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Htra2 Gene Detail
Summary
  • Symbol
    Htra2
  • Name
    HtrA serine peptidase 2
  • Synonyms
    HtrA2, mnd2, OMI, Prss25
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928676
    NCBI Gene: 64704
  • Gene Overview
    MyGene.info: HTRA2
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:83051266-83054571 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 35.94 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    54 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928676
protein coding gene Chr6:83051266-83055273 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030911
protein coding gene Chr6:84054950-84058956 (-)
A/J MGP_AJ_G0030880
protein coding gene Chr6:80841615-80845622 (-)
AKR/J MGP_AKRJ_G0030808
protein coding gene Chr6:83171073-83175077 (-)
BALB/cJ MGP_BALBcJ_G0030890
protein coding gene Chr6:80854573-80858577 (-)
C3H/HeJ MGP_C3HHeJ_G0030820
protein coding gene Chr6:101208579-101212572 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031350
protein coding gene Chr6:86334317-86338323 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028536
protein coding gene Chr6:79200363-79204295 (-)
CAST/EiJ MGP_CASTEiJ_G0029999
protein coding gene Chr6:83169624-83175162 (-)
CBA/J MGP_CBAJ_G0030577
protein coding gene Chr6:89746589-89750596 (-)
DBA/2J MGP_DBA2J_G0030730
protein coding gene Chr6:80161224-80165231 (-)
FVB/NJ MGP_FVBNJ_G0030683
protein coding gene Chr6:79368941-79372948 (-)
LP/J MGP_LPJ_G0030809
protein coding gene Chr6:84048848-84052856 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030719
protein coding gene Chr6:94051348-94055354 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031374
protein coding gene Chr6:82983815-82987832 (-)
PWK/PhJ MGP_PWKPhJ_G0029714
protein coding gene Chr6:79053416-79057432 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029542
protein coding gene Chr6:81827589-81834332 (-)
WSB/EiJ MGP_WSBEiJ_G0030080
protein coding gene Chr6:83423392-83427413 (-)



Homology
more
  • Human Ortholog
    HTRA2, HtrA serine peptidase 2
  • Vertebrate Orthologs
    28
  • Human Ortholog
    HTRA2, HtrA serine peptidase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MGCA8, OMI, PARK13, PRSS25
  • Links
    NCBI Gene ID: 27429
    neXtProt AC: NX_O43464
    UniProt: O43464

  • Chr Location
    2p13.1; chr2:74529405-74533556 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human HTRA2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    67 phenotypes from 4 alleles in 6 genetic backgrounds
    12 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutations of this gene cause progressive parkinsonian symptoms, loss of striatal neurons, spleen and thymus atrophy, failure to thrive, and death before 40 days of age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 64704 NCBI Gene Model | MGI Sequence Detail 3306 C57BL/6J ±  kb
    transcript NM_019752 RefSeq | MGI Sequence Detail 1739 C57BL/6  
    polypeptide Q9JIY5 UniProt | EBI | MGI Sequence Detail 458 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      Genomic 1
      cDNA 8

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12335, MGI:2141430, MGI:97039
    References
    more
    • Summaries
      All 84
      Developmental Gene Expression 1
      Gene Ontology 15
      Phenotypes 32
    • Earliest
      J:12780 Jones JM, et al., mnd2: a new mouse model of inherited motor neuron disease. Genomics. 1993 Jun;16(3):669-77
    • Latest
      J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory