Arl6
Gene Detail

Symbol Name ID

Arl6 ADP-ribosylation factor-like 6 MGI:1927136

Synonyms

1110018H24Rik, 2210411E14Rik, BBS3

Feature Type

protein coding gene

Genetic Map

Chromosome 16

34.83 cM, cytoband C1.2
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr16:59612949-59639391 bp, - strand From VEGA annotation of GRCm38   26443 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:12960  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: ADP-ribosylation factor
Gene Tree: Arl6

Human homologs

Human Homolog		ARL6, ADP-ribosylation factor-like 6
NCBI Gene ID		84100
neXtProt AC		NX_Q9H0F7
Human Synonyms		BBS3, RP55
Human Chr (Location)		3q11.2; chr3:97483595-97517373 (+)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human ARL6

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for a targeted allele exhibit a disorganized photoreceptor inner segment and craniofacial abnormalitries. Male mice are sterile.

 

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	cell projection organization, cilium assembly, ...
Component	cell projection, cytoplasm, ...
Function	GTP binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (19)    Tissues (12)   
Theiler Stages: 9, 11, 12, 13

Assay Type	Results
RNA in situ	19

cDNA source data(36)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(39) cDNA(38) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000026308 (Evidence)
Ensembl Gene Model	ENSMUSG00000022722 (Evidence)
Entrez Gene	56297 (Evidence)
UniGene	392505
DFCI	TC1578776, TC1634413
DoTS	DT.486134
NIA Mouse Gene Index	U037166
Consensus CDS Project	CCDS28259.1
International Mouse Knockout Project Status	Arl6

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026308	VEGA Gene Model | MGI Sequence Detail	26443	C57BL/6J
transcript	OTTMUST00000065074	VEGA | MGI Sequence Detail	811	Not Applicable
polypeptide	OTTMUSP00000032382	VEGA | MGI Sequence Detail	194	Not Applicable

All sequences(41) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(225 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006689	Small GTPase superfamily, ARF/SAR type
InterPro	IPR024156	Small GTPase superfamily, ARF type
InterPro	IPR005225	Small GTP-binding protein domain
Protein Ontology	PR:000004290	ADP-ribosylation factor-like protein 6

References

(Earliest) J:62458 Ingley E, et al., A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit. FEBS Lett. 1999 Oct 1;459(1):69-74
(Latest) J:180524 Zhang Q, et al., Bardet-Biedl syndrome 3 (Bbs3) knockout mouse model reveals common BBS-associated phenotypes and Bbs3 unique phenotypes. Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20678-83
All references(35)

Other accession IDs

MGI:1917645, MGI:1923557