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Ncoa6
Gene Detail
 Symbol
Name
ID
Ncoa6
nuclear receptor coactivator 6
MGI:1929915
Synonyms AIB3, ASC2, ASC-2, mKIAA0181, NRC, PRIP, RAP250
Feature Type protein coding gene
Genetic Map
Chromosome 2
77.26 cM, cytoband H2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:155390665-155473894 bp, - strand
From VEGA annotation of GRCm38

  83230 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:137337  Vertebrate Homology Class
1 mouse; 1 chicken; 1 western clawed frog

Gene Tree: Ncoa6

Mutations,
alleles, and
phenotypes
All mutations/alleles(27) : Gene trapped(18) Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit retarded embryonic growth and defects of the placenta, heart, liver, and nervous system. Mutants die around midgestation.
 
Phenotype Images(11)
Interactions
Ncoa6 interacts with 177 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process brain development, cellular response to DNA damage stimulus, ...
Component histone methyltransferase complex, nucleus, ...
Function chromatin binding, transcription coactivator activity
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (272)    Tissues (176)    Images (53)
Theiler Stages: 4, 14, 17, 19, 20, 22, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 252
RT-PCR 20
cDNA source data(182)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(186) Genomic(1) cDNA(182) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000016062 (Evidence)
Ensembl Gene ModelENSMUSG00000038369 (Evidence)
Entrez Gene56406 (Evidence)
UniGene27592
DFCITC1575070, TC1729422
DoTSDT.103552073, DT.110679714, DT.533596, DT.94340155, DT.94340170, DT.97366040
NIA Mouse Gene IndexU023534
Consensus CDS ProjectCCDS38295.1
International Mouse Knockout Project StatusNcoa6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016062 VEGA Gene Model | MGI Sequence Detail 83230 C57BL/6J ±  kb
transcript OTTMUST00000038342 VEGA | MGI Sequence Detail 7101 Not Applicable 
polypeptide OTTMUSP00000017183 VEGA | MGI Sequence Detail 2069 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(10) UniProt(10)
Polymorphisms SNPs within 2kb(337 from dbSNP Build 137)    SNPs within 2kb including multiple locations(341)
Protein-related
information
ResourceIDDescription
InterPro IPR026638 Nuclear receptor coactivator 6
Protein Ontology PR:000011045 nuclear receptor coactivator 6
References (Earliest) J:60556 Caira F, et al., Cloning and characterization of RAP250, a novel nuclear receptor coactivator. J Biol Chem. 2000 Feb 25;275(8):5308-17
(Latest) J:191304 Kim GH, et al., Regulation of hepatic insulin sensitivity by activating signal co-integrator-2. Biochem J. 2012 Nov 1;447(3):437-47
All references(51)
Other
accession IDs
MGI:1355304

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory