Automated description from the Alliance of Genome Resources (Release 7.1.0)
Involved in mammary gland duct morphogenesis and tissue homeostasis. Acts upstream of or within several processes, including amelogenesis; desmosome organization; and intrinsic apoptotic signaling pathway by p53 class mediator. Located in several cellular components, including Golgi apparatus; desmosome; and mitochondrion. Is expressed in several structures, including alimentary system; brain ventricle and choroid plexus; limb primordium; sensory organ; and skin. Human ortholog(s) of this gene implicated in erythrokeratodermia variabilis and mutilating palmoplantar keratoderma with periorificial keratotic plaques. Orthologous to human PERP (p53 apoptosis effector related to PMP22).