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Klf15
Gene Detail
Symbol

Name
ID
Klf15
Kruppel-like factor 15
MGI:1929988
Synonyms
1810013I09Rik, CKLF, KKLF
Feature Type
protein coding gene
Genetic Map
Chromosome 6
40.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:90462576-90475238 bp, + strand
From VEGA annotation of GRCm38

  12663 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8553  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: KLF15
Gene Tree: Klf15

Human
homologs
KLF15, Kruppel-like factor 15
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 28999
neXtProt AC: NX_Q9UIH9

Human Synonyms: KKLF

Human Chr (Location): 3q21.3; chr3:126342635-126357393 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(2) Radiation induced(1) Spontaneous(1) Targeted(3)
Genomic Mutations involving Klf15 (2)
 
Mice homozygous for a null allele display impaired gluconeogenesis with severe fasting induce hypoglycemia. Homozygotes are also more sensitive to induced cardiac stress and display mild cardiac and aortic abnormalities.
 
Interactions
Klf15 interacts with 201 markers (Mir1b, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process cardiac muscle hypertrophy in response to stress, glial cell differentiation, ...
Component nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (221)    Tissues (97)    Images (27)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 209
In situ reporter (knock in) 3
RT-PCR 9
cDNA source data(47)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA KLF15 ; Xenbase klf15, LOC100494101 ; ZFIN klf15    NEW 
Molecular
reagents
All nucleic(51) cDNA(48) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000022237 (Evidence)
Ensembl Gene Model ENSMUSG00000030087 (Evidence)
Entrez Gene 66277 (Evidence)
UniGene 41389
DFCI TC1576597
DoTS DT.489628, DT.94348698
NIA Mouse Gene Index U007173
Consensus CDS Project CCDS20360.1
International Mouse Phenotyping Consortium Status Klf15
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022237 VEGA Gene Model | MGI Sequence Detail 12663 C57BL/6J ±  kb
transcript OTTMUST00000052904 VEGA | MGI Sequence Detail 2373 Not Applicable 
polypeptide OTTMUSP00000025136 VEGA | MGI Sequence Detail 415 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(9) UniProt(1)
Polymorphisms
PCR(1) : SNPs within 2kb(14 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000009359 krueppel-like factor 15
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:208341 Seth A, et al., Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment. Development. 2014 Feb;141(3):538-47
All references(63)
Other
accession IDs
MGI:1913527, MGI:2141613, MGI:2141686

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory