About   Help   FAQ
Klf15 Gene Detail
Summary
  • Symbol
    Klf15
  • Name
    Kruppel-like factor 15
  • Synonyms
    1810013I09Rik, CKLF, KKLF
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929988
    NCBI Gene: 66277
  • Gene Overview
    MyGene.info: KLF15
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr6:90462576-90475238 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12663 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 40.16 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    KLF15, Kruppel like factor 15
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KLF15, Kruppel like factor 15
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KKLF
  • Links
    NCBI Gene ID: 28999
    neXtProt AC: NX_Q9UIH9
    UniProt: Q9UIH9

  • Chr Location
    3q21.3; chr3:126288121-126357393 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8553
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: KLF15
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Klf15 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    40 phenotypes from 2 alleles in 3 genetic backgrounds
    9 phenotypes from multigenic genotypes
    1 images
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display impaired gluconeogenesis with severe fasting induce hypoglycemia. Homozygotes are also more sensitive to induced cardiac stress and display mild cardiac and aortic abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000022237 VEGA Gene Model | MGI Sequence Detail 12663 C57BL/6J ±  kb
    transcript OTTMUST00000052904 VEGA | MGI Sequence Detail 2373 Not Applicable  
    polypeptide OTTMUSP00000025136 VEGA | MGI Sequence Detail 415 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      25 from dbSNP Build 142
    • PCR
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 51
      cDNA 48
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1913527, MGI:2141613, MGI:2141686
    References
    more
    • Summaries
      All 75
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 10
      Phenotypes 29
    • Earliest
      J:21726 Champion KM, et al., Identification of a heritable deficiency of the folate-dependent enzyme 10-formyltetrahydrofolate dehydrogenase in mice. Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11338-42
    • Latest
      J:257458 Sugi K, et al., Kruppel-like factor 15 is required for the cardiac adaptive response to fasting. PLoS One. 2018;13(2):e0192376

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory