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Arl6 Gene Detail
Summary
  • Symbol
    Arl6
  • Name
    ADP-ribosylation factor-like 6
  • Synonyms
    1110018H24Rik, 2210411E14Rik, BBS3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927136
    NCBI Gene: 56297
  • Gene Overview
    MyGene.info: ARL6
Location & Maps
more
  • Sequence Map
    Chr16:59612949-59639391 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      26443 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 34.83 cM, cytoband C1.2
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ARL6, ADP ribosylation factor like GTPase 6
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ARL6, ADP ribosylation factor like GTPase 6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BBS3, RP55
  • Links
    NCBI Gene ID: 84100
    neXtProt AC: NX_Q9H0F7

  • Chr Location
    3q11.2; chr3:97764521-97801242 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    4 with human ARL6 associations

Human Disease Mouse Models
       Bardet-Biedl Syndrome 1; BBS1   OMIM: 209900
Bardet-Biedl Syndrome 3; BBS3   OMIM: 600151
Retinitis Pigmentosa 55; RP55   OMIM: 613575
Retinitis Pigmentosa; RP   OMIM: 268000
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele exhibit a disorganized photoreceptor inner segment and craniofacial abnormalitries. Male mice are sterile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026308 VEGA Gene Model | MGI Sequence Detail 26443 C57BL/6J ±  kb
transcript OTTMUST00000065074 VEGA | MGI Sequence Detail 811 Not Applicable  
polypeptide OTTMUSP00000032382 VEGA | MGI Sequence Detail 194 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    391 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000004290 ADP-ribosylation factor-like protein 6
  • InterPro Domains
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR006689 Small GTPase superfamily, ARF/SAR type
    IPR024156 Small GTPase superfamily, ARF type
    IPR005225 Small GTP-binding protein domain
Molecular
Reagents
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  • All nucleic 37
    cDNA 36
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGI:1917645, MGI:1923557
References
more
  • Summaries
    All 35
    Developmental Gene Expression 4
    Gene Ontology 8
    Phenotypes 4
  • Earliest
    J:62458 Ingley E, et al., A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit. FEBS Lett. 1999 Oct 1;459(1):69-74
  • Latest
    J:226028 Lewandowski JP, et al., Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Dev Biol. 2015 Oct 1;406(1):92-103

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory