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Ggcx Gene Detail
Summary
  • Symbol
    Ggcx
  • Name
    gamma-glutamyl carboxylase
  • Synonyms
    vitamin K-dependent carboxylase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927655
    NCBI Gene: 56316
  • Gene Overview
    MyGene.info: GGCX
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:72414308-72430712 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 32.27 cM, cytoband C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    133 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927655
protein coding gene Chr6:72414286-72431106 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030876
protein coding gene Chr6:72966943-72983338 (+)
A/J MGP_AJ_G0030846
protein coding gene Chr6:70136824-70153294 (+)
AKR/J MGP_AKRJ_G0030775
protein coding gene Chr6:72201823-72218295 (+)
BALB/cJ MGP_BALBcJ_G0030857
protein coding gene Chr6:70164375-70180761 (+)
C3H/HeJ MGP_C3HHeJ_G0030855
protein coding gene Chr6:112022783-112039232 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031315
protein coding gene Chr6:74881572-74897976 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028504
protein coding gene Chr6:69282184-69299420 (+)
CAST/EiJ MGP_CASTEiJ_G0029965
protein coding gene Chr6:72064622-72083843 (+)
CBA/J MGP_CBAJ_G0030544
protein coding gene Chr6:77931932-77948456 (+)
DBA/2J MGP_DBA2J_G0030696
protein coding gene Chr6:69530916-69547825 (+)
FVB/NJ MGP_FVBNJ_G0030649
protein coding gene Chr6:68922167-68938580 (+)
LP/J MGP_LPJ_G0030775
protein coding gene Chr6:72874793-72891197 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030684
protein coding gene Chr6:81327192-81343399 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031341
protein coding gene Chr6:72015166-72031632 (+)
PWK/PhJ MGP_PWKPhJ_G0029681
protein coding gene Chr6:68438030-68454803 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029509
protein coding gene Chr6:70740881-70757222 (+)
WSB/EiJ MGP_WSBEiJ_G0030047
protein coding gene Chr6:72379534-72395874 (+)



Homology
more
  • Human Ortholog
    GGCX, gamma-glutamyl carboxylase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GGCX, gamma-glutamyl carboxylase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    VKCFD1
  • Links
    NCBI Gene ID: 2677
    neXtProt AC: NX_P38435
    UniProt: P38435

  • Chr Location
    2p11.2; chr2:85544720-85561534 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 3 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Approximately 50% of embryos homozygous for a knock-out allele die between E9.5 and E18 while those surviving to term die of massive intra-abdominal hemorrhage shortly after birth with no evidence of ectopic calcification.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000053460 Ensembl Gene Model | MGI Sequence Detail 16405 C57BL/6J ±  kb
    transcript ENSMUST00000065906 Ensembl | MGI Sequence Detail 2929 Not Applicable  
    polypeptide ENSMUSP00000070109 Ensembl | MGI Sequence Detail 757 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      Genomic 2
      cDNA 9
      Primer pair 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 12
    • Earliest
      J:65775 Begley GS, et al., A conserved motif within the vitamin K-dependent carboxylase gene is widely distributed across animal phyla. J Biol Chem. 2000 Nov 17;275(46):36245-9
    • Latest
      J:262230 Lacombe J, et al., VKOR paralog VKORC1L1 supports vitamin K-dependent protein carboxylation in vivo. JCI Insight. 2018 Jan 11;3(1)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory