About   Help   FAQ
Htra2
Gene Detail
Symbol

Name
ID
Htra2
HtrA serine peptidase 2
MGI:1928676
Synonyms
HtrA2, mnd2, OMI, Prss25
Feature Type
protein coding gene
Genetic Map
Chromosome 6
35.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr6:83051266-83055273 bp, - strand
From VEGA annotation of GRCm38

  4008 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:113300  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 20 zebrafish

Protein SuperFamily: serine protease, HTRA type
Gene Tree: Htra2

Human
homologs
Human Homolog HTRA2, HtrA serine peptidase 2
NCBI Gene ID 27429
neXtProt AC  NX_O43464
Human Synonyms  OMI, PARK13, PRSS25
Human Chr (Location)  2p12; chr2:74529405-74533556 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human HTRA2
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(3) Spontaneous(1) Targeted(2)
Incidental mutations (data from APF )
 
Homozygotes for a spontaneous null mutation exhibit progressive neurological symptoms including involuntary movements, akinesis, and abnormal posture beginning at 20 days of age, striatal neurodegeneration, and lethality between 30-40 days of age.
 
Human Diseases Modeled Using Mouse Htra2 (1)    Alleles Annotated to Human Diseases(2)   
Interactions
Htra2 interacts with 28 markers (Mir22, Mir124a-1, Mir124a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (45 annotations)
Process adult locomotory behavior, adult walking behavior, ...
Component CD40 receptor complex, chromatin, ...
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) Genomic(1) cDNA(7)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000022486 (Evidence)
Ensembl Gene ModelENSMUSG00000068329 (Evidence)
Entrez Gene64704 (Evidence)
NIA Mouse Gene IndexU082650
EC3.4.21.108
Consensus CDS ProjectCCDS20267.1
International Mouse Knockout Project StatusHtra2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022486 VEGA Gene Model | MGI Sequence Detail 4008 C57BL/6J ±  kb
transcript OTTMUST00000053814 VEGA | MGI Sequence Detail 1725 Not Applicable 
polypeptide OTTMUSP00000025609 VEGA | MGI Sequence Detail 458 Not Applicable 

For the selected sequences
All sequences(76) RefSeq(2) UniProt(19)
Polymorphisms
RFLP(1) : SNPs within 2kb(64 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001478 PDZ domain
InterPro IPR001254 Peptidase S1
InterPro IPR001940 Peptidase S1C
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000008839 serine protease HTRA2, mitochondrial
References
(Earliest) J:12780 Jones JM, et al., mnd2: a new mouse model of inherited motor neuron disease. Genomics. 1993 Jun;16(3):669-77
(Latest) J:214844 Andree M, et al., BID-dependent release of mitochondrial SMAC dampens XIAP-mediated immunity against Shigella. EMBO J. 2014 Jul 23;
All references(71)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-12335, MGI:2141430, MGI:97039

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/09/2014
MGI 5.20
The Jackson Laboratory