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Cldn18 Gene Detail
Summary
  • Symbol
    Cldn18
  • Name
    claudin 18
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929209
    NCBI Gene: 56492
  • Gene Overview
    MyGene.info: CLDN18
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:99689461-99717267 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      27807 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 52.00 cM, cytoband E3-F1
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    CLDN18, claudin 18
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CLDN18, claudin 18
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SFTA5, SFTPJ
  • Links
    NCBI Gene ID: 51208
    neXtProt AC: NX_P56856
    UniProt: P56856

  • Chr Location
    3q22.3; chr3:137998816-138033652 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 9489
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CLDN18
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased bone resorption and osteoclast differentiation. Homozygotes for another knock-out allele have impiared alveolarization and alveolar epithelial barrier function.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000028913 VEGA Gene Model | MGI Sequence Detail 27807 C57BL/6J ±  kb
    transcript OTTMUST00000071651 VEGA | MGI Sequence Detail 1750 Not Applicable  
    polypeptide OTTMUSP00000036761 VEGA | MGI Sequence Detail 264 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      347 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      Genomic 1
      cDNA 7

      Microarray probesets 3
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 7
      Gene Ontology 3
      Phenotypes 15
    • Earliest
      J:72106 Niimi T, et al., claudin-18, a Novel Downstream Target Gene for the T/EBP/NKX2.1 Homeodomain Transcription Factor, Encodes Lung- and Stomach-Specific Isoforms through Alternative Splicing. Mol Cell Biol. 2001 Nov;21(21):7380-90
    • Latest
      J:260802 Zhou B, et al., Claudin-18-mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis. J Clin Invest. 2018 Mar 1;128(3):970-984

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory