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Htra2 Gene Detail
Summary
  • Symbol
    Htra2
  • Name
    HtrA serine peptidase 2
  • Synonyms
    HtrA2, mnd2, OMI, Prss25
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928676
    NCBI Gene: 64704
  • Gene Overview
    MyGene.info: HTRA2
Location & Maps
more
  • Sequence Map
    Chr6:83051266-83055273 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4008 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 35.94 cM
  • Mapping Data
    11 experiments
Homology
more
  • Human Ortholog
    HTRA2, HtrA serine peptidase 2
  • Vertebrate Orthologs
    28
  • Human Ortholog
    HTRA2, HtrA serine peptidase 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    OMI, PARK13, PRSS25
  • Links
    NCBI Gene ID: 27429
    neXtProt AC: NX_O43464

  • Chr Location
    2p12; chr2:74529405-74533556 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Htra2 mouse models; 1 with human HTRA2 associations

Human Disease Mouse Models
       Parkinson Disease 13, Autosomal Dominant, Susceptibility To; PARK13   OMIM: 610297 View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    67 phenotypes from 4 alleles in 6 genetic backgrounds
    4 phenotypes from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Gene trapped
    3
  • Spontaneous
    2
  • Targeted
    5
  • Genomic Mutations
    1 involving Htra2
  • Incidental Mutations
    APF , CvDC
Homozygous mutations of this gene cause progressive parkinsonian symptoms, loss of striatal neurons, spleen and thymus atrophy, failure to thrive, and death before 40 days of age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022486 VEGA Gene Model | MGI Sequence Detail 4008 C57BL/6J ±  kb
transcript OTTMUST00000053814 VEGA | MGI Sequence Detail 1725 Not Applicable  
polypeptide OTTMUSP00000025609 VEGA | MGI Sequence Detail 458 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    57 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
less
  • All nucleic 8
    Genomic 1
    cDNA 7

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-12335, MGI:2141430, MGI:97039
References
more
  • Summaries
    All 73
    Diseases 3
    Gene Ontology 12
    Phenotypes 29
  • Earliest
    J:12780 Jones JM, et al., mnd2: a new mouse model of inherited motor neuron disease. Genomics. 1993 Jun;16(3):669-77
  • Latest
    J:229160 Casadei N, et al., Mitochondrial defects and neurodegeneration in mice overexpressing wild-type or G399S mutant HtrA2. Hum Mol Genet. 2016 Feb 1;25(3):459-71

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory