About   Help   FAQ
Ppp1r15a
Gene Detail
 Symbol
Name
ID
Ppp1r15a
protein phosphatase 1, regulatory (inhibitor) subunit 15A
MGI:1927072
Synonyms Gadd34, Myd116
Feature Type protein coding gene
Genetic Map
Chromosome 7
29.34 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:45522916-45526268 bp, - strand
From VEGA annotation of GRCm38

  3353 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8639  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle

Gene Tree: Ppp1r15a

Human
homologs
Human Homolog PPP1R15A, protein phosphatase 1, regulatory subunit 15A
NCBI Gene ID 23645
neXtProt AC  NX_O75807
Human Synonyms  GADD34
Human Chr (Location)  19q13.2; chr19:48872392-48876062 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice show abnormal cellular responses to either ER- or oxidative- stress.
 
Interactions
Ppp1r15a interacts with 25 markers (Mir34b, Mir34c, Mir124a-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process apoptotic process, endoplasmic reticulum unfolded protein response, ...
Component endoplasmic reticulum
Function protein kinase binding
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (39)    Tissues (26)   
Theiler Stages: 13, 15, 17, 19, 20, 21, 22, 24, 26, 28
Assay TypeResults
RNA in situ 6
Northern blot 30
Western blot 3
cDNA source data(90)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(94) Genomic(1) cDNA(92) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000024467 (Evidence)
Ensembl Gene ModelENSMUSG00000040435 (Evidence)
Entrez Gene17872 (Evidence)
UniGene4048
DFCITC1574542
DoTSDT.101354053, DT.111012892, DT.111012939, DT.493483
NIA Mouse Gene IndexU028534
Consensus CDS ProjectCCDS21249.1
International Mouse Knockout Project StatusPpp1r15a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024467 VEGA Gene Model | MGI Sequence Detail 3353 C57BL/6J ±  kb
transcript OTTMUST00000060014 VEGA | MGI Sequence Detail 2333 Not Applicable 
polypeptide OTTMUSP00000029250 VEGA | MGI Sequence Detail 657 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(30 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019523 Protein phosphatase 1, regulatory subunit 15A/B, C-terminal
Protein Ontology PR:000013116 protein phosphatase 1 regulatory subunit 15A
References (Earliest) J:43409 Lord KA, et al., Sequence of MyD116 cDNA: a novel myeloid differentiation primary response gene induced by IL6. Nucleic Acids Res. 1990 May 11;18(9):2823
(Latest) J:206084 Adolph TE, et al., Paneth cells as a site of origin for intestinal inflammation. Nature. 2013 Nov 14;503(7475):272-6
All references(51)
Other
accession IDs
MGI:1100516

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory