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Smoc1
Gene Detail
 Symbol
Name
ID
Smoc1
SPARC related modular calcium binding 1
MGI:1929878
Synonyms 2600002F22Rik, SPARC-related protein, SRG
Feature Type protein coding gene
Genetic Map
Chromosome 12
37.28 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:81026808-81186414 bp, + strand
From VEGA annotation of GRCm38

  159607 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56943  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Smoc1

Human
homologs
Human Homolog SMOC1, SPARC related modular calcium binding 1
NCBI Gene ID 64093
neXtProt AC  NX_Q9H4F8
Human Synonyms  OAS
Human Chr (Location)  14q24.2; chr14:69879388-70032366 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human SMOC1
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(8) Targeted(3) Transposon induced(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a transposon-induced allele exhibit ocular and limb defects. Mice homozygous for a knock-out allele exhibit neonatal lethality, osseous syndactyly, decreased body size, and iris and retina coloboma.
 
Human Diseases Modeled Using Mouse Smoc1 (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(3)
Interactions
Smoc1 interacts with 274 markers (Mir1b, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process cell differentiation, extracellular matrix organization, ...
Component basement membrane, extracellular region, ...
Function calcium ion binding, extracellular matrix binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (435)    Tissues (98)    Images (63)
Theiler Stages: 11, 13, 17, 18, 19, 20, 21, 22, 23, 24
Assay TypeResults
Immunohistochemistry 3
RNA in situ 368
RT-PCR 64
cDNA source data(67)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(68) cDNA(67) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000033861 (Evidence)
Ensembl Gene ModelENSMUSG00000021136 (Evidence)
Entrez Gene64075 (Evidence)
UniGene273295
DFCITC1576531
DoTSDT.533988, DT.91357291
NIA Mouse Gene IndexU014157
Consensus CDS ProjectCCDS26017.1, CCDS49102.1
International Mouse Knockout Project StatusSmoc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033861 VEGA Gene Model | MGI Sequence Detail 159607 C57BL/6J ±  kb
transcript OTTMUST00000085342 VEGA | MGI Sequence Detail 3496 Not Applicable 
polypeptide OTTMUSP00000046098 VEGA | MGI Sequence Detail 463 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(6) UniProt(3)
Polymorphisms SNPs within 2kb(776 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR011992 EF-hand-like domain
InterPro IPR002350 Kazal domain
InterPro IPR019577 SPARC/Testican, calcium-binding domain
InterPro IPR000716 Thyroglobulin type-1
Protein Ontology PR:000015289 SPARC-related modular calcium-binding protein 1
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:178642 Slavotinek AM, Eye development genes and known syndromes. Mol Genet Metab. 2011 Dec;104(4):448-56
All references(47)
Disease annotation references (2)
Other
accession IDs
MGI:1917142, MGI:2144899

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory