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Ncoa6 Gene Detail
Summary
  • Symbol
    Ncoa6
  • Name
    nuclear receptor coactivator 6
  • Synonyms
    AIB3, ASC2, ASC-2, mKIAA0181, NRC, PRIP, RAP250
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929915
    NCBI Gene: 56406
  • Gene Overview
    MyGene.info: NCOA6
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:155390656-155473894 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 77.26 cM, cytoband H2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    335 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929915
protein coding gene Chr2:155390656-155473894 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026734
protein coding gene Chr2:160207075-160295320 (-)
A/J MGP_AJ_G0026700
protein coding gene Chr2:153839767-153927908 (-)
AKR/J MGP_AKRJ_G0026671
protein coding gene Chr2:158303864-158395283 (-)
BALB/cJ MGP_BALBcJ_G0026709
protein coding gene Chr2:154141466-154226568 (-)
C3H/HeJ MGP_C3HHeJ_G0026452
protein coding gene Chr2:158661714-158750983 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027158
protein coding gene Chr2:164901382-165001050 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024528
protein coding gene Chr2:147342497-147426612 (-)
CAST/EiJ MGP_CASTEiJ_G0025913
protein coding gene Chr2:158970453-159067603 (-)
CBA/J MGP_CBAJ_G0026429
protein coding gene Chr2:170900064-170995841 (-)
DBA/2J MGP_DBA2J_G0026566
protein coding gene Chr2:153022688-153109359 (-)
FVB/NJ MGP_FVBNJ_G0026533
protein coding gene Chr2:151403605-151486747 (-)
LP/J MGP_LPJ_G0026671
protein coding gene Chr2:160349096-160445461 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026554
protein coding gene Chr2:174902435-174990990 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027214
protein coding gene Chr2:158192425-158282172 (-)
PWK/PhJ MGP_PWKPhJ_G0025647
protein coding gene Chr2:152524066-152607811 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025450
protein coding gene Chr2:157116918-157208051 (-)
WSB/EiJ MGP_WSBEiJ_G0025983
protein coding gene Chr2:159079495-159165698 (-)



Homology
more
  • Human Ortholog
    NCOA6, nuclear receptor coactivator 6
  • Vertebrate Orthologs
    3
  • Human Ortholog
    NCOA6, nuclear receptor coactivator 6
    Orthology source: HGNC
  • Synonyms
    AIB3, ASC2, NRC, PRIP, RAP250, TRBP
  • Links
    NCBI Gene ID: 23054
    neXtProt AC: NX_Q14686
    UniProt: Q14686

  • Chr Location
    20q11.22; chr20:34714774-34825649 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    93 phenotypes from 9 alleles in 11 genetic backgrounds
    1 phenotype from multigenic genotypes
    11 images
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit retarded embryonic growth and defects of the placenta, heart, liver, and nervous system. Mutants die around midgestation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56406 NCBI Gene Model | MGI Sequence Detail 83239 C57BL/6J ±  kb
    transcript NM_019825 RefSeq | MGI Sequence Detail 6872 C57BL/6  
    polypeptide Q9JL19 UniProt | EBI | MGI Sequence Detail 2067 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • InterPro Domains
      IPR026638 Nuclear receptor coactivator 6
      IPR032715 Nuclear receptor coactivator 6, putative nucleic acid-binding region
    Molecular
    Reagents
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    • All nucleic 187
      Genomic 1
      cDNA 183
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1355304
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 9
      Gene Ontology 9
      Phenotypes 22
    • Earliest
      J:60556 Caira F, et al., Cloning and characterization of RAP250, a novel nuclear receptor coactivator. J Biol Chem. 2000 Feb 25;275(8):5308-17
    • Latest
      J:250797 Yoon J, et al., Regulation of Nampt expression by transcriptional coactivator NCOA6 in pancreatic beta-cells. Biochem Biophys Res Commun. 2017 Jun 3;487(3):600-606

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory