Akr1a1
Gene Detail

Symbol Name ID

Akr1a1 aldo-keto reductase family 1, member A1 (aldehyde reductase) MGI:1929955

Synonyms

2610201A18Rik, Akr1a4

Feature Type

protein coding gene

Genetic Map

Chromosome 4

53.26 cM, cytoband C7
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr4:116636510-116651680 bp, - strand From VEGA annotation of GRCm38   15171 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:74565  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: AKR
Gene Tree: Akr1a1

Human homologs

Human Homolog		AKR1A1, aldo-keto reductase family 1, member A1 (aldehyde reductase)
NCBI Gene ID		10327
neXtProt AC		NX_P14550
Human Synonyms		ALDR1, ALR, ARM, DD3
Human Chr (Location)		1p33-p32; chr1:46016455-46035723 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(97) : Targeted(4) Gene trapped(93)
 

Mice homozygous for a gene trap allele exhibit increased osteoporosis in response to pregnancy or castration in the absence of dietary ascorbate. Mice homozygous for a knock-out allele exhibit reduced asorbic acid levels and DL-glyceraldehyde, glucuronolactone and glucuronate reductase activity.

 
Phenotype Images(5)

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	aldehyde catabolic process, D-glucuronate catabolic process, ...
Component	apical plasma membrane, cytosol
Function	alcohol dehydrogenase (NADP+) activity, alditol:NADP+ 1-oxidoreductase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (185)    Tissues (148)    Images (47)
Theiler Stages: 11, 13, 14, 15, 17, 19, 20, 21, 22, 28

Assay Type	Results
RNA in situ	175
Northern blot	10

cDNA source data(861)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(862) cDNA(861) Primer pair(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000009532 (Evidence)
Ensembl Gene Model	ENSMUSG00000028692 (Evidence)
Entrez Gene	58810 (Evidence)
UniGene	30085
DFCI	TC1573724, TC1696427, TC1735353
DoTS	DT.101402586, DT.101402730, DT.101719922, DT.110808016, DT.110808128, DT.537670, DT.97356060, DT.97367035
NIA Mouse Gene Index	U025416
EC	1.1.1.2
PDB	4GAC
Consensus CDS Project	CCDS18514.1
International Mouse Knockout Project Status	Akr1a1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000009532	VEGA Gene Model | MGI Sequence Detail	15171	C57BL/6J
transcript	OTTMUST00000021818	VEGA | MGI Sequence Detail	1420	Not Applicable
polypeptide	OTTMUSP00000009953	VEGA | MGI Sequence Detail	325	Not Applicable

All sequences(85) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(9 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001395	Aldo/keto reductase
InterPro	IPR018170	Aldo/keto reductase, conserved site
InterPro	IPR020471	Aldo/keto reductase subgroup
InterPro	IPR023210	NADP-dependent oxidoreductase domain
Protein Ontology	PR:000003900	alcohol dehydrogenase [NADP+]

References

(Earliest) J:63126 Allan D, et al., Cloning and developmental expression of mouse aldehyde reductase (AKR1A4). Mech Dev. 2000 Jun;94(1-2):271-5
(Latest) J:188043 Takahashi M, et al., In vivo role of aldehyde reductase. Biochim Biophys Acta. 2012 Nov;1820(11):1787-96
All references(39)

Other accession IDs

MGI:1914397