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Akr1a1 Gene Detail
Summary
  • Symbol
    Akr1a1
  • Name
    aldo-keto reductase family 1, member A1 (aldehyde reductase)
  • Synonyms
    2610201A18Rik, Akr1a4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929955
    NCBI Gene: 58810
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr4:116636510-116651680 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15171 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 53.26 cM, cytoband C7
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    AKR1A1, aldo-keto reductase family 1 member A1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AKR1A1, aldo-keto reductase family 1 member A1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ALDR1, ALR, ARM, DD3, HEL-S-6
  • Links
    NCBI Gene ID: 10327
    neXtProt AC: NX_P14550
    UniProt: P14550

  • Chr Location
    1p34.1; chr1:45550779-45570051 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 74565
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: AKR1A1
  • Protein SuperFamily
    AKR
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    5 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit increased osteoporosis in response to pregnancy or castration in the absence of dietary ascorbate. Mice homozygous for a knock-out allele exhibit reduced asorbic acid levels and DL-glyceraldehyde, glucuronolactone and glucuronate reductase activity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000009532 VEGA Gene Model | MGI Sequence Detail 15171 C57BL/6J ±  kb
    transcript OTTMUST00000021818 VEGA | MGI Sequence Detail 1420 Not Applicable  
    polypeptide OTTMUSP00000009953 VEGA | MGI Sequence Detail 325 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      39 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      cDNA 34
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1914397
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 3
      Gene Ontology 9
      Phenotypes 17
    • Earliest
      J:63126 Allan D, et al., Cloning and developmental expression of mouse aldehyde reductase (AKR1A4). Mech Dev. 2000 Jun;94(1-2):271-5
    • Latest
      J:238959 Akihara R, et al., Ablation of aldehyde reductase aggravates carbon tetrachloride-induced acute hepatic injury involving oxidative stress and endoplasmic reticulum stress. Biochem Biophys Res Commun. 2016 Sep 16;478(2):765-71

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/16/2018
    MGI 6.12
    The Jackson Laboratory