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Shoc2
Gene Detail
Symbol

Name
ID
Shoc2
soc-2 (suppressor of clear) homolog (C. elegans)
MGI:1927197
Synonyms
mKIAA0862, Sur-8
Feature Type
protein coding gene
Genetic Map
Chromosome 19
48.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr19:53944306-54033268 bp, + strand
From Ensembl annotation of GRCm38

  88963 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7219  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Shoc2

Human
homologs
Human Homolog SHOC2, soc-2 suppressor of clear homolog (C. elegans)
NCBI Gene ID 8036
neXtProt AC  NX_Q9UQ13
Human Synonyms  SIAA0862, SOC2, SUR8
Human Chr (Location)  10q25; chr10:110919543-111013667 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human SHOC2
Mutations,
alleles, and
phenotypes
All mutations/alleles(41) : Gene trapped(37) Targeted(4)
 
Shoc2 is essential for embryonic development, as germline deletion results in early embryonic lethality. Endothelial cell-specific deletion causes defects in cardiac development, and results in late embryonic/early fetal lethality.
 
Interactions
Shoc2 interacts with 361 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process positive regulation of Ras protein signal transduction
Component cytoplasm, nucleoplasm, ...
Function protein phosphatase binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (28)    Tissues (4)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 28
cDNA source data(105)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(105) cDNA(105)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000024976 (Evidence)
Entrez Gene56392 (Evidence)
UniGene228669
DFCITC1607431, TC1577109, TC1621020
NIA Mouse Gene IndexU368359, U364046, U043740
Consensus CDS ProjectCCDS29904.1
International Mouse Knockout Project StatusShoc2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024976 Ensembl Gene Model | MGI Sequence Detail 88963 C57BL/6J ±  kb
transcript ENSMUST00000169861 Ensembl | MGI Sequence Detail 4065 Not Applicable 
polypeptide ENSMUSP00000127932 Ensembl | MGI Sequence Detail 582 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(8) UniProt(3)
Polymorphisms
SNPs within 2kb(246 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001611 Leucine-rich repeat
InterPro IPR025875 Leucine rich repeat 4
InterPro IPR003591 Leucine-rich repeat, typical subtype
Protein Ontology PR:000032078 leucine-rich repeat protein SHOC-2
References
(Earliest) J:48584 Sieburth DS, et al., SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans. Cell. 1998 Jul 10;94(1):119-30
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(33)
Other
accession IDs
MGI:2147642

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory