Shoc2
Gene Detail

Symbol Name ID

Shoc2 soc-2 (suppressor of clear) homolog (C. elegans) MGI:1927197

Synonyms

mKIAA0862, Sur-8

Feature Type

protein coding gene

Genetic Map

Chromosome 19

48.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr19:53944306-54033268 bp, + strand From Ensembl annotation of GRCm38   88963 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7219  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Shoc2

Human homologs

Human Homolog		SHOC2, soc-2 suppressor of clear homolog (C. elegans)
NCBI Gene ID		8036
neXtProt AC		NX_Q9UQ13
Human Synonyms		SIAA0862, SOC2, SUR8
Human Chr (Location)		10q25; chr10:112679301-112773425 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SHOC2

Alleles and phenotypes

All alleles(41) : Targeted(4) Gene trapped(37)
 

Shoc2 is essential for embryonic development, as germline deletion results in early embryonic lethality. Endothelial cell-specific deletion causes defects in cardiac development, and results in late embryonic/early fetal lethality.

 

Gene Ontology (GO) classifications

All GO classifications: (5 annotations)

Process	positive regulation of Ras protein signal transduction
Component	cytoplasm, nucleus, ...
Function	protein phosphatase binding

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (28)    Tissues (4)    Images (18)
Theiler Stages: 23

Assay Type	Results
RNA in situ	28

cDNA source data(105)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(105) cDNA(105)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000024976 (Evidence)
Entrez Gene	56392 (Evidence)
UniGene	228669
DFCI	TC1577109, TC1607431, TC1621020
NIA Mouse Gene Index	U043740, U364046, U368359
Consensus CDS Project	CCDS29904.1
International Mouse Knockout Project Status	Shoc2

Sequences

Length	Strain/Species
genomic	ENSMUSG00000024976	Ensembl Gene Model | MGI Sequence Detail	88963	C57BL/6J
transcript	ENSMUST00000169861	Ensembl | MGI Sequence Detail	4065	Not Applicable
polypeptide	ENSMUSP00000127932	Ensembl | MGI Sequence Detail	582	Not Applicable

All sequences(31) RefSeq(4) UniProt(2)

Polymorphisms

SNPs(221 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001611	Leucine-rich repeat
InterPro	IPR025875	Leucine rich repeat 4
InterPro	IPR003591	Leucine-rich repeat, typical subtype
Protein Ontology	PR:000032078	leucine-rich repeat protein SHOC-2

References

(Earliest) J:48584 Sieburth DS, et al., SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans. Cell. 1998 Jul 10;94(1):119-30
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(33)

Other accession IDs

MGI:2147642