Symbol Name ID |
Vapb
vesicle-associated membrane protein, associated protein B and C MGI:1928744 |
Darker colors indicate more annotations |
Human Phenotypes | Calf muscle hypertrophy |
Foot dorsiflexor weakness |
Lower limb muscle weakness |
Upper limb muscle weakness |
Spasticity |
EMG: neuropathic changes |
Difficulty climbing stairs |
Muscle spasm |
Distal muscle weakness |
Fatigable weakness of bulbar muscles |
Fatigable weakness of swallowing muscles |
Fatigable weakness of respiratory muscles |
Generalized muscle weakness |
Progressive muscle weakness |
Proximal muscle weakness |
Gowers sign |
Myotonia |
Skeletal muscle atrophy |
Distal amyotrophy |
Progressive distal muscular atrophy |
Proximal amyotrophy |
Spinal muscular atrophy |
Progressive spinal muscular atrophy |
Disease(s) Associated with VAPB | |||||||||||||||||||||||
amyotrophic lateral sclerosis | |||||||||||||||||||||||
amyotrophic lateral sclerosis type 8 | |||||||||||||||||||||||
autosomal dominant adult-onset proximal spinal muscular atrophy |
Mouse Phenotypes | skeletal muscle fiber atrophy |
centrally nucleated skeletal muscle fibers |
hypotonia |
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Availability | Mouse Genotype | |||
Vapbtm1.1Tsud/Vapbtm1.1Tsud | ||||
Vapbtm1.2Ics/Vapbtm1.2Ics |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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