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Rassf1
Gene Detail
 Symbol
Name
ID
Rassf1
Ras association (RalGDS/AF-6) domain family member 1
MGI:1928386
Synonyms 123F protein, NORE2A, Rassf1A, Rassf1B, Rassf1C, RDA32, REH3P21
Feature Type protein coding gene
Genetic Map
Chromosome 9
58.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:107551555-107562263 bp, + strand
From VEGA annotation of GRCm38

  10709 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10499  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Rassf1

Human
homologs
Human Homolog RASSF1, Ras association (RalGDS/AF-6) domain family member 1
NCBI Gene ID 11186
neXtProt AC  NX_Q9NS23
Human Synonyms  123F2, NORE2A, RASSF1A, RDA32, REH3P21
Human Chr (Location)  3p21.3; chr3:50329786-50340936 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human RASSF1
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(6) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous and heterozygous null mice display increased tumor incidence, especially of lung adenomas and lymphomas, and increased sensitivity to chemically induced tumors.
 
Interactions
Rassf1 interacts with 218 markers (Mir1b, Mir15a, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process cell cycle, cell cycle arrest, ...
Component cytoplasm, cytoskeleton, ...
Function identical protein binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (5)    Tissues (3)    Images (1)
Theiler Stages: 23, 28
Assay TypeResults
RNA in situ 1
RT-PCR 4
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(9) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000030554 (Evidence)
Ensembl Gene ModelENSMUSG00000010067 (Evidence)
Entrez Gene56289 (Evidence)
DFCITC1579409, TC1599223, TC1608806, TC1685241, TC1689033, TC1690120
Consensus CDS ProjectCCDS23494.1, CCDS57699.1
International Mouse Knockout Project StatusRassf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030554 VEGA Gene Model | MGI Sequence Detail 10709 C57BL/6J ±  kb
transcript OTTMUST00000075659 VEGA | MGI Sequence Detail 1783 Not Applicable 
polypeptide OTTMUSP00000039712 VEGA | MGI Sequence Detail 344 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(6) UniProt(5)
Polymorphisms SNPs within 2kb(74 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro IPR000159 Ras-association
InterPro IPR011524 SARAH domain
Protein Ontology PR:000013763 ras association domain-containing protein 1
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:209114 Gordon M, et al., The tumor suppressor gene, RASSF1A, is essential for protection against inflammation -induced injury. PLoS One. 2013;8(10):e75483
All references(48)
Other
accession IDs
MGI:2143239

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory