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Arl3
Gene Detail
Symbol

Name
ID
Arl3
ADP-ribosylation factor-like 3
MGI:1929699
Feature Type
protein coding gene
Genetic Map
Chromosome 19
38.94 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr19:46531109-46573085 bp, - strand
From Ensembl annotation of GRCm38

  41977 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48276  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: ADP-ribosylation factor
Gene Tree: Arl3

Human
homologs
Human Homolog ARL3, ADP-ribosylation factor-like 3
NCBI Gene ID 403
neXtProt AC  NX_P36405
Human Synonyms  ARFL3
Human Chr (Location)  10q23.3; chr10:102673727-102714433 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(71) : Gene trapped(71)
 
Mice homozygous for a gene trapped allele are born at sub-Mendelian ratios, are small and sickly, fail to thrive, and die by 3 weeks of age exhibiting photoreceptor degeneration and abnormal epithelial cell proliferation and cyst formation in the kidney, liver, and pancreatic tubule structures.
 
Human Diseases Modeled Using Mouse Arl3 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Arl3 interacts with 56 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process cell cycle, cell division, ...
Component cell, cell projection, ...
Function GDP binding, GTPase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (8)    Tissues (4)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 8
cDNA source data(99)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(100) cDNA(100)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000025035 (Evidence)
Entrez Gene56350 (Evidence)
UniGene22085
DFCITC1576680
DoTSDT.534757
NIA Mouse Gene IndexU039113
PDB4GOJ, 1FZQ, 3BH6, 3BH7
Consensus CDS ProjectCCDS38010.1
International Mouse Knockout Project StatusArl3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025035 Ensembl Gene Model | MGI Sequence Detail 41977 C57BL/6J ±  kb
transcript ENSMUST00000026009 Ensembl | MGI Sequence Detail 822 Not Applicable 
polypeptide ENSMUSP00000026009 Ensembl | MGI Sequence Detail 182 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(389 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR006689 Small GTPase superfamily, ARF/SAR type
InterPro IPR024156 Small GTPase superfamily, ARF type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000004284 ADP-ribosylation factor-like protein 3
References
(Earliest) J:66311 Linari M, et al., The delta subunit of rod specific cyclic GMP phosphodiesterase, PDE delta, interacts with the Arf-like protein Arl3 in a GTP specific manner. FEBS Lett. 1999 Sep 10;458(1):55-9
(Latest) J:200445 Watzlich D, et al., The interplay between RPGR, PDEdelta and Arl2/3 regulate the ciliary targeting of farnesylated cargo. EMBO Rep. 2013 May;14(5):465-72
All references(39)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory