Htra2
Gene Detail

Symbol Name ID

Htra2 HtrA serine peptidase 2 MGI:1928676

Synonyms

HtrA2, mnd2, OMI, Prss25

Feature Type

protein coding gene

Genetic Map

Chromosome 6

35.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)

Sequence Map

Chr6:83051266-83055273 bp, - strand From VEGA annotation of GRCm38   4008 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:113300  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 20 zebrafish

Protein SuperFamily: serine protease, HTRA type
Gene Tree: Htra2

Human homologs

Human Homolog		HTRA2, HtrA serine peptidase 2
NCBI Gene ID		27429
neXtProt AC		NX_O43464
Human Synonyms		OMI, PARK13, PRSS25
Human Chr (Location)		2p12; chr2:74756532-74760683 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human HTRA2

Alleles and phenotypes

All alleles(6) : Targeted(2) Gene trapped(3) Spontaneous(1)
 

Homozygotes for a spontaneous null mutation exhibit progressive neurological symptoms including involuntary movements, akinesis, and abnormal posture beginning at 20 days of age, striatal neurodegeneration, and lethality between 30-40 days of age.

 
Human Diseases Modeled Using Mouse Htra2 (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (35 annotations)

Process	adult locomotory behavior, adult walking behavior, ...
Component	CD40 receptor complex, cytosol, ...
Function	catalytic activity, hydrolase activity, ...

External Resources: FuncBase

Expression

cDNA source data(6)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(8) Genomic(1) cDNA(7)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000022486 (Evidence)
Ensembl Gene Model	ENSMUSG00000068329 (Evidence)
Entrez Gene	64704 (Evidence)
NIA Mouse Gene Index	U082650
EC	3.4.21.108
Consensus CDS Project	CCDS20267.1
International Mouse Knockout Project Status	Htra2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022486	VEGA Gene Model | MGI Sequence Detail	4008	C57BL/6J
transcript	OTTMUST00000053814	VEGA | MGI Sequence Detail	1725	Not Applicable
polypeptide	OTTMUSP00000025609	VEGA | MGI Sequence Detail	458	Not Applicable

All sequences(61) RefSeq(2) UniProt(8)

Polymorphisms

RFLP(1) : SNPs(44 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001478	PDZ domain
InterPro	IPR001940	Peptidase S1C
InterPro	IPR009003	Trypsin-like cysteine/serine peptidase domain
Protein Ontology	PR:000008839	serine protease HTRA2, mitochondrial

References

(Earliest) J:12780 Jones JM, et al., mnd2: a new mouse model of inherited motor neuron disease. Genomics. 1993 Jun;16(3):669-77
(Latest) J:186355 Li B, et al., Omi/HtrA2 is a positive regulator of autophagy that facilitates the degradation of mutant proteins involved in neurodegenerative diseases. Cell Death Differ. 2010 Nov;17(11):1773-84
All references(65)

Other accession IDs

MGD-MRK-12335, MGI:2141430, MGI:97039