Vapb
Gene Detail

Symbol Name ID

Vapb vesicle-associated membrane protein, associated protein B and C MGI:1928744

Synonyms

D2Abb2e, VAMP-associated protein 33b, VAP33b

Feature Type

protein coding gene

Genetic Map

Chromosome 2

97.37 cM, cytoband H3
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr2:173737511-173784336 bp, + strand From VEGA annotation of GRCm38   46826 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:36163  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: VAMP-associated protein
Gene Tree: Vapb

Human homologs

Human Homolog		VAPB, VAMP (vesicle-associated membrane protein)-associated protein B and C
NCBI Gene ID		9217
neXtProt AC		NX_O95292
Human Synonyms		ALS8, VAMP-B, VAP-B
Human Chr (Location)		20q13.33; chr20:56964175-57026157 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human VAPB

Alleles and phenotypes

All alleles(37) : Targeted(2) Gene trapped(35)

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	activation of signaling protein activity involved in unfolded protein response, cellular calcium ion homeostasis, ...
Component	endoplasmic reticulum, endoplasmic reticulum membrane, ...
Function	beta-tubulin binding, enzyme binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (7)    Tissues (1)    Images (7)
Theiler Stages: 23

Assay Type	Results
RNA in situ	7

cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(19) Genomic(1) cDNA(17) Primer pair(1)
Microarray probesets(8)

Other database links

VEGA Gene Model	OTTMUSG00000016375 (Evidence)
Ensembl Gene Model	ENSMUSG00000054455 (Evidence)
Entrez Gene	56491 (Evidence)
DFCI	TC1576620, TC1597386, TC1650646, TC1702153, TC1751495
DoTS	DT.40168458, DT.482254, DT.492183, DT.94224315, DT.94278763
NIA Mouse Gene Index	U002918
Consensus CDS Project	CCDS17146.1
International Mouse Knockout Project Status	Vapb

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016375	VEGA Gene Model | MGI Sequence Detail	46826	C57BL/6J
transcript	OTTMUST00000039412	VEGA | MGI Sequence Detail	7029	Not Applicable
polypeptide	OTTMUSP00000017608	VEGA | MGI Sequence Detail	243	Not Applicable

All sequences(57) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(100 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000535	Major sperm protein
InterPro	IPR008962	PapD-like
InterPro	IPR016763	Vesicle-associated membrane protein
Protein Ontology	PR:000029849	vesicle-associated membrane protein-associated protein B/C

References

(Earliest) J:34960 Chambers DM, et al., Isolation and mapping of novel mouse brain cDNA clones containing trinucleotide repeats, and demonstration of novel alleles in recombinant inbred strains. Genome Res. 1996 Aug;6(8):715-23
(Latest) J:179896 Choi SW, et al., VapB as a regulator of osteoclastogenesis via modulation of PLCgamma2-Ca(2+)-NFAT signaling. FEBS Lett. 2012 Feb 3;586(3):263-9
All references(46)

Other accession IDs

MGD-MRK-34262, MGI:106568, MGI:2138863, MGI:2139066, MGI:2139072, MGI:2139546