Arl3
Gene Detail

Symbol Name ID

Arl3 ADP-ribosylation factor-like 3 MGI:1929699

Feature Type

protein coding gene

Genetic Map

Chromosome 19

38.94 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr19:46531109-46573085 bp, - strand From NCBI annotation of GRCm38   41977 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:48276  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: ADP-ribosylation factor
Gene Tree: Arl3

Human homologs

Human Homolog		ARL3, ADP-ribosylation factor-like 3
NCBI Gene ID		403
neXtProt AC		NX_P36405
Human Synonyms		ARFL3
Human Chr (Location)		10q23.3; chr10:104433484-104474190 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(71) : Gene trapped(71)
 

Mice homozygous for a gene trapped allele are born at sub-Mendelian ratios, are small and sickly, fail to thrive, and die by 3 weeks of age exhibiting photoreceptor degeneration and abnormal epithelial cell proliferation and cyst formation in the kidney, liver, and pancreatic tubule structures.

 
Human Diseases Modeled Using Mouse Arl3 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (36 annotations)

Process	cell cycle, cell division, ...
Component	cell projection, centrosome, ...
Function	GDP binding, GTPase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (8)    Tissues (4)    Images (3)
Theiler Stages: 28

Assay Type	Results
RNA in situ	8

cDNA source data(100)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(101) cDNA(101)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000025035 (Evidence)
Entrez Gene	56350 (Evidence)
UniGene	22085
DFCI	TC1576680
DoTS	DT.534757
NIA Mouse Gene Index	U039113
PDB	1FZQ, 4GOJ, 3BH6, 3BH7
Consensus CDS Project	CCDS38010.1
International Mouse Knockout Project Status	Arl3

Sequences

Length	Strain/Species
genomic	56350	NCBI Gene Model | MGI Sequence Detail	41977	C57BL/6J
transcript	NM_019718	RefSeq | MGI Sequence Detail	838	Not Specified
polypeptide	Q9WUL7	UniProt | EBI | MGI Sequence Detail	182	Not Applicable

All sequences(18) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(200 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006689	Small GTPase superfamily, ARF/SAR type
InterPro	IPR024156	Small GTPase superfamily, ARF type
InterPro	IPR005225	Small GTP-binding protein domain
Protein Ontology	PR:000004284	ADP-ribosylation factor-like protein 3

Graphical View of Protein Domain Structure

References

(Earliest) J:66311 Linari M, et al., The delta subunit of rod specific cyclic GMP phosphodiesterase, PDE delta, interacts with the Arf-like protein Arl3 in a GTP specific manner. FEBS Lett. 1999 Sep 10;458(1):55-9
(Latest) J:182871 Lai CK, et al., Functional characterization of putative cilia genes by high-content analysis. Mol Biol Cell. 2011 Apr;22(7):1104-19
All references(37)