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Shoc2 Gene Detail
Summary
  • Symbol
    Shoc2
  • Name
    Shoc2, leucine rich repeat scaffold protein
  • Synonyms
    mKIAA0862, soc-2 (suppressor of clear) homolog (C. elegans), Sur-8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927197
    NCBI Gene: 56392
  • Gene Overview
    MyGene.info: SHOC2
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:53944306-54033268 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 48.83 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    246 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927197
protein coding gene Chr19:53944232-54033280 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025252
protein coding gene Chr19:54125923-54226304 (+)
A/J MGP_AJ_G0025228
protein coding gene Chr19:51462000-51552475 (+)
AKR/J MGP_AKRJ_G0025197
protein coding gene Chr19:53086152-53173251 (+)
BALB/cJ MGP_BALBcJ_G0025223
protein coding gene Chr19:51548264-51638263 (+)
C3H/HeJ MGP_C3HHeJ_G0024983
protein coding gene Chr19:53303765-53396546 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025666
protein coding gene Chr19:55425380-55529785 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023078
protein coding gene Chr19:50449239-50534185 (+)
CAST/EiJ MGP_CASTEiJ_G0024448
protein coding gene Chr19:53271107-53362021 (+)
CBA/J MGP_CBAJ_G0024963
protein coding gene Chr19:58197444-58299786 (+)
DBA/2J MGP_DBA2J_G0025095
protein coding gene Chr19:51273378-51364722 (+)
FVB/NJ MGP_FVBNJ_G0025056
protein coding gene Chr19:50989276-51081545 (+)
LP/J MGP_LPJ_G0025181
protein coding gene Chr19:54013514-54110065 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025089
protein coding gene Chr19:57615745-57712053 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025724
protein coding gene Chr19:53279709-53372963 (+)
PWK/PhJ MGP_PWKPhJ_G0024196
protein coding gene Chr19:51180547-51273359 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023999
protein coding gene Chr19:51955339-52056824 (+)
WSB/EiJ MGP_WSBEiJ_G0024518
protein coding gene Chr19:53407916-53502324 (+)



Homology
more
  • Human Ortholog
    SHOC2, SHOC2, leucine rich repeat scaffold protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SHOC2, SHOC2, leucine rich repeat scaffold protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SIAA0862, SOC2, SUR8
  • Links
    NCBI Gene ID: 8036
    neXtProt AC: NX_Q9UQ13
    UniProt: Q9UQ13

  • Chr Location
    10q25.2; chr10:110919370-111013667 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 7219
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SHOC2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 3 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Shoc2 is essential for embryonic development, as germline deletion results in early embryonic lethality. Endothelial cell-specific deletion causes defects in cardiac development, and results in late embryonic/early fetal lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024976 Ensembl Gene Model | MGI Sequence Detail 88963 C57BL/6J ±  kb
    transcript ENSMUST00000169861 Ensembl | MGI Sequence Detail 4065 Not Applicable  
    polypeptide ENSMUSP00000127932 Ensembl | MGI Sequence Detail 582 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 106
      cDNA 106

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2147642
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 8
    • Earliest
      J:48584 Sieburth DS, et al., SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans. Cell. 1998 Jul 10;94(1):119-30
    • Latest
      J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory