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Htra2 Gene Detail
Summary
  • Symbol
    Htra2
  • Name
    HtrA serine peptidase 2
  • Synonyms
    HtrA2, mnd2, OMI, Prss25
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928676
    NCBI Gene: 64704
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:83028247-83031552 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 35.94 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    116 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928676
 protein coding gene Chr6:83028247-83032254 (-)
129S1/SvImJ ENSMUSG00200012125
 protein coding gene Chr6:79997603-80000910 (-)
A/J ENSMUSG00195011833
 protein coding gene Chr6:79674324-79677630 (-)
AKR/J ENSMUSG00220001865
 protein coding gene Chr6:78617763-78621069 (-)
BALB/cJ ENSMUSG00180008891
 protein coding gene Chr6:80050330-80053636 (-)
C3H/HeJ ENSMUSG00175033361
 protein coding gene Chr6:97356381-97359672 (+)
C57BL/6NJ ENSMUSG00215007800
 protein coding gene Chr6:80047838-80051143 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028536
 protein coding gene Chr6:79200363-79204295 (-)
CAST/EiJ ENSTCUG00005008073
 protein coding gene Chr6:80060756-80063986 (-)
CBA/J ENSMUSG00210010403
 protein coding gene Chr6:79866232-79869537 (-)
DBA/2J ENSMUSG00185000860
 protein coding gene Chr6:80413271-80416576 (-)
FVB/NJ ENSMUSG00205018284
 protein coding gene Chr6:79092029-79095335 (-)
JF1/MsJ ENSUMUG00000019853
 protein coding gene Chr6:79466379-79469694 (-)
LP/J ENSMUSG00230050308
 protein coding gene Chr6:81554858-81558165 (-)
NOD/ShiLtJ ENSMUSG00190001532
 protein coding gene Chr6:79495199-79498504 (-)
NZO/HlLtJ ENSMUSG00225016370
 protein coding gene Chr6:83463000-83466315 (-)
PWK/PhJ ENSLUMG00010005746
 protein coding gene Chr6:78817209-78820523 (-)
SPRET/EiJ ENSMSPG00010035520
 protein coding gene Chr6:80971115-80974379 (-)
WSB/EiJ ENSIUOG00005017379
 protein coding gene Chr6:80432956-80436261 (-)



Homology
more
  • Human Ortholog
    HTRA2, HtrA serine peptidase 2
  • Vertebrate Orthologs
    10
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HTRA2, HtrA serine peptidase 2
  • Synonyms
    MGCA8, OMI, PARK13, PRSS25
  • Links
    NCBI Gene ID: 27429
    UniProt: O43464

  • Chr Location
    2p13.1; chr2:74529405-74533556 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human HTRA2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    69 phenotypes from 5 alleles in 7 genetic backgrounds
    4 phenotypes from multigenic genotypes
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutations of this gene cause progressive parkinsonian symptoms, loss of striatal neurons, spleen and thymus atrophy, failure to thrive, and death before 40 days of age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    106
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    632
  • Tissues
    22
  • cDNA Data
    7
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 64704 NCBI Gene Model | MGI Sequence Detail 3306 C57BL/6J ±  kb
    transcript NM_019752 RefSeq | MGI Sequence Detail 1739 ZRU/MplStud  
    polypeptide Q9JIY5 UniProt | EBI | MGI Sequence Detail 458 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      Genomic 1
      cDNA 8

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12335, MGI:2141430, MGI:97039
    References
    more
    • Summaries
      All 117
      Developmental Gene Expression 2
      Gene Ontology 20
      Phenotypes 45
    • Earliest
      J:12780 Jones JM, et al., mnd2: a new mouse model of inherited motor neuron disease. Genomics. 1993 Jun;16(3):669-77
    • Latest
      J:386463 Rias E, et al., Protocol for isolation of total RNA from mouse whole cochlea using organic solvents. STAR Protoc. 2026 Mar 20;7(1):104376
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory