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Klf15 Gene Detail
Summary
  • Symbol
    Klf15
  • Name
    Kruppel-like factor 15
  • Synonyms
    1810013I09Rik, CKLF, KKLF
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929988
    NCBI Gene: 66277
  • Gene Overview
    MyGene.info: KLF15
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:90462576-90475238 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 40.16 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    25 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929988
protein coding gene Chr6:90462545-90479170 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031038
protein coding gene Chr6:91994935-92007597 (+)
A/J MGP_AJ_G0031006
protein coding gene Chr6:88494568-88507229 (+)
AKR/J MGP_AKRJ_G0030938
protein coding gene Chr6:90972820-90985482 (+)
BALB/cJ MGP_BALBcJ_G0031018
protein coding gene Chr6:88440781-88453443 (+)
C3H/HeJ MGP_C3HHeJ_G0030690
protein coding gene Chr6:93463546-93476203 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031477
protein coding gene Chr6:94420069-94432732 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028646
protein coding gene Chr6:86486042-86498771 (+)
CAST/EiJ MGP_CASTEiJ_G0030125
protein coding gene Chr6:91077907-91090572 (+)
CBA/J MGP_CBAJ_G0030704
protein coding gene Chr6:97948028-97960695 (+)
DBA/2J MGP_DBA2J_G0030857
protein coding gene Chr6:87688065-87700719 (+)
FVB/NJ MGP_FVBNJ_G0030811
protein coding gene Chr6:86889187-86901851 (+)
LP/J MGP_LPJ_G0030937
protein coding gene Chr6:91971269-91983933 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030845
protein coding gene Chr6:102032336-102045002 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031504
protein coding gene Chr6:90807278-90819937 (+)
PWK/PhJ MGP_PWKPhJ_G0029841
protein coding gene Chr6:86632779-86645404 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029670
protein coding gene Chr6:89702911-89715580 (+)
WSB/EiJ MGP_WSBEiJ_G0030209
protein coding gene Chr6:91274088-91286756 (+)



Homology
more
  • Human Ortholog
    KLF15, Kruppel like factor 15
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KLF15, Kruppel like factor 15
    Orthology source: HGNC, HomoloGene
  • Synonyms
    KKLF
  • Links
    NCBI Gene ID: 28999
    neXtProt AC: NX_Q9UIH9
    UniProt: Q9UIH9

  • Chr Location
    3q21.3; chr3:126288121-126357393 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8553
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: KLF15
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Klf15 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    40 phenotypes from 2 alleles in 3 genetic backgrounds
    9 phenotypes from multigenic genotypes
    1 images
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display impaired gluconeogenesis with severe fasting induce hypoglycemia. Homozygotes are also more sensitive to induced cardiac stress and display mild cardiac and aortic abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030087 Ensembl Gene Model | MGI Sequence Detail 12663 C57BL/6J ±  kb
    transcript ENSMUST00000203607 Ensembl | MGI Sequence Detail 2240 Not Applicable  
    polypeptide ENSMUSP00000144808 Ensembl | MGI Sequence Detail 415 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 52
      cDNA 49
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1913527, MGI:2141613, MGI:2141686
    References
    more
    • Summaries
      All 79
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 12
      Phenotypes 33
    • Earliest
      J:21726 Champion KM, et al., Identification of a heritable deficiency of the folate-dependent enzyme 10-formyltetrahydrofolate dehydrogenase in mice. Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11338-42
    • Latest
      J:257458 Sugi K, et al., Kruppel-like factor 15 is required for the cardiac adaptive response to fasting. PLoS One. 2018;13(2):e0192376

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory