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Hacl1 Gene Detail
Summary
  • Symbol
    Hacl1
  • Name
    2-hydroxyacyl-CoA lyase 1
  • Synonyms
    1600020H07Rik, Hpcl, Phyh2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929657
    NCBI Gene: 56794
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr14:31607226-31640965 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 19.23 cM, cytoband B
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    214 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929657
protein coding gene Chr14:31552905-31641286 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021132
protein coding gene Chr14:24743221-24835885 (-)
A/J MGP_AJ_G0021080
protein coding gene Chr14:23809589-23901284 (-)
AKR/J MGP_AKRJ_G0021057
protein coding gene Chr14:24934352-25024148 (-)
BALB/cJ MGP_BALBcJ_G0021084
protein coding gene Chr14:23941562-24033270 (-)
C3H/HeJ MGP_C3HHeJ_G0020867
protein coding gene Chr14:24804635-24895916 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021516
protein coding gene Chr14:25717697-25815691 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019079
protein coding gene Chr14:23881520-23969144 (-)
CAST/EiJ MGP_CASTEiJ_G0020392
protein coding gene Chr14:24596721-24688402 (-)
CBA/J MGP_CBAJ_G0020834
protein coding gene Chr14:26691266-26792127 (-)
DBA/2J MGP_DBA2J_G0020956
protein coding gene Chr14:23847180-23936347 (-)
FVB/NJ MGP_FVBNJ_G0020940
protein coding gene Chr14:23800639-23889906 (-)
LP/J MGP_LPJ_G0021025
protein coding gene Chr14:25068235-25159685 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020966
protein coding gene Chr14:25944662-26051856 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021549
protein coding gene Chr14:24701849-24793257 (-)
PWK/PhJ MGP_PWKPhJ_G0020140
protein coding gene Chr14:23305458-23401825 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019964
protein coding gene Chr14:24315870-24410131 (-)
WSB/EiJ MGP_WSBEiJ_G0020447
protein coding gene Chr14:24766021-24861340 (-)



Homology
more
  • Human Ortholog
    HACL1, 2-hydroxyacyl-CoA lyase 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    HACL1, 2-hydroxyacyl-CoA lyase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    2-HPCL, HPCL, HPCL2, PHYH2
  • Links
    NCBI Gene ID: 26061
    neXtProt AC: NX_Q9UJ83
    UniProt: Q9UJ83

  • Chr Location
    3p25.1; chr3:15560704-15601852 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56794 NCBI Gene Model | MGI Sequence Detail 33740 C57BL/6J ±  kb
    transcript NM_019975 RefSeq | MGI Sequence Detail 2618 C57BL/6  
    polypeptide Q9QXE0 UniProt | EBI | MGI Sequence Detail 581 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000008431 2-hydroxyacyl-CoA lyase 1
    • EC
    • InterPro Domains
      IPR029035 DHS-like NAD/FAD-binding domain superfamily
      IPR029061 Thiamin diphosphate-binding fold
      IPR012000 Thiamine pyrophosphate enzyme, central domain
      IPR011766 Thiamine pyrophosphate enzyme, C-terminal TPP-binding
      IPR012001 Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain
    Molecular
    Reagents
    less
    • All nucleic 54
      cDNA 54

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1919263
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 4
      Gene Ontology 7
      Phenotypes 6
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory