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Rec8 Gene Detail
Summary
  • Symbol
    Rec8
  • Name
    REC8 meiotic recombination protein
  • Synonyms
    mrec, Rec8L1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929645
    NCBI Gene: 56739
  • Gene Overview
    MyGene.info: REC8
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:55618037-55625395 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 28.19 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    28 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929645
protein coding gene Chr14:55617995-55625395 (.)
129S1/SvImJ MGP_129S1SvImJ_G0021356
protein coding gene Chr14:49659158-49666475 (+)
A/J MGP_AJ_G0021315
protein coding gene Chr14:48666930-48674239 (+)
AKR/J MGP_AKRJ_G0021291
protein coding gene Chr14:50412764-50420109 (+)
BALB/cJ MGP_BALBcJ_G0021319
protein coding gene Chr14:48619614-48634207 (+)
C3H/HeJ MGP_C3HHeJ_G0021099
protein coding gene Chr14:50098088-50106360 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021757
protein coding gene Chr14:52149395-52156702 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019304
protein coding gene Chr14:47041194-47048321 (+)
CAST/EiJ MGP_CASTEiJ_G0020618
protein coding gene Chr14:46361715-46370758 (+)
CBA/J MGP_CBAJ_G0021066
protein coding gene Chr14:53710685-53717986 (+)
DBA/2J MGP_DBA2J_G0021187
protein coding gene Chr14:48391044-48398393 (+)
FVB/NJ MGP_FVBNJ_G0021169
protein coding gene Chr14:47839297-47846619 (+)
LP/J MGP_LPJ_G0021261
protein coding gene Chr14:50703779-50713154 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021193
protein coding gene Chr14:53069358-53076668 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021784
protein coding gene Chr14:49599738-49607444 (+)
PWK/PhJ MGP_PWKPhJ_G0020365
protein coding gene Chr14:44923108-44930534 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020193
protein coding gene Chr14:45604951-45615783 (+)
WSB/EiJ MGP_WSBEiJ_G0020671
protein coding gene Chr14:49886728-49894137 (+)



Homology
more
  • Human Ortholog
    REC8, REC8 meiotic recombination protein
  • Vertebrate Orthologs
    8
  • Human Ortholog
    REC8, REC8 meiotic recombination protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HR21spB, REC8L1, Rec8p
  • Links
    NCBI Gene ID: 9985
    neXtProt AC: NX_O95072
    UniProt: O95072

  • Chr Location
    14q12; chr14:24171853-24180408 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 3 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice are infertile and exhibit small ovaries and testes. Females show absence of ovarian follicles and abnormal meiosis, while males exhibit abnormal chromosome pairing during meiosis, abnormal synaptonemal complex formation, and arrest of male meiosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000002324 Ensembl Gene Model | MGI Sequence Detail 7359 C57BL/6J ±  kb
    transcript ENSMUST00000002395 Ensembl | MGI Sequence Detail 2184 Not Applicable  
    polypeptide ENSMUSP00000002395 Ensembl | MGI Sequence Detail 591 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 18
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2145829
    References
    more
    • Summaries
      All 84
      Developmental Gene Expression 27
      Gene Ontology 16
      Phenotypes 23
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:263202 Ungewitter EK, et al., Loss of Glis3 causes dysregulation of retrotransposon silencing and germ cell demise in fetal mouse testis. Sci Rep. 2018 Jun 25;8(1):9662

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory