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Rassf1
Gene Detail
Symbol

Name
ID
Rassf1
Ras association (RalGDS/AF-6) domain family member 1
MGI:1928386
Synonyms
123F protein, NORE2A, Rassf1A, Rassf1B, Rassf1C, RDA32, REH3P21
Feature Type
protein coding gene
Genetic Map
Chromosome 9
58.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:107551555-107562267 bp, + strand
From VEGA annotation of GRCm38

  10713 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10499  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: RASSF1
Gene Tree: Rassf1

Human
homologs
RASSF1, Ras association (RalGDS/AF-6) domain family member 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 11186
neXtProt AC: NX_Q9NS23

Human Synonyms: 123F2, NORE2A, RASSF1A, RDA32, REH3P21

Human Chr (Location): 3p21.3; chr3:50329786-50340936 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human RASSF1

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(6) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous and heterozygous null mice display increased tumor incidence, especially of lung adenomas and lymphomas, and increased sensitivity to chemically induced tumors.
 
Interactions
Rassf1 interacts with 218 markers (Mir1b, Mir15a, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process cell cycle, cell cycle arrest, ...
Component cytoplasm, cytoskeleton, ...
Function identical protein binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (5)    Tissues (3)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
RT-PCR 4
cDNA source data(8)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rassf1 ; ZFIN rassf1    NEW 
Molecular
reagents
All nucleic(10) cDNA(9) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000030554 (Evidence)
Ensembl Gene Model ENSMUSG00000010067 (Evidence)
Entrez Gene 56289 (Evidence)
DFCI TC1579409, TC1599223, TC1608806, TC1685241, TC1689033, TC1690120
Consensus CDS Project CCDS23494.1, CCDS57699.1
International Mouse Phenotyping Consortium Status Rassf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030554 VEGA Gene Model | MGI Sequence Detail 10713 C57BL/6J ±  kb
transcript OTTMUST00000075659 VEGA | MGI Sequence Detail 1783 Not Applicable 
polypeptide OTTMUSP00000039712 VEGA | MGI Sequence Detail 344 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(6) UniProt(5)
Polymorphisms
SNPs within 2kb(74 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
InterPro IPR000159 Ras-associating (RA) domain
InterPro IPR011524 SARAH domain
InterPro IPR029071 Ubiquitin-related domain
Protein Ontology PR:000013763 ras association domain-containing protein 1
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:217712 Pefani DE, et al., RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2. Nat Cell Biol. 2014 Oct;16(10):962-71, 1-8
All references(49)
Other
accession IDs
MGI:2143239

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory