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Arl3 Gene Detail
Summary
  • Symbol
    Arl3
  • Name
    ADP-ribosylation factor-like 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929699
    NCBI Gene: 56350
  • Gene Overview
    MyGene.info: ARL3
Location & Maps
more
  • Sequence Map
    Chr19:46531109-46573085 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      41977 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ARL3, ADP ribosylation factor like GTPase 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ARL3, ADP ribosylation factor like GTPase 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ARFL3
  • Links
    NCBI Gene ID: 403
    neXtProt AC: NX_P36405

  • Chr Location
    10q23.3; chr10:102673727-102714433 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Arl3 mouse models

Human Disease Mouse Models
       Polycystic Kidney Disease, Autosomal Recessive; ARPKD   OMIM: 263200 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    71
  • Gene trapped
    71
Mice homozygous for a gene trapped allele are born at sub-Mendelian ratios, are small and sickly, fail to thrive, and die by 3 weeks of age exhibiting photoreceptor degeneration and abnormal epithelial cell proliferation and cyst formation in the kidney,liver, and pancreatic tubule structures.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025035 Ensembl Gene Model | MGI Sequence Detail 41977 C57BL/6J ±  kb
transcript ENSMUST00000026009 Ensembl | MGI Sequence Detail 822 Not Applicable  
polypeptide ENSMUSP00000026009 Ensembl | MGI Sequence Detail 182 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    385 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 100
    cDNA 100

    Microarray probesets 2
References
more
  • Summaries
    All 36
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 12
    Phenotypes 7
  • Earliest
    J:66311 Linari M, et al., The delta subunit of rod specific cyclic GMP phosphodiesterase, PDE delta, interacts with the Arf-like protein Arl3 in a GTP specific manner. FEBS Lett. 1999 Sep 10;458(1):55-9
  • Latest
    J:228071 Gotthardt K, et al., A G-protein activation cascade from Arl13B to Arl3 and implications for ciliary targeting of lipidated proteins. Elife. 2015;4

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory