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Vapb
Gene Detail
Symbol

Name
ID
Vapb
vesicle-associated membrane protein, associated protein B and C
MGI:1928744
Synonyms
D2Abb2e, VAMP-associated protein 33b, VAP33b
Feature Type
protein coding gene
Genetic Map
Chromosome 2
97.37 cM, cytoband H3
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr2:173737511-173784336 bp, + strand
From VEGA annotation of GRCm38

  46826 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:36163  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: VAMP-associated protein
Gene Tree: Vapb

Human
homologs
Human Homolog VAPB, VAMP (vesicle-associated membrane protein)-associated protein B and C
NCBI Gene ID 9217
neXtProt AC  NX_O95292
Human Synonyms  ALS8, VAMP-B, VAP-B
Human Chr (Location)  20q13.33; chr20:58389119-58451101 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human VAPB
Mutations,
alleles, and
phenotypes
All mutations/alleles(39) : Gene trapped(35) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice exhibited enhanced motor coordination during inverted screen testing. Mice homozygous for another knock-out allele exhibit hypotonia, impaired coordination in older mice and mild tremors.
 
Interactions
Vapb interacts with 437 markers (Mir7b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
Data Summary: Results (7)    Tissues (1)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 7
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) Genomic(1) cDNA(17) Primer pair(1)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000016375 (Evidence)
Ensembl Gene ModelENSMUSG00000054455 (Evidence)
Entrez Gene56491 (Evidence)
DFCITC1751495, TC1702153, TC1576620, TC1597386, TC1650646
DoTSDT.40168458, DT.482254, DT.492183, DT.94278763, DT.94224315
NIA Mouse Gene IndexU002918
Consensus CDS ProjectCCDS17146.1
International Mouse Knockout Project StatusVapb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016375 VEGA Gene Model | MGI Sequence Detail 46826 C57BL/6J ±  kb
transcript OTTMUST00000039412 VEGA | MGI Sequence Detail 7029 Not Applicable 
polypeptide OTTMUSP00000017608 VEGA | MGI Sequence Detail 243 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(2) UniProt(9)
Polymorphisms
SNPs within 2kb(123 from dbSNP Build 137)    SNPs within 2kb including multiple locations(131)
Protein-related
information
ResourceIDDescription
InterPro IPR000535 Major sperm protein
InterPro IPR008962 PapD-like
InterPro IPR016763 Vesicle-associated membrane protein
Protein Ontology PR:000029849 vesicle-associated membrane protein-associated protein B/C
References
(Earliest) J:34960 Chambers DM, et al., Isolation and mapping of novel mouse brain cDNA clones containing trinucleotide repeats, and demonstration of novel alleles in recombinant inbred strains. Genome Res. 1996 Aug;6(8):715-23
(Latest) J:198500 Nakahara M, et al., Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Mamm Genome. 2013 Jun;24(5-6):228-39
All references(48)
Other
accession IDs
MGD-MRK-34262, MGI:106568, MGI:2138863, MGI:2139066, MGI:2139072, MGI:2139546

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory