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Hic2
Gene Detail
Symbol

Name
ID
Hic2
hypermethylated in cancer 2
MGI:1929869
Synonyms
HRG22, mKIAA1020
Feature Type
protein coding gene
Genetic Map
Chromosome 16
10.68 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:17233572-17263430 bp, + strand
From VEGA annotation of GRCm38

  29859 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9020  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: HIC2
Gene Tree: Hic2

Human
homologs
HIC2, hypermethylated in cancer 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 23119
neXtProt AC: NX_Q96JB3

Human Synonyms: HRG22, ZBTB30, ZNF907

Human Chr (Location): 22q11.21; chr22:21417404-21451463 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(408) : Gene trapped(406) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Hic2 interacts with 429 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process regulation of transcription, DNA-templated, transcription, DNA-templated
Component nucleoplasm, nucleus, ...
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (133)    Tissues (131)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 133
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase hic2 ; ZFIN hic2    NEW 
Molecular
reagents
All nucleic(17) cDNA(17)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000038081 (Evidence)
Ensembl Gene Model ENSMUSG00000050240 (Evidence)
Entrez Gene 58180 (Evidence)
DFCI TC1581906, TC1585251, TC1598038
DoTS DT.110711209, DT.101373844, DT.485939
NIA Mouse Gene Index U043499
Consensus CDS Project CCDS27999.1
International Mouse Phenotyping Consortium Status Hic2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000038081 VEGA Gene Model | MGI Sequence Detail 29859 C57BL/6J ±  kb
transcript OTTMUST00000098095 VEGA | MGI Sequence Detail 6354 Not Applicable 
polypeptide OTTMUSP00000055061 VEGA | MGI Sequence Detail 619 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(48 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013069 BTB/POZ
InterPro IPR011333 BTB/POZ fold
InterPro IPR000210 BTB/POZ-like
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000008552 hypermethylated in cancer 2 protein
References
(Earliest) J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
(Latest) J:198566 Gurtan AM, et al., Let-7 represses Nr6a1 and a mid-gestation developmental program in adult fibroblasts. Genes Dev. 2013 Apr 15;27(8):941-54
All references(40)
Other
accession IDs
MGI:2146339

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory