Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in cellular detoxification of aldehyde and glucuronate catabolic process to xylulose 5-phosphate. Acts upstream of or within D-glucuronate catabolic process; L-ascorbic acid biosynthetic process; and aldehyde catabolic process. Located in apical plasma membrane. Is active in cytosol and synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Orthologous to human AKR1A1 (aldo-keto reductase family 1 member A1).