About   Help   FAQ
Akap8
Gene Detail
 Symbol
Name
ID
Akap8
A kinase (PRKA) anchor protein 8
MGI:1928488
Synonyms 1200016A02Rik, AKAP95
Feature Type protein coding gene
Genetic Map
Chromosome 17
17.48 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:32303676-32321153 bp, - strand
From NCBI annotation of GRCm38

  17478 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4278  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Akap8

Human
homologs
Human Homolog AKAP8, A kinase (PRKA) anchor protein 8
NCBI Gene ID 10270
neXtProt AC  NX_O43823
Human Synonyms  AKAP-8, AKAP95, AKAP 95, AKAP-95
Human Chr (Location)  19p13.1; chr19:15353521-15379824 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(39) : Gene trapped(37) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trap insertion are viable and overtly normal.
 
Phenotype Images(1)
Interactions
Akap8 interacts with 211 markers (Mir7-1, Mir15a, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process mitotic chromosome condensation, phosphorylation
Component condensed chromosome, female pronucleus, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (132)    Tissues (120)    Images (30)
Theiler Stages: 5, 19, 22, 23, 28
Assay TypeResults
RNA in situ 132
cDNA source data(223)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(225) cDNA(224) Primer pair(1)
Microarray probesets(8)
Other database
links
Ensembl Gene ModelENSMUSG00000024045 (Evidence)
Entrez Gene56399 (Evidence)
UniGene328945
DFCITC1572210, TC1597063, TC1602696, TC1603016, TC1604116
DoTSDT.101142077, DT.101252771, DT.102557613, DT.110556506, DT.50317113, DT.91338174, DT.94365735, DT.94365790, DT.97385230
NIA Mouse Gene IndexU037662
Consensus CDS ProjectCCDS37555.1
International Mouse Knockout Project StatusAkap8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 56399 NCBI Gene Model | MGI Sequence Detail 17478 C57BL/6J ±  kb
transcript NM_019774 RefSeq | MGI Sequence Detail 3695 C57BL/6 
polypeptide Q9DBR0 UniProt | EBI | MGI Sequence Detail 687 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(12) UniProt(3)
Polymorphisms SNPs within 2kb(109 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007071 A-kinase anchoring protein 95 (AKAP95)
InterPro IPR015880 Zinc finger, C2H2-like
Protein Ontology PR:000003894 A-kinase anchor protein 8
Graphical View of Protein Domain Structure
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:156017 Yokoyama S, et al., A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48
All references(43)
Other
accession IDs
MGI:1914712, MGI:2146780, MGI:2146969

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/23/2014
MGI 5.19
The Jackson Laboratory