Sequence Detail

ID/Version

Q9JIY5 Q9R108 (UniProt | EBI)

Last sequence update: 2002-03-27
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Serine protease HTRA2, mitochondrial; EC=3.4.21.108;AltName: Full=High temperature requirement protein A2; Short=HtrA2;AltName: Full=Omi stress-regulated endoprotease;AltName: Full=Serine protease 25;AltName: Full=Serine prot

Provider

SWISS-PROT

Sequence

Polypeptide 458 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Htra2	HtrA serine peptidase 2	76	97	14	11

Sequence references in MGI

J:64479 Gray CW, et al., Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response. Eur J Biochem. 2000 Sep;267(18):5699-710
J:182411 Verhagen AM, et al., HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins. J Biol Chem. 2002 Jan 4;277(1):445-54
J:198601 Kim JB, et al., Identification of a novel anti-apoptotic E3 ubiquitin ligase that ubiquitinates antagonists of inhibitor of apoptosis proteins SMAC, HtrA2, and ARTS. J Biol Chem. 2013 Apr 26;288(17):12014-21
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89