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Smoc1 Gene Detail
Summary
  • Symbol
    Smoc1
  • Name
    SPARC related modular calcium binding 1
  • Synonyms
    2600002F22Rik, SPARC-related protein, SRG
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929878
    NCBI Gene: 64075
Location & Maps
more
  • Sequence Map
    Chr12:81026808-81186414 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      159607 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 37.28 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SMOC1, SPARC related modular calcium binding 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SMOC1, SPARC related modular calcium binding 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    OAS
  • Links
    NCBI Gene ID: 64093
    neXtProt AC: NX_Q9H4F8

  • Chr Location
    14q24.2; chr14:69879388-70032366 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 56943
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: SMOC1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Smoc1 mouse models; 1 with human SMOC1 associations

Human Disease Mouse Models
       Microphthalmia with Limb Anomalies; MLA   OMIM: 206920 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    40 phenotypes from 3 alleles in 5 genetic backgrounds
    3 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    1
  • Gene trapped
    8
  • Targeted
    3
  • Transposon induced
    1
  • Genomic Mutations
    1 involving Smoc1
  • Incidental Mutations
Mice homozygous for a transposon-induced allele exhibit ocular and limb defects. Mice homozygous for a knock-out allele exhibit neonatal lethality, osseous syndactyly, decreased body size, and iris and retina coloboma.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033861 VEGA Gene Model | MGI Sequence Detail 159607 C57BL/6J ±  kb
transcript OTTMUST00000085342 VEGA | MGI Sequence Detail 3496 Not Applicable  
polypeptide OTTMUSP00000046098 VEGA | MGI Sequence Detail 463 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    769 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 68
    cDNA 67
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1917142, MGI:2144899
References
more
  • Summaries
    All 45
    Developmental Gene Expression 13
    Diseases 2
    Gene Ontology 5
    Phenotypes 14
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:228726 Golonzhka O, et al., Pbx Regulates Patterning of the Cerebral Cortex in Progenitors and Postmitotic Neurons. Neuron. 2015 Dec 16;88(6):1192-207

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory