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Akap8 Gene Detail
Summary
  • Symbol
    Akap8
  • Name
    A kinase (PRKA) anchor protein 8
  • Synonyms
    1200016A02Rik, AKAP95
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928488
    NCBI Gene: 56399
  • Gene Overview
    MyGene.info: AKAP8
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:32303676-32321153 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 17.48 cM, cytoband B2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    109 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928488
protein coding gene Chr17:32303672-32321324 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023501
protein coding gene Chr17:32145733-32163223 (-)
A/J MGP_AJ_G0023458
protein coding gene Chr17:31077163-31094601 (-)
AKR/J MGP_AKRJ_G0023424
protein coding gene Chr17:31361411-31378746 (-)
BALB/cJ MGP_BALBcJ_G0023463
protein coding gene Chr17:31170660-31188351 (-)
C3H/HeJ MGP_C3HHeJ_G0023225
protein coding gene Chr17:31760813-31779736 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023906
protein coding gene Chr17:33235630-33253075 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021380
protein coding gene Chr17:28176618-28194729 (-)
CAST/EiJ MGP_CASTEiJ_G0022726
protein coding gene Chr17:31814510-31831926 (-)
CBA/J MGP_CBAJ_G0023200
protein coding gene Chr17:34699758-34717164 (-)
DBA/2J MGP_DBA2J_G0023330
protein coding gene Chr17:30453902-30471514 (-)
FVB/NJ MGP_FVBNJ_G0023300
protein coding gene Chr17:30279286-30297839 (-)
LP/J MGP_LPJ_G0023408
protein coding gene Chr17:32363006-32380380 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023318
protein coding gene Chr17:33758230-33775615 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023948
protein coding gene Chr17:31719188-31737132 (-)
PWK/PhJ MGP_PWKPhJ_G0022475
protein coding gene Chr17:29346315-29364903 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022294
protein coding gene Chr17:29739894-29757486 (-)
WSB/EiJ MGP_WSBEiJ_G0022788
protein coding gene Chr17:31702446-31721269 (-)



Homology
more
  • Human Ortholog
    AKAP8, A-kinase anchoring protein 8
  • Vertebrate Orthologs
    8
  • Human Ortholog
    AKAP8, A-kinase anchoring protein 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AKAP-8, AKAP95, AKAP 95, AKAP-95
  • Links
    NCBI Gene ID: 10270
    neXtProt AC: NX_O43823
    UniProt: O43823

  • Chr Location
    19p13.12; chr19:15353521-15379815 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotypes from multigenic genotypes
    1 images
    7 phenotype references
Mice homozygous for a gene trap insertion are viable and overtly normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024045 Ensembl Gene Model | MGI Sequence Detail 17478 C57BL/6J ±  kb
transcript ENSMUST00000002699 Ensembl | MGI Sequence Detail 3695 Not Applicable  
polypeptide ENSMUSP00000002699 Ensembl | MGI Sequence Detail 687 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 226
    cDNA 224
    Primer pair 1
    Other 1

    Microarray probesets 8
Other
Accession IDs
less
MGI:1914712, MGI:2146780, MGI:2146969
References
more
  • Summaries
    All 44
    Developmental Gene Expression 6
    Gene Ontology 9
    Phenotypes 7
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:261596 Schilders K, et al., Generation of a biotinylatable Sox2 mouse model to identify Sox2 complexes in vivo. Transgenic Res. 2018 Feb;27(1):75-85

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory