Perp
Gene Detail

Symbol Name ID

Perp PERP, TP53 apoptosis effector MGI:1929938

Synonyms

1110017A08Rik, KCP1, KRTCAP1, PIGPC1

Feature Type

protein coding gene

Genetic Map

Chromosome 10

7.97 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr10:18845071-18857073 bp, + strand From NCBI annotation of GRCm38   12003 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:11098  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 zebrafish

Gene Tree: Perp

Human homologs

Human Homolog		PERP, PERP, TP53 apoptosis effector
NCBI Gene ID		64065
neXtProt AC		NX_Q96FX8
Human Synonyms		dJ496H19.1, KCP1, KRTCAP1, PIGPC1, RP3-496H19.1, THW
Human Chr (Location)		6q24; chr6:138409642-138428660 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygous inactivation of this locus results in increased lethality during the postnatal period.

 

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	activation of cysteine-type endopeptidase activity, amelogenesis, ...
Component	cell junction, cytoplasm, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (187)    Tissues (24)    Images (33)
Theiler Stages: 23, 28

Assay Type	Results
RNA in situ	187

cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(8) cDNA(8)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000019851 (Evidence)
Entrez Gene	64058 (Evidence)
DFCI	TC1573077
DoTS	DT.496632
NIA Mouse Gene Index	U011306
Consensus CDS Project	CCDS23714.1
International Mouse Knockout Project Status	Perp

Sequences

Length	Strain/Species
genomic	64058	NCBI Gene Model | MGI Sequence Detail	12003	C57BL/6J
transcript	NM_022032	RefSeq | MGI Sequence Detail	1901	C57BL/6
polypeptide	Q9JK95	UniProt | EBI | MGI Sequence Detail	193	Not Applicable

All sequences(19) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(86 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR015664	P53-induced protein
InterPro	IPR004031	PMP-22/EMP/MP20/Claudin
Protein Ontology	PR:000012551	p53 apoptosis effector related to PMP-22

Graphical View of Protein Domain Structure

References

(Earliest) J:67123 Attardi LD, et al., PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family. Genes Dev. 2000 Mar 15;14(6):704-18
(Latest) J:191121 Ferone G, et al., p63 control of desmosome gene expression and adhesion is compromised in AEC syndrome. Hum Mol Genet. 2013 Feb 1;22(3):531-43
All references(47)

Other accession IDs

MGI:1915072