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Ppp1r15a
Gene Detail
Symbol

Name
ID
Ppp1r15a
protein phosphatase 1, regulatory (inhibitor) subunit 15A
MGI:1927072
Synonyms
Gadd34, Myd116
Feature Type
protein coding gene
Genetic Map
Chromosome 7
29.34 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:45522916-45526268 bp, - strand
From VEGA annotation of GRCm38

  3353 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8639  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle

HCOP human homology predictions: PPP1R15A
Gene Tree: Ppp1r15a

Human
homologs
PPP1R15A, protein phosphatase 1, regulatory subunit 15A
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 23645
neXtProt AC: NX_O75807

Human Synonyms: GADD34

Human Chr (Location): 19q13.2; chr19:48872392-48876062 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice show abnormal cellular responses to either ER- or oxidative- stress.
 
Interactions
Ppp1r15a interacts with 25 markers (Mir34b, Mir34c, Mir124a-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process apoptotic process, endoplasmic reticulum unfolded protein response, ...
Component cytoplasm, endoplasmic reticulum, ...
Function protein kinase binding, protein phosphatase 1 binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (39)    Tissues (26)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 6
Northern blot 30
Western blot 3
cDNA source data(90)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(94) Genomic(1) cDNA(92) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000024467 (Evidence)
Ensembl Gene Model ENSMUSG00000040435 (Evidence)
Entrez Gene 17872 (Evidence)
UniGene 4048
DFCI TC1574542
DoTS DT.101354053, DT.111012892, DT.111012939, DT.493483
NIA Mouse Gene Index U028534
Consensus CDS Project CCDS21249.1
International Mouse Phenotyping Consortium Status Ppp1r15a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024467 VEGA Gene Model | MGI Sequence Detail 3353 C57BL/6J ±  kb
transcript OTTMUST00000060014 VEGA | MGI Sequence Detail 2333 Not Applicable 
polypeptide OTTMUSP00000029250 VEGA | MGI Sequence Detail 657 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(30 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019523 Protein phosphatase 1, regulatory subunit 15A/B, C-terminal
Protein Ontology PR:000013116 protein phosphatase 1 regulatory subunit 15A
References
(Earliest) J:43409 Lord KA, et al., Sequence of MyD116 cDNA: a novel myeloid differentiation primary response gene induced by IL6. Nucleic Acids Res. 1990 May 11;18(9):2823
(Latest) J:221794 Wu H, et al., Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis. Nat Commun. 2015;6:6239
All references(54)
Other
accession IDs
MGI:1100516

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory