Automated description from the Alliance of Genome Resources (Release 7.1.0)
Predicted to enable structural molecule activity. Involved in several processes, including cellular response to estrogen stimulus; lung alveolus development; and tight junction assembly. Acts upstream of or within several processes, including negative regulation of bone resorption; negative regulation of osteoclast development; and negative regulation of tumor necrosis factor-mediated signaling pathway. Located in plasma membrane and tight junction. Is expressed in several structures, including gonadal fat pad; gut; male reproductive gland or organ; respiratory system; and skin. Orthologous to human CLDN18 (claudin 18).