Cyp2d22 MGI Mouse Gene Detail - MGI:1929474 - cytochrome P450, family 2, subfamily d, polypeptide 22

Symbol

Cyp2d22
Name

cytochrome P450, family 2, subfamily d, polypeptide 22
Synonyms

2D22

Feature Type

protein coding gene
IDs

MGI:1929474
NCBI Gene: 56448
Member of

Cyp2d cluster
Alliance

genome feature page
Transcription Start Sites

4 TSS

Sequence Map

Chr15:82254728-82264461 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 38.57 cM, cytoband E2
Mapping Data

2 experiments

SNPs within 2kb

331 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1929474	protein coding gene	Chr15:82254728-82264461 (-)
129S1/SvImJ	ENSMUSG00200052415	protein coding gene	Chr15:79368371-79378139 (-)
A/J	ENSMUSG00195044578	protein coding gene	Chr15:79300024-79309803 (-)
AKR/J	ENSMUSG00220050622	protein coding gene	Chr15:79343182-79352967 (-)
BALB/cJ	ENSMUSG00180052622	protein coding gene	Chr15:79176967-79186743 (-)
C3H/HeJ	ENSMUSG00175045085	protein coding gene	Chr15:79487926-79497702 (-)
C57BL/6NJ	ENSMUSG00215048793	protein coding gene	Chr15:79272310-79282039 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020084	protein coding gene	Chr15:76373493-76381739 (-)
CAST/EiJ	ENSTCUG00005045716	protein coding gene	Chr15:78789598-78799308 (-)
CBA/J	ENSMUSG00210048520	protein coding gene	Chr15:79263026-79272804 (-)
DBA/2J	ENSMUSG00185045692	protein coding gene	Chr15:79286916-79296656 (-)
FVB/NJ	ENSMUSG00205039622	protein coding gene	Chr15:79023475-79033187 (-)
JF1/MsJ	ENSUMUG00000032412	protein coding gene	Chr15:78862559-78872307 (-)
LP/J	ENSMUSG00230039494	protein coding gene	Chr15:82608752-82618516 (-)
NOD/ShiLtJ	ENSMUSG00190031950	protein coding gene	Chr15:79280127-79289903 (-)
NZO/HlLtJ	ENSMUSG00225047352	protein coding gene	Chr15:82947305-82957071 (-)
PWK/PhJ	ENSLUMG00010046686	protein coding gene	Chr15:79073568-79083260 (-)
SPRET/EiJ	ENSMSPG00010043353	protein coding gene	Chr15:80719186-80729296 (-)
WSB/EiJ	ENSIUOG00005041644	protein coding gene	Chr15:79365015-79374771 (-)

Human Ortholog

CYP2D6, cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene)

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CYP2D6, cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene)
Synonyms

CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450C2D, P450-DB1, P450DB1
Links

HGNC:2625

NCBI Gene ID: 1565

UniProt: P10635
Chr Location

22q13.2; chr22:42125962-42131236 (-) GRCh38

Human Ortholog

CYP2D7, cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)
Synonyms

CYP2D, CYP2D@, CYP2D7AP, CYP2D7P, CYP2D7P1, P450C2D, P450DB1, RNA40057
Links

HGNC:2624

NCBI Gene ID: 1564

UniProt: A0A087X1C5
Chr Location

22q13.2; chr22:42139576-42149455 (-) GRCh38

MGI Vertebrate Homology

Cyp2d22 stringent orthology
2 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CYP2D6, CYP2D7
Gene Tree

Cyp2d22

Diseases

9 with human CYP2D6 associations

				Human Disease	Mouse Models
				acute lymphoblastic leukemia IDs acute lymphoblastic leukemia DOID:9952 EFO:0000220 ICD10CM:C91.00 ICD9CM:204.0 NCI:C3167 NCI:C7055 OMIM:247640 OMIM:613065 ORDO:513 UMLS_CUI:C0023449 UMLS_CUI:C1335469
				acute myeloid leukemia IDs acute myeloid leukemia DOID:9119 DOID:9118 DOID:9171 ICD10CM:C92.0 ICD9CM:205.0 KEGG:05221 MESH:D015470 NCI:C3171 OMIM:601626 UMLS_CUI:C0023467
				asthma IDs asthma DOID:2841 DOID:12703 DOID:13829 DOID:13830 DOID:2840 DOID:5783 ICD10CM:J45 ICD9CM:493 ICD9CM:493.9 KEGG:05310 MESH:D001249 NCI:C28397 OMIM:600807 UMLS_CUI:C0004096
				autoimmune hepatitis IDs autoimmune hepatitis DOID:2048 DOID:4745 ICD9CM:571.42 MESH:D019693 NCI:C27778 UMLS_CUI:C0241910 UMLS_CUI:C1332355
				extrapyramidal and movement disease IDs extrapyramidal and movement disease DOID:13839 ICD10CM:G25.9 ICD9CM:333.90 UMLS_CUI:C0477355
				head and neck squamous cell carcinoma IDs head and neck squamous cell carcinoma DOID:5520 MESH:D000077195 NCI:C34447 OMIM:275355 UMLS_CUI:C1168401
				major depressive disorder IDs major depressive disorder DOID:1470 DOID:10614 DOID:2240 DOID:2241 DOID:7580 ICD10CM:F32 ICD10CM:F33.9 ICD9CM:296.2 ICD9CM:296.20 ICD9CM:296.3 ICD9CM:296.30 NCI:C195908 NCI:C34796 OMIM:608516 OMIM:608520 OMIM:608691 UMLS_CUI:C0024517 UMLS_CUI:C0154409
				opiate dependence IDs opiate dependence DOID:2559 ICD10CM:F11.2 ICD9CM_2006:304.0 ICD9CM:304.0 ICD9CM:304.00 NCI:C205836 UMLS_CUI:C0524662
				rhinitis IDs rhinitis DOID:4483 MESH:D012220 NCI:C34986 UMLS_CUI:C0035455

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
33 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

5
Radiation induced

2
Targeted

6
Genomic Mutations

7 involving Cyp2d22
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

36 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

32
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

703
Tissues

106
cDNA Data

97
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

47
RefSeq

4
UniProt

4
CCDS

CCDS37159.1

Ensembl

ENSMUSG00000061740 (Evidence)
NCBI Gene

56448

			Length	Strain/Species	Flank
genomic	56448	NCBI Gene Model \| MGI Sequence Detail	9734	C57BL/6J	± kb
transcript	NM_001163472	RefSeq \| MGI Sequence Detail	2788	C57BL/6
polypeptide	NP_062797	RefSeq \| MGI Sequence Detail	500	C57BL/6

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UniProt

4 Sequences
EC

1.14.14.-
InterPro Domains

IPR001128 Cytochrome P450

IPR002397 Cytochrome P450, B-class

IPR017972 Cytochrome P450, conserved site

IPR002401 Cytochrome P450, E-class, group I

IPR008069 Cytochrome P450, E-class, group I, CYP2D-like

IPR050182 Cytochrome P450 family 2

IPR036396 Cytochrome P450 superfamily

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All nucleic 100

cDNA 98

Primer pair 2

Microarray probesets 4

Summaries

All 61

Developmental Gene Expression 3

Diseases 1

Gene Ontology 8

Phenotypes 33
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)

TSS for Cyp2d22:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr135553	Chr15:82264473-82264482 (-)	-17 bp
Tssr135552	Chr15:82264380-82264464 (-)	39 bp
Tssr135551	Chr15:82264341-82264351 (-)	115 bp
Tssr135550	Chr15:82256137-82256162 (-)	8,311 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/15/2026 MGI 6.29