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Ncoa6
Gene Detail
Symbol

Name
ID
Ncoa6
nuclear receptor coactivator 6
MGI:1929915
Synonyms
AIB3, ASC2, ASC-2, mKIAA0181, NRC, PRIP, RAP250
Feature Type
protein coding gene
Genetic Map
Chromosome 2
77.26 cM, cytoband H2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:155390665-155473894 bp, - strand
From VEGA annotation of GRCm38

  83230 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:137337  Vertebrate Homology Class
1 mouse; 1 chicken; 1 western clawed frog

HCOP human homology predictions: NCOA6
Gene Tree: Ncoa6

Human
homologs
NCOA6, nuclear receptor coactivator 6
Orthology source: HGNC

IDs:
NCBI Gene ID: 23054
neXtProt AC: NX_Q14686

Human Synonyms: AIB3, ASC2, NRC, PRIP, RAP250, TRBP

Human Chr (Location): 20q11; chr20:34714774-34825630 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(28) : Endonuclease-mediated(1) Gene trapped(18) Targeted(9)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for targeted null mutations exhibit retarded embryonic growth and defects of the placenta, heart, liver, and nervous system. Mutants die around midgestation.
 
Phenotype Images(11)
Interactions
Ncoa6 interacts with 177 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process brain development, cellular response to DNA damage stimulus, ...
Component histone methyltransferase complex, nucleus, ...
Function chromatin binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (272)    Tissues (176)    Images (53)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 252
RT-PCR 20
cDNA source data(182)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ncoa6 ; ZFIN ncoa6    NEW 
Molecular
reagents
All nucleic(186) Genomic(1) cDNA(182) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000016062 (Evidence)
Ensembl Gene Model ENSMUSG00000038369 (Evidence)
Entrez Gene 56406 (Evidence)
UniGene 27592
DFCI TC1729422, TC1575070
DoTS DT.97366040, DT.94340170, DT.94340155, DT.533596, DT.110679714, DT.103552073
NIA Mouse Gene Index U023534
Consensus CDS Project CCDS38295.1
International Mouse Phenotyping Consortium Status Ncoa6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016062 VEGA Gene Model | MGI Sequence Detail 83230 C57BL/6J ±  kb
transcript OTTMUST00000038342 VEGA | MGI Sequence Detail 7101 Not Applicable 
polypeptide OTTMUSP00000017183 VEGA | MGI Sequence Detail 2069 Not Applicable 

For the selected sequences
All sequences(75) RefSeq(12) UniProt(10)
Polymorphisms
SNPs within 2kb(337 from dbSNP Build 137)    SNPs within 2kb including multiple locations(341)
Protein-related
information
ResourceIDDescription
InterPro IPR026638 Nuclear receptor coactivator 6
Protein Ontology PR:000011045 nuclear receptor coactivator 6
References
(Earliest) J:60556 Caira F, et al., Cloning and characterization of RAP250, a novel nuclear receptor coactivator. J Biol Chem. 2000 Feb 25;275(8):5308-17
(Latest) J:191304 Kim GH, et al., Regulation of hepatic insulin sensitivity by activating signal co-integrator-2. Biochem J. 2012 Nov 1;447(3):437-47
All references(51)
Other
accession IDs
MGI:1355304

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory