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Smoc1 Gene Detail
Summary
  • Symbol
    Smoc1
  • Name
    SPARC related modular calcium binding 1
  • Synonyms
    2600002F22Rik, SPARC-related protein, SRG
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929878
    NCBI Gene: 64075
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:81073582-81233188 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 12, 37.28 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    769 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929878
protein coding gene Chr12:81073582-81233188 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019897
protein coding gene Chr12:81452535-81633782 (+)
A/J MGP_AJ_G0019855
protein coding gene Chr12:78474258-78637472 (+)
AKR/J MGP_AKRJ_G0019830
protein coding gene Chr12:80618306-80793862 (+)
BALB/cJ MGP_BALBcJ_G0019834
protein coding gene Chr12:78721057-78883161 (+)
C3H/HeJ MGP_C3HHeJ_G0019640
protein coding gene Chr12:81088769-81258163 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020286
protein coding gene Chr12:83833242-84016704 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017905
protein coding gene Chr12:75469226-75628258 (+)
CAST/EiJ MGP_CASTEiJ_G0019190
protein coding gene Chr12:75959205-76129551 (+)
CBA/J MGP_CBAJ_G0019611
protein coding gene Chr12:87093933-87279354 (+)
DBA/2J MGP_DBA2J_G0019726
protein coding gene Chr12:78081641-78241562 (+)
FVB/NJ MGP_FVBNJ_G0019712
protein coding gene Chr12:76905188-77066697 (+)
LP/J MGP_LPJ_G0019798
protein coding gene Chr12:81360199-81535823 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019751
protein coding gene Chr12:90087347-90271430 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020321
protein coding gene Chr12:80152075-80321752 (+)
PWK/PhJ MGP_PWKPhJ_G0018956
protein coding gene Chr12:72483009-72648285 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018750
protein coding gene Chr12:74667795-74840924 (+)
WSB/EiJ MGP_WSBEiJ_G0019243
protein coding gene Chr12:80787330-80963630 (+)



Homology
more
  • Human Ortholog
    SMOC1, SPARC related modular calcium binding 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SMOC1, SPARC related modular calcium binding 1
  • Synonyms
    OAS
  • Links
    NCBI Gene ID: 64093
    neXtProt AC: NX_Q9H4F8
    UniProt: Q9H4F8

  • Chr Location
    14q24.2; chr14:69854131-70032366 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with Smoc1 mouse models; 1 with human SMOC1 associations

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    56 phenotypes from 3 alleles in 5 genetic backgrounds
    3 images
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a transposon-induced allele exhibit ocular and limb defects. Mice homozygous for a knock-out allele exhibit neonatal lethality, osseous syndactyly, decreased body size, and iris and retina coloboma.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 64075 NCBI Gene Model | MGI Sequence Detail 159607 C57BL/6J ±  kb
    transcript NM_001146217 RefSeq | MGI Sequence Detail 3496 C57BL/6  
    polypeptide Q8BLY1 UniProt | EBI | MGI Sequence Detail 463 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 80
      Genomic 1
      cDNA 71
      Primer pair 7
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1917142, MGI:2144899
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 20
      Diseases 2
      Gene Ontology 6
      Phenotypes 20
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:324527 Matoba S, et al., Noncanonical imprinting sustains embryonic development and restrains placental overgrowth. Genes Dev. 2022 Apr 1;36(7-8):483-494

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory