Smoc1
Gene Detail

Symbol Name ID

Smoc1 SPARC related modular calcium binding 1 MGI:1929878

Synonyms

2600002F22Rik, SPARC-related protein, SRG

Feature Type

protein coding gene

Genetic Map

Chromosome 12

37.28 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr12:81026808-81186414 bp, + strand From VEGA annotation of GRCm38   159607 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:56943  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Smoc1

Human homologs

Human Homolog		SMOC1, SPARC related modular calcium binding 1
NCBI Gene ID		64093
neXtProt AC		NX_Q9H4F8
Human Synonyms		OAS
Human Chr (Location)		14q24.2; chr14:70346114-70499083 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SMOC1

Alleles and phenotypes

All alleles(11) : Targeted(2) Gene trapped(8) Transposon induced(1)
 

Mice homozygous for a transposon-induced allele exhibit ocular and limb defects. Mice homozygous for a knock-out allele exhibit neonatal lethality, osseous syndactyly, decreased body size, and iris and retina coloboma.

 
Human Diseases Modeled Using Mouse Smoc1 (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	cell differentiation, extracellular matrix organization, ...
Component	basement membrane, extracellular region, ...
Function	calcium ion binding, extracellular matrix binding, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (303)    Tissues (54)    Images (28)
Theiler Stages: 11, 13, 23, 24

Assay Type	Results
Immunohistochemistry	3
RNA in situ	300

cDNA source data(65)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(65) cDNA(65)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000033861 (Evidence)
Ensembl Gene Model	ENSMUSG00000021136 (Evidence)
Entrez Gene	64075 (Evidence)
UniGene	273295
DFCI	TC1576531
DoTS	DT.533988, DT.91357291
NIA Mouse Gene Index	U014157
Consensus CDS Project	CCDS26017.1, CCDS49102.1
International Mouse Knockout Project Status	Smoc1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033861	VEGA Gene Model | MGI Sequence Detail	159607	C57BL/6J
transcript	OTTMUST00000085342	VEGA | MGI Sequence Detail	3496	Not Applicable
polypeptide	OTTMUSP00000046098	VEGA | MGI Sequence Detail	463	Not Applicable

All sequences(34) RefSeq(4) UniProt(3)

Polymorphisms

SNPs(611 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR018247	EF-Hand 1, calcium-binding site
InterPro	IPR011992	EF-hand-like domain
InterPro	IPR011497	Kazal-type serine protease inhibitor domain
InterPro	IPR002350	Proteinase inhibitor I1, Kazal
InterPro	IPR019577	SPARC/Testican, calcium-binding domain
InterPro	IPR000716	Thyroglobulin type-1
Protein Ontology	PR:000015289	SPARC-related modular calcium-binding protein 1

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:178642 Slavotinek AM, Eye development genes and known syndromes. Mol Genet Metab. 2011 Dec;104(4):448-56
All references(46)

Other accession IDs

MGI:1917142, MGI:2144899