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Akr1a1
Gene Detail
Symbol

Name
ID
Akr1a1
aldo-keto reductase family 1, member A1 (aldehyde reductase)
MGI:1929955
Synonyms
2610201A18Rik, Akr1a4
Feature Type
protein coding gene
Genetic Map
Chromosome 4
53.26 cM, cytoband C7
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:116636510-116651680 bp, - strand
From VEGA annotation of GRCm38

  15171 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74565  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: AKR
Gene Tree: Akr1a1

Human
homologs
Human Homolog AKR1A1, aldo-keto reductase family 1, member A1 (aldehyde reductase)
NCBI Gene ID 10327
neXtProt AC  NX_P14550
Human Synonyms  ALDR1, ALR, ARM, DD3, HEL-S-6
Human Chr (Location)  1p33-p32; chr1:45550783-45570051 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(97) : Gene trapped(93) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trap allele exhibit increased osteoporosis in response to pregnancy or castration in the absence of dietary ascorbate. Mice homozygous for a knock-out allele exhibit reduced asorbic acid levels and DL-glyceraldehyde, glucuronolactone and glucuronate reductase activity.
 
Phenotype Images(5)
Interactions
Akr1a1 interacts with 20 markers (Mir22, Mir135a-1, Mir135a-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (185)    Tissues (148)    Images (47)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 175
Northern blot 10
cDNA source data(33)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(34) cDNA(33) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000009532 (Evidence)
Ensembl Gene ModelENSMUSG00000028692 (Evidence)
Entrez Gene58810 (Evidence)
DFCITC1696427, TC1573724, TC1735353
DoTSDT.101402586, DT.101402730, DT.101719922, DT.110808128, DT.110808016, DT.97367035, DT.97356060, DT.537670
NIA Mouse Gene IndexU025416
EC1.1.1.2
PDB4GAC
Consensus CDS ProjectCCDS18514.1
International Mouse Knockout Project StatusAkr1a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009532 VEGA Gene Model | MGI Sequence Detail 15171 C57BL/6J ±  kb
transcript OTTMUST00000021818 VEGA | MGI Sequence Detail 1420 Not Applicable 
polypeptide OTTMUSP00000009953 VEGA | MGI Sequence Detail 325 Not Applicable 

For the selected sequences
All sequences(91) RefSeq(4) UniProt(9)
Polymorphisms
SNPs within 2kb(39 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001395 Aldo/keto reductase
InterPro IPR018170 Aldo/keto reductase, conserved site
InterPro IPR020471 Aldo/keto reductase subgroup
InterPro IPR023210 NADP-dependent oxidoreductase domain
Protein Ontology PR:000003900 alcohol dehydrogenase [NADP(+)]
References
(Earliest) J:63126 Allan D, et al., Cloning and developmental expression of mouse aldehyde reductase (AKR1A4). Mech Dev. 2000 Jun;94(1-2):271-5
(Latest) J:188043 Takahashi M, et al., In vivo role of aldehyde reductase. Biochim Biophys Acta. 2012 Nov;1820(11):1787-96
All references(39)
Other
accession IDs
MGI:1914397

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory