Rassf1
Gene Detail

Symbol Name ID

Rassf1 Ras association (RalGDS/AF-6) domain family member 1 MGI:1928386

Synonyms

123F protein, NORE2A, Rassf1A, Rassf1B, Rassf1C, RDA32, REH3P21

Feature Type

protein coding gene

Genetic Map

Chromosome 9

58.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr9:107551555-107562263 bp, + strand From VEGA annotation of GRCm38   10709 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:10499  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 zebrafish

Gene Tree: Rassf1

Human homologs

Human Homolog		RASSF1, Ras association (RalGDS/AF-6) domain family member 1
NCBI Gene ID		11186
neXtProt AC		NX_Q9NS23
Human Synonyms		123F2, NORE2A, RASSF1A, RDA32, REH3P21
Human Chr (Location)		3p21.3; chr3:50367217-50378367 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human RASSF1

Alleles and phenotypes

All alleles(11) : Targeted(5) Gene trapped(6)
 

Homozygous and heterozygous null mice display increased tumor incidence, especially of lung adenomas and lymphomas, and increased sensitivity to chemically induced tumors.

 

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	cell cycle, cell cycle arrest, ...
Component	cytoplasm, cytoskeleton, ...
Function	identical protein binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (5)    Tissues (3)    Images (1)
Theiler Stages: 23, 28

Assay Type	Results
RNA in situ	1
RT-PCR	4

cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(10) cDNA(9) Primer pair(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000030554 (Evidence)
Ensembl Gene Model	ENSMUSG00000010067 (Evidence)
Entrez Gene	56289 (Evidence)
DFCI	TC1579409, TC1599223, TC1608806, TC1685241, TC1689033, TC1690120
Consensus CDS Project	CCDS23494.1, CCDS57699.1
International Mouse Knockout Project Status	Rassf1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030554	VEGA Gene Model | MGI Sequence Detail	10709	C57BL/6J
transcript	OTTMUST00000075659	VEGA | MGI Sequence Detail	1783	Not Applicable
polypeptide	OTTMUSP00000039712	VEGA | MGI Sequence Detail	344	Not Applicable

All sequences(65) RefSeq(4) UniProt(6)

Polymorphisms

SNPs(38 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro	IPR000159	Ras-association
InterPro	IPR011524	SARAH
Protein Ontology	PR:000013763	ras association domain-containing protein 1

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:191036 van der Weyden L, et al., Loss of RASSF1A synergizes with deregulated RUNX2 signaling in tumorigenesis. Cancer Res. 2012 Aug 1;72(15):3817-27
All references(47)

Other accession IDs

MGI:2143239