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Rec8 Gene Detail
Summary
  • Symbol
    Rec8
  • Name
    REC8 meiotic recombination protein
  • Synonyms
    mrec, Rec8L1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929645
    NCBI Gene: 56739
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:55855494-55862852 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 14, 28.19 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    28 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929645
protein coding gene Chr14:55855459-55862852 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021356
protein coding gene Chr14:49659158-49666475 (+)
A/J MGP_AJ_G0021315
protein coding gene Chr14:48666930-48674239 (+)
AKR/J MGP_AKRJ_G0021291
protein coding gene Chr14:50412764-50420109 (+)
BALB/cJ MGP_BALBcJ_G0021319
protein coding gene Chr14:48619614-48634207 (+)
C3H/HeJ MGP_C3HHeJ_G0021099
protein coding gene Chr14:50098088-50106360 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021757
protein coding gene Chr14:52149395-52156702 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019304
protein coding gene Chr14:47041194-47048321 (+)
CAST/EiJ MGP_CASTEiJ_G0020618
protein coding gene Chr14:46361715-46370758 (+)
CBA/J MGP_CBAJ_G0021066
protein coding gene Chr14:53710685-53717986 (+)
DBA/2J MGP_DBA2J_G0021187
protein coding gene Chr14:48391044-48398393 (+)
FVB/NJ MGP_FVBNJ_G0021169
protein coding gene Chr14:47839297-47846619 (+)
LP/J MGP_LPJ_G0021261
protein coding gene Chr14:50703779-50713154 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021193
protein coding gene Chr14:53069358-53076668 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021784
protein coding gene Chr14:49599738-49607444 (+)
PWK/PhJ MGP_PWKPhJ_G0020365
protein coding gene Chr14:44923108-44930534 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020193
protein coding gene Chr14:45604951-45615783 (+)
WSB/EiJ MGP_WSBEiJ_G0020671
protein coding gene Chr14:49886728-49894137 (+)



Homology
more
  • Human Ortholog
    REC8, REC8 meiotic recombination protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    REC8, REC8 meiotic recombination protein
  • Synonyms
    HR21spB, REC8L1, Rec8p
  • Links
    NCBI Gene ID: 9985
    neXtProt AC: NX_O95072
    UniProt: O95072

  • Chr Location
    14q12; chr14:24171853-24180923 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 4 alleles in 6 genetic backgrounds
    4 phenotypes from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are infertile and exhibit small ovaries and testes. Females show absence of ovarian follicles and abnormal meiosis, while males exhibit abnormal chromosome pairing during meiosis, abnormal synaptonemal complex formation, and arrest of male meiosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000002324 Ensembl Gene Model | MGI Sequence Detail 7359 C57BL/6J ±  kb
    transcript ENSMUST00000002395 Ensembl | MGI Sequence Detail 2184 Not Applicable  
    polypeptide ENSMUSP00000002395 Ensembl | MGI Sequence Detail 591 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 19
      Primer pair 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2145829
    References
    more
    • Summaries
      All 109
      Developmental Gene Expression 39
      Gene Ontology 17
      Phenotypes 33
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:343800 Souali-Crespo S, et al., Loss of NR5A1 in mouse Sertoli cells after sex determination changes cellular identity and induces cell death by anoikis. Development. 2023 Dec 15;150(24)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory