Ggcx
Gene Detail

Symbol Name ID

Ggcx gamma-glutamyl carboxylase MGI:1927655

Synonyms

vitamin K-dependent carboxylase

Feature Type

protein coding gene

Genetic Map

Chromosome 6

32.27 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr6:72414308-72430712 bp, + strand From VEGA annotation of GRCm38   16405 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:639  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 zebrafish

Protein SuperFamily: vitamin K-dependent gamma-carboxylase
Gene Tree: Ggcx

Human homologs

Human Homolog		GGCX, gamma-glutamyl carboxylase
NCBI Gene ID		2677
neXtProt AC		NX_P38435
Human Synonyms		VKCFD1
Human Chr (Location)		2p12; chr2:85771978-85788657 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human GGCX

Alleles and phenotypes

All alleles(5) : Targeted(4) Gene trapped(1)
 

Approximately 50% of embryos homozygous for a knock-out allele die between E9.5 and E18 while those surviving to term die of massive intra-abdominal hemorrhage shortly after birth with no evidence of ectopic calcification.

 

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	metabolic process, peptidyl-glutamic acid carboxylation
Component	endoplasmic reticulum, integral to membrane, ...
Function	gamma-glutamyl carboxylase activity, lyase activity, ...

External Resources: FuncBase

Expression

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(11) Genomic(1) cDNA(9) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000026391 (Evidence)
Ensembl Gene Model	ENSMUSG00000053460 (Evidence)
Entrez Gene	56316 (Evidence)
DFCI	TC1578618, TC1599770
NIA Mouse Gene Index	U007037
EC	4.1.1.90
Consensus CDS Project	CCDS20242.1
International Mouse Knockout Project Status	Ggcx

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026391	VEGA Gene Model | MGI Sequence Detail	16405	C57BL/6J
transcript	OTTMUST00000065266	VEGA | MGI Sequence Detail	2929	Not Applicable
polypeptide	OTTMUSP00000032504	VEGA | MGI Sequence Detail	757	Not Applicable

All sequences(33) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(101 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011020	HTTM
InterPro	IPR011051	RmlC-like cupin domain
InterPro	IPR014710	RmlC-like jelly roll fold
InterPro	IPR007782	Vitamin K-dependent gamma-carboxylase
Protein Ontology	PR:000007956	vitamin K-dependent gamma-carboxylase

References

(Earliest) J:65775 Begley GS, et al., A conserved motif within the vitamin K-dependent carboxylase gene is widely distributed across animal phyla. J Biol Chem. 2000 Nov 17;275(46):36245-9
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(31)