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Perp Gene Detail
Summary
  • Symbol
    Perp
  • Name
    PERP, TP53 apoptosis effector
  • Synonyms
    1110017A08Rik, KCP1, KRTCAP1, PIGPC1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929938
    NCBI Gene: 64058
  • Gene Overview
    MyGene.info: PERP
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:18845071-18857073 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 7.97 cM, cytoband A2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    148 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929938
protein coding gene Chr10:18845020-18857073 (.)
129S1/SvImJ MGP_129S1SvImJ_G0017042
protein coding gene Chr10:16541395-16553369 (+)
A/J MGP_AJ_G0017020
protein coding gene Chr10:15911949-15923949 (+)
AKR/J MGP_AKRJ_G0016984
protein coding gene Chr10:16169920-16183237 (+)
BALB/cJ MGP_BALBcJ_G0016978
protein coding gene Chr10:15974356-15986613 (+)
C3H/HeJ MGP_C3HHeJ_G0016803
protein coding gene Chr10:16501181-16513114 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017440
protein coding gene Chr10:16944608-16956560 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015145
protein coding gene Chr10:14939713-14951579 (+)
CAST/EiJ MGP_CASTEiJ_G0016385
protein coding gene Chr10:16317120-16329398 (+)
CBA/J MGP_CBAJ_G0016775
protein coding gene Chr10:17708189-17722752 (+)
DBA/2J MGP_DBA2J_G0016883
protein coding gene Chr10:15800221-15812755 (+)
FVB/NJ MGP_FVBNJ_G0016878
protein coding gene Chr10:15560567-15572515 (+)
LP/J MGP_LPJ_G0016958
protein coding gene Chr10:16366135-16378045 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016908
protein coding gene Chr10:18013773-18025698 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017478
protein coding gene Chr10:16150372-16162335 (+)
PWK/PhJ MGP_PWKPhJ_G0016170
protein coding gene Chr10:15640775-15653512 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015953
protein coding gene Chr10:16301414-16313441 (+)
WSB/EiJ MGP_WSBEiJ_G0016447
protein coding gene Chr10:16246355-16259261 (+)



Homology
more
  • Human Ortholog
    PERP, PERP, TP53 apoptosis effector
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PERP, PERP, TP53 apoptosis effector
    Orthology source: HomoloGene, HGNC
  • Synonyms
    dJ496H19.1, KCP1, KRTCAP1, PIGPC1, THW
  • Links
    NCBI Gene ID: 64065
    neXtProt AC: NX_Q96FX8
    UniProt: Q96FX8

  • Chr Location
    6q23.3; chr6:138088505-138107523 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 11098
    1 human;1 mouse;1 rat;1 cattle;1 dog;2 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PERP
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this locus results in increased lethality during the postnatal period.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 64058 NCBI Gene Model | MGI Sequence Detail 12003 C57BL/6J ±  kb
    transcript NM_022032 RefSeq | MGI Sequence Detail 1901 C57BL/6  
    polypeptide Q9JK95 UniProt | EBI | MGI Sequence Detail 193 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 10
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1915072
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 13
      Gene Ontology 9
      Phenotypes 16
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:244304 Richardson R, et al., p63 exerts spatio-temporal control of palatal epithelial cell fate to prevent cleft palate. PLoS Genet. 2017 Jun;13(6):e1006828

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory