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Arl6
Gene Detail
 Symbol
Name
ID
Arl6
ADP-ribosylation factor-like 6
MGI:1927136
Synonyms 1110018H24Rik, 2210411E14Rik, BBS3
Feature Type protein coding gene
Genetic Map
Chromosome 16
34.83 cM, cytoband C1.2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:59612949-59639391 bp, - strand
From VEGA annotation of GRCm38

  26443 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12960  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: ADP-ribosylation factor
Gene Tree: Arl6

Human
homologs
Human Homolog ARL6, ADP-ribosylation factor-like 6
NCBI Gene ID 84100
neXtProt AC  NX_Q9H0F7
Human Synonyms  BBS3, RP55
Human Chr (Location)  3q11.2; chr3:97764521-97801242 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human ARL6
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted allele exhibit a disorganized photoreceptor inner segment and craniofacial abnormalitries. Male mice are sterile.
 
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process cell projection organization, cilium assembly, ...
Component cell projection, cytoplasm, ...
Function GTP binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (19)    Tissues (12)   
Theiler Stages: 9, 11, 12, 13
Assay TypeResults
RNA in situ 19
cDNA source data(34)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(37) cDNA(36) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000026308 (Evidence)
Ensembl Gene ModelENSMUSG00000022722 (Evidence)
Entrez Gene56297 (Evidence)
UniGene392505
DFCITC1578776, TC1634413
DoTSDT.486134
NIA Mouse Gene IndexU037166
Consensus CDS ProjectCCDS28259.1
International Mouse Knockout Project StatusArl6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026308 VEGA Gene Model | MGI Sequence Detail 26443 C57BL/6J ±  kb
transcript OTTMUST00000065074 VEGA | MGI Sequence Detail 811 Not Applicable 
polypeptide OTTMUSP00000032382 VEGA | MGI Sequence Detail 194 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(5) UniProt(5)
Polymorphisms SNPs within 2kb(398 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR006689 Small GTPase superfamily, ARF/SAR type
InterPro IPR024156 Small GTPase superfamily, ARF type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000004290 ADP-ribosylation factor-like protein 6
References (Earliest) J:62458 Ingley E, et al., A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit. FEBS Lett. 1999 Oct 1;459(1):69-74
(Latest) J:199437 Soetedjo L, et al., Targeting of vasoactive intestinal peptide receptor 2, VPAC2, a secretin family G-protein coupled receptor, to primary cilia. Biol Open. 2013 Jul 15;2(7):686-94
All references(36)
Other
accession IDs
MGI:1917645, MGI:1923557

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory