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Ireb2 Gene Detail
Summary
  • Symbol
    Ireb2
  • Name
    iron responsive element binding protein 2
  • Synonyms
    D9Ertd85e, Irp2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928268
    NCBI Gene: 64602
Location & Maps
more
  • Sequence Map
    Chr9:54863755-54912534 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      48780 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 29.81 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    IREB2, iron responsive element binding protein 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IREB2, iron responsive element binding protein 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ACO3, IRP2, IRP2AD
  • Links
    NCBI Gene ID: 3658
    neXtProt AC: NX_P48200

  • Chr Location
    15q25.1; chr15:78438176-78501456 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 4 alleles in 5 genetic backgrounds
    11 phenotypes from multigenic genotypes
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous disruption of this gene results in behavioral abnormalities and nervous system degeneration. Another homozygous mutation results in normal neuropathology but altered body iron distribution and microcytosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032293 Ensembl Gene Model | MGI Sequence Detail 48780 C57BL/6J ±  kb
transcript ENSMUST00000034843 Ensembl | MGI Sequence Detail 5808 Not Applicable  
polypeptide ENSMUSP00000034843 Ensembl | MGI Sequence Detail 963 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    245 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000009102 iron-responsive element-binding protein 2
  • InterPro Domains
    IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain
    IPR015931 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3
    IPR015932 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 2
    IPR015928 Aconitase/3-isopropylmalate dehydratase, swivel
    IPR000573 Aconitase A/isopropylmalate dehydratase small subunit, swivel domain
    IPR018136 Aconitase family, 4Fe-4S cluster binding site
    IPR006249 Aconitase/Iron-responsive element-binding protein 2
    IPR015937 Aconitase/isopropylmalate dehydratase
    IPR029755 Iron regulatory protein 2
Molecular
Reagents
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  • All nucleic 226
    cDNA 224
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
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MGI:1098541
References
more
  • Summaries
    All 72
    Developmental Gene Expression 8
    Gene Ontology 13
    Phenotypes 34
  • Earliest
    J:66321 Henderson BR, et al., Characterization of a second RNA-binding protein in rodents with specificity for iron-responsive elements. J Biol Chem. 1993 Dec 25;268(36):27327-34
  • Latest
    J:224212 Vendrell V, et al., Otx2 is a target of N-myc and acts as a suppressor of sensory development in the mammalian cochlea. Development. 2015 Aug 15;142(16):2792-800

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory