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Asic5 Gene Detail
Summary
  • Symbol
    Asic5
  • Name
    acid-sensing (proton-gated) ion channel family member 5
  • Synonyms
    Accn5, BLINaC, brain-liver-intestine amiloride-sensitive sodium channel
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929259
    NCBI Gene: 58170
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr3:81982293-82021233 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 35.97 cM, cytoband E-F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    397 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929259
protein coding gene Chr3:81982290-82021233 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027324
protein coding gene Chr3:81777660-81816806 (+)
A/J MGP_AJ_G0027286
protein coding gene Chr3:79070186-79108996 (+)
AKR/J MGP_AKRJ_G0027254
protein coding gene Chr3:80938960-80977571 (+)
BALB/cJ MGP_BALBcJ_G0027297
protein coding gene Chr3:79171009-79209407 (+)
C3H/HeJ MGP_C3HHeJ_G0027041
protein coding gene Chr3:81228624-81267638 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027743
protein coding gene Chr3:84883624-84922881 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025096
protein coding gene Chr3:74837125-74876206 (+)
CAST/EiJ MGP_CASTEiJ_G0026488
protein coding gene Chr3:81398871-81441493 (+)
CBA/J MGP_CBAJ_G0027016
protein coding gene Chr3:87724723-87766037 (+)
DBA/2J MGP_DBA2J_G0027152
protein coding gene Chr3:78631733-78670509 (+)
FVB/NJ MGP_FVBNJ_G0027120
protein coding gene Chr3:76916282-76957610 (+)
LP/J MGP_LPJ_G0027260
protein coding gene Chr3:82776664-82818798 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027139
protein coding gene Chr3:94104982-94147570 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027801
protein coding gene Chr3:80742162-80781008 (+)
PWK/PhJ MGP_PWKPhJ_G0026222
protein coding gene Chr3:78360591-78401166 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026038
protein coding gene Chr3:79957124-79996895 (+)
WSB/EiJ MGP_WSBEiJ_G0026566
protein coding gene Chr3:81084865-81127375 (+)



Homology
more
  • Human Ortholog
    ASIC5, acid sensing ion channel subunit family member 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ASIC5, acid sensing ion channel subunit family member 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ACCN5, HINAC, INAC
  • Links
    NCBI Gene ID: 51802
    neXtProt AC: NX_Q9NY37
    UniProt: Q9NY37

  • Chr Location
    4q32.1; chr4:155829699-155867303 (-)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 58170 NCBI Gene Model | MGI Sequence Detail 38941 C57BL/6J ±  kb
transcript NM_021370 RefSeq | MGI Sequence Detail 1657 C57BL/6  
polypeptide Q9R0Y1 UniProt | EBI | MGI Sequence Detail 495 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 4
    Genomic 1
    cDNA 3

    Microarray probesets 3
References
more
  • Summaries
    All 29
    Diseases 1
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:66332 Sakai H, et al., Cloning and functional expression of a novel degenerin-like Na+ channel gene in mammals. J Physiol. 1999 Sep 1;519 Pt 2:323-33
  • Latest
    J:215064 Boiko N, et al., Restrictive expression of acid-sensing ion channel 5 (asic5) in unipolar brush cells of the vestibulocerebellum. PLoS One. 2014;9(3):e91326

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory