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Nampt Gene Detail
Summary
  • Symbol
    Nampt
  • Name
    nicotinamide phosphoribosyltransferase
  • Synonyms
    1110035O14Rik, Pbef1, Visfatin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929865
    NCBI Gene: 59027
  • Alliance
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:32820335-32853369 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 13.74 cM, cytoband B1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    265 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929865
protein coding gene Chr12:32819545-32853369 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019671
protein coding gene Chr12:30852511-30891954 (+)
A/J MGP_AJ_G0019638
protein coding gene Chr12:29936406-29969335 (+)
AKR/J MGP_AKRJ_G0019609
protein coding gene Chr12:30911882-30946114 (+)
BALB/cJ MGP_BALBcJ_G0019615
protein coding gene Chr12:30158063-30195450 (+)
C3H/HeJ MGP_C3HHeJ_G0019419
protein coding gene Chr12:30764662-30797070 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020062
protein coding gene Chr12:31782704-31816635 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017687
protein coding gene Chr12:29235147-29269583 (+)
CAST/EiJ MGP_CASTEiJ_G0018974
protein coding gene Chr12:25797008-25831189 (+)
CBA/J MGP_CBAJ_G0019391
protein coding gene Chr12:32803193-32837400 (+)
DBA/2J MGP_DBA2J_G0019504
protein coding gene Chr12:29764823-29798437 (+)
FVB/NJ MGP_FVBNJ_G0019495
protein coding gene Chr12:29549328-29582843 (+)
LP/J MGP_LPJ_G0019574
protein coding gene Chr12:30935061-30974387 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019530
protein coding gene Chr12:32433023-32474331 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020102
protein coding gene Chr12:30417464-30450529 (+)
PWK/PhJ MGP_PWKPhJ_G0018741
protein coding gene Chr12:24524746-24557580 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018529
protein coding gene Chr12:25028277-25060704 (+)
WSB/EiJ MGP_WSBEiJ_G0019024
protein coding gene Chr12:30657614-30692286 (+)



Homology
more
  • Human Ortholog
    NAMPT, nicotinamide phosphoribosyltransferase
  • Vertebrate Orthologs
    15
  • Human Ortholog
    NAMPT, nicotinamide phosphoribosyltransferase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    1110035O14Rik, PBEF, PBEF1, VF, VISFATIN
  • Links
    NCBI Gene ID: 10135
    neXtProt AC: NX_P43490
    UniProt: P43490

  • Chr Location
    7q22.3; chr7:106248285-106285732 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 4 alleles in 4 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit embryonic lethality prior to E10.5. Mice heterozygous for a null allele exhibit increased fasted glucose in male mice and impaired glucose tolerance and decresed glucose-stimulated insulin secretion in female mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 59027 NCBI Gene Model | MGI Sequence Detail 33035 C57BL/6J ±  kb
    transcript NM_021524 RefSeq | MGI Sequence Detail 4547 C57BL/6  
    polypeptide Q99KQ4 UniProt | EBI | MGI Sequence Detail 491 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 173
      cDNA 173

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1915933, MGI:2144781, MGI:2144846
    References
    more
    • Summaries
      All 80
      Developmental Gene Expression 6
      Gene Ontology 8
      Phenotypes 26
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:264750 Zhang LQ, et al., Novel Protective Role of Nicotinamide Phosphoribosyltransferase in Acetaminophen-Induced Acute Liver Injury in Mice. Am J Pathol. 2018 Jul;188(7):1640-1652

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory