About   Help   FAQ
Htra2
Gene Detail
Symbol

Name
ID
Htra2
HtrA serine peptidase 2
MGI:1928676
Synonyms
HtrA2, mnd2, OMI, Prss25
Feature Type
protein coding gene
Genetic Map
Chromosome 6
35.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr6:83051266-83055273 bp, - strand
From VEGA annotation of GRCm38

  4008 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:113300  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 20 zebrafish

HCOP human homology predictions: HTRA2
Protein SuperFamily: serine protease, HTRA type
Gene Tree: Htra2

Human
homologs
HTRA2, HtrA serine peptidase 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 27429
neXtProt AC: NX_O43464

Human Synonyms: OMI, PARK13, PRSS25

Human Chr (Location): 2p12; chr2:74529405-74533556 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human HTRA2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(3) Spontaneous(2) Targeted(2)
Genomic Mutations involving Htra2 (1)
Incidental mutations (data from APF , CvDC )
 
Homozygotes for a spontaneous null mutation exhibit progressive neurological symptoms including involuntary movements, akinesis, and abnormal posture beginning at 20 days of age, striatal neurodegeneration, and lethality between 30-40 days of age.
 
Human Diseases Modeled in Mice Using Htra2 (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Htra2 interacts with 28 markers (Mir22, Mir124a-1, Mir124a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (45 annotations)
Process adult locomotory behavior, adult walking behavior, ...
Component CD40 receptor complex, chromatin, ...
Function hydrolase activity, peptidase activity, ...
External Resources: FuncBase
Expression
cDNA source data(6)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase htra2    NEW 
Molecular
reagents
All nucleic(8) Genomic(1) cDNA(7)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000022486 (Evidence)
Ensembl Gene Model ENSMUSG00000068329 (Evidence)
Entrez Gene 64704 (Evidence)
NIA Mouse Gene Index U082650
EC 3.4.21.108
Consensus CDS Project CCDS20267.1
International Mouse Phenotyping Consortium Status Htra2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022486 VEGA Gene Model | MGI Sequence Detail 4008 C57BL/6J ±  kb
transcript OTTMUST00000053814 VEGA | MGI Sequence Detail 1725 Not Applicable 
polypeptide OTTMUSP00000025609 VEGA | MGI Sequence Detail 458 Not Applicable 

For the selected sequences
All sequences(69) RefSeq(2) UniProt(10)
Polymorphisms
RFLP(1) : SNPs within 2kb(64 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001478 PDZ domain
InterPro IPR001940 Peptidase S1C
InterPro IPR009003 Peptidase S1, PA clan
InterPro IPR001254 Serine proteases, trypsin domain
Protein Ontology PR:000008839 serine protease HTRA2, mitochondrial
References
(Earliest) J:12780 Jones JM, et al., mnd2: a new mouse model of inherited motor neuron disease. Genomics. 1993 Jun;16(3):669-77
(Latest) J:217559 Goo HG, et al., HtrA2/Omi influences the stability of LON protease 1 and prohibitin, proteins involved in mitochondrial homeostasis. Exp Cell Res. 2014 Nov 1;328(2):456-65
All references(70)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-12335, MGI:2141430, MGI:97039

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory