Meg/\Bhlhe22tm2.1Meg
\Emx1tm1(cre)Krj/\Emx1+
involves: 129/Sv * 129S2/SvPas 		normal behavior/neurological phenotype J:158273
normal integument phenotype J:158273
\Bhlhe22tm2.1Meg/\Bhlhe22tm2.1Meg
\Emx1tm1(cre)Krj/\Emx1+
involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J 		abnormal anterior corticospinal tract morphology J:182304
absent corpus callosum J:182304
absent hippocampal commissure J:182304
\Bhlhe22tm2.1Meg/\Bhlhe22tm2.1Meg
\H2az2Tg(Wnt1-cre)11Rth/\H2az2+
involves: 129/Sv * C57BL/6J * CBA/J 		abnormal chemical nociception J:158273
excessive scratching J:158273
skin lesions J:158273
\Bhlhe22tm2.1Meg/\Bhlhe22tm2.1Meg
\Tg(Nes-cre)1Kln/0
involves: 129/Sv * C57BL/6 * SJL 		excessive scratching J:158273
skin lesions J:158273
\Bhlhe22tm2.1Meg/\Bhlhe22tm2.1Meg
\Tg(Pax2-cre)1Akg/0
involves: 129 		abnormal chemical nociception J:158273
excessive scratching J:158273
skin lesions J:158273
\Bhlhe22tm2.1Meg/\Bhlhe22tm2.1Meg
\Tg(PLAT-cre)116Sdu/0
involves: 129 		normal behavior/neurological phenotype J:158273
normal integument phenotype J:158273
\Bhlhe22tm2.1Meg/\Bhlhe22tm2.1Meg
\Tlx3tm1(cre)Qima/\Tlx3+
involves: 129 		normal behavior/neurological phenotype J:158273
normal integument phenotype J:158273
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory