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Hic2 Gene Detail
Summary
  • Symbol
    Hic2
  • Name
    hypermethylated in cancer 2
  • Synonyms
    HRG22, mKIAA1020
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929869
    NCBI Gene: 58180
  • Gene Overview
    MyGene.info: HIC2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr16:17233572-17263430 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      29859 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 10.68 cM, cytoband B1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    HIC2, HIC ZBTB transcriptional repressor 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    HIC2, HIC ZBTB transcriptional repressor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HRG22, ZBTB30, ZNF907
  • Links
    NCBI Gene ID: 23119
    neXtProt AC: NX_Q96JB3
    UniProt: Q96JB3

  • Chr Location
    22q11.21; chr22:21417402-21451463 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 9020
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: HIC2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 4 alleles in 6 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene results in embryonic lethality. A subset of mice heterozygous for a knock-out allele exhibit prenatal lethality and cardiac defects including a ventricular septal defect with overriding aortic valve, and thin myocardial and trabecular layers.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000038081 VEGA Gene Model | MGI Sequence Detail 29859 C57BL/6J ±  kb
    transcript OTTMUST00000098095 VEGA | MGI Sequence Detail 6354 Not Applicable  
    polypeptide OTTMUSP00000055061 VEGA | MGI Sequence Detail 619 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      62 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 17

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2146339
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 6
      Gene Ontology 3
      Phenotypes 10
    • Earliest
      J:67201 Mannan A, et al., Alternative splicing, chromosome assignment and subcellular localization of the testicular haploid expressed gene (THEG). Cytogenet Cell Genet. 2000;91(1-4):171-9
    • Latest
      J:257501 Dykes IM, et al., HIC2 regulates isoform switching during maturation of the cardiovascular system. J Mol Cell Cardiol. 2018 Jan;114:29-37

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory