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Hic2 Gene Detail
Summary
  • Symbol
    Hic2
  • Name
    hypermethylated in cancer 2
  • Synonyms
    HRG22, mKIAA1020
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929869
    NCBI Gene: 58180
  • Gene Overview
    MyGene.info: HIC2
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:17233587-17263430 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 10.68 cM, cytoband B1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    62 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929869
protein coding gene Chr16:17233572-17263430 (.)
129S1/SvImJ MGP_129S1SvImJ_G0022575
protein coding gene Chr16:14368943-14400803 (+)
A/J MGP_AJ_G0022536
protein coding gene Chr16:13656959-13686781 (+)
AKR/J MGP_AKRJ_G0022513
protein coding gene Chr16:14203162-14233006 (+)
BALB/cJ MGP_BALBcJ_G0022539
protein coding gene Chr16:13800285-13830063 (+)
C3H/HeJ MGP_C3HHeJ_G0022306
protein coding gene Chr16:14337493-14368330 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022990
protein coding gene Chr16:14598816-14629732 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020510
protein coding gene Chr16:13732151-13761946 (+)
CAST/EiJ MGP_CASTEiJ_G0021834
protein coding gene Chr16:14240188-14273911 (+)
CBA/J MGP_CBAJ_G0022277
protein coding gene Chr16:15277308-15309276 (+)
DBA/2J MGP_DBA2J_G0022407
protein coding gene Chr16:13581551-13611449 (+)
FVB/NJ MGP_FVBNJ_G0022383
protein coding gene Chr16:13622943-13652899 (+)
LP/J MGP_LPJ_G0022474
protein coding gene Chr16:14134079-14163983 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022404
protein coding gene Chr16:14955422-14986263 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023001
protein coding gene Chr16:14134716-14164557 (+)
PWK/PhJ MGP_PWKPhJ_G0021577
protein coding gene Chr16:13825717-13856095 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021405
protein coding gene Chr16:14122697-14152368 (+)
WSB/EiJ MGP_WSBEiJ_G0021881
protein coding gene Chr16:14137124-14166848 (+)



Homology
more
  • Human Ortholog
    HIC2, HIC ZBTB transcriptional repressor 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    HIC2, HIC ZBTB transcriptional repressor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HRG22, ZBTB30, ZNF907
  • Links
    NCBI Gene ID: 23119
    neXtProt AC: NX_Q96JB3
    UniProt: Q96JB3

  • Chr Location
    22q11.21; chr22:21417402-21451463 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 9020
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: HIC2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 4 alleles in 6 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene results in embryonic lethality. A subset of mice heterozygous for a knock-out allele exhibit prenatal lethality and cardiac defects including a ventricular septal defect with overriding aortic valve, and thin myocardial and trabecular layers.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 58180 NCBI Gene Model | MGI Sequence Detail 29844 C57BL/6J ±  kb
    transcript NM_178922 RefSeq | MGI Sequence Detail 6360 Not Specified  
    polypeptide Q9JLZ6 UniProt | EBI | MGI Sequence Detail 619 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 18

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2146339
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 6
      Gene Ontology 5
      Phenotypes 6
    • Earliest
      J:67201 Mannan A, et al., Alternative splicing, chromosome assignment and subcellular localization of the testicular haploid expressed gene (THEG). Cytogenet Cell Genet. 2000;91(1-4):171-9
    • Latest
      J:257501 Dykes IM, et al., HIC2 regulates isoform switching during maturation of the cardiovascular system. J Mol Cell Cardiol. 2018 Jan;114:29-37

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory