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Shoc2 Gene Detail
Summary
  • Symbol
    Shoc2
  • Name
    soc-2 (suppressor of clear) homolog (C. elegans)
  • Synonyms
    mKIAA0862, Sur-8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927197
    NCBI Gene: 56392
Location & Maps
more
  • Sequence Map
    Chr19:53944306-54033268 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      88963 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SHOC2, SHOC2 leucine-rich repeat scaffold protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SHOC2, SHOC2 leucine-rich repeat scaffold protein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SIAA0862, SOC2, SUR8
  • Links
    NCBI Gene ID: 8036
    neXtProt AC: NX_Q9UQ13

  • Chr Location
    10q25; chr10:110919543-111013667 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 7219
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: SHOC2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human SHOC2 associations

Human Disease Mouse Models
       Noonan Syndrome-Like Disorder with Loose Anagen Hair; NSLH   OMIM: 607721
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 2 alleles in 3 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    41
  • Gene trapped
    37
  • Targeted
    4
Shoc2 is essential for embryonic development, as germline deletion results in early embryonic lethality. Endothelial cell-specific deletion causes defects in cardiac development, and results in late embryonic/early fetal lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024976 Ensembl Gene Model | MGI Sequence Detail 88963 C57BL/6J ±  kb
transcript ENSMUST00000169861 Ensembl | MGI Sequence Detail 4065 Not Applicable  
polypeptide ENSMUSP00000127932 Ensembl | MGI Sequence Detail 582 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    246 from dbSNP Build 137
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000032078 leucine-rich repeat protein SHOC-2
  • InterPro Domains
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain, L domain-like
    IPR003591 Leucine-rich repeat, typical subtype
Molecular
Reagents
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  • All nucleic 105
    cDNA 105

    Microarray probesets 5
Other
Accession IDs
less
MGI:2147642
References
more
  • Summaries
    All 30
    Developmental Gene Expression 2
    Gene Ontology 1
    Phenotypes 8
  • Earliest
    J:48584 Sieburth DS, et al., SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans. Cell. 1998 Jul 10;94(1):119-30
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory