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Perp Gene Detail
Summary
  • Symbol
    Perp
  • Name
    PERP, TP53 apoptosis effector
  • Synonyms
    1110017A08Rik, KCP1, KRTCAP1, PIGPC1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929938
    NCBI Gene: 64058
  • Gene Overview
    MyGene.info: PERP
Location & Maps
more
  • Sequence Map
    Chr10:18845071-18857073 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12003 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 7.97 cM, cytoband A2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PERP, PERP, TP53 apoptosis effector
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PERP, PERP, TP53 apoptosis effector
    Orthology source: HGNC, HomoloGene
  • Synonyms
    dJ496H19.1, KCP1, KRTCAP1, PIGPC1, THW
  • Links
    NCBI Gene ID: 64065
    neXtProt AC: NX_Q96FX8

  • Chr Location
    6q24; chr6:138088505-138107523 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 11098
    1 human;1 mouse;1 rat;1 rhesus macaque;1 cattle;1 dog;2 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: PERP
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Targeted
    4
  • Genomic Mutations
    1 involving Perp
  • Incidental Mutations
Homozygous inactivation of this locus results in increased lethality during the postnatal period.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 64058 NCBI Gene Model | MGI Sequence Detail 12003 C57BL/6J ±  kb
transcript NM_022032 RefSeq | MGI Sequence Detail 1901 C57BL/6  
polypeptide Q9JK95 UniProt | EBI | MGI Sequence Detail 193 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    148 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000012551 p53 apoptosis effector related to PMP-22
  • InterPro Domains
    IPR015664 P53-induced protein
    IPR004031 PMP-22/EMP/MP20/Claudin superfamily
Molecular
Reagents
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  • All nucleic 9
    cDNA 9

    Microarray probesets 3
Other
Accession IDs
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MGI:1915072
References
more
  • Summaries
    All 45
    Developmental Gene Expression 11
    Gene Ontology 8
    Phenotypes 16
  • Earliest
    J:67123 Attardi LD, et al., PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family. Genes Dev. 2000 Mar 15;14(6):704-18
  • Latest
    J:229930 Nechiporuk T, et al., The REST remodeling complex protects genomic integrity during embryonic neurogenesis. Elife. 2016;5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory