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Fzr1
Gene Detail
 Symbol
Name
ID
Fzr1
fizzy/cell division cycle 20 related 1 (Drosophila)
MGI:1926790
Synonyms Cdh1, Fyr
Feature Type protein coding gene
Genetic Map
Chromosome 10
39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr10:81366222-81378516 bp, - strand
From VEGA annotation of GRCm38

  12295 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9444  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Fzr1

Human
homologs
Human Homolog FZR1, fizzy/cell division cycle 20 related 1 (Drosophila)
NCBI Gene ID 51343
neXtProt AC  NX_Q9UM11
Human Synonyms  CDC20C, CDH1, FZR, FZR2, HCDH, HCDH1
Human Chr (Location)  19p13.3; chr19:3506263-3536757 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(46) : Gene trapped(40) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants die embryonically at around E9.5-E12.5 with poorly developed placentae, no placental giant cells and/or erythroblast deficiency. Homozygous MEFs undergo premature senescence. Heterozygotes exhibit learning/memory defects and/or elevatedspontaneous epithelial tumor incidence.
 
Interactions
Fzr1 interacts with 179 markers (Mir1b, Mir23a, Mir23b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process activation of anaphase-promoting complex activity, anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, ...
Component anaphase-promoting complex, nuclear membrane, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (148)    Tissues (23)    Images (18)
Theiler Stages: 1, 2, 23, 28
Assay TypeResults
RNA in situ 141
Western blot 4
RT-PCR 3
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) cDNA(12) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000030386 (Evidence)
Ensembl Gene ModelENSMUSG00000020235 (Evidence)
Entrez Gene56371 (Evidence)
NIA Mouse Gene IndexU032045
Consensus CDS ProjectCCDS24057.1
International Mouse Knockout Project StatusFzr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030386 VEGA Gene Model | MGI Sequence Detail 12295 C57BL/6J ±  kb
transcript OTTMUST00000075264 VEGA | MGI Sequence Detail 3057 Not Applicable 
polypeptide OTTMUSP00000039412 VEGA | MGI Sequence Detail 493 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(2) UniProt(7)
Polymorphisms SNPs within 2kb(19 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001680 WD40 repeat
InterPro IPR019775 WD40 repeat, conserved site
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000007725 fizzy-related protein
References (Earliest) J:59059 Inbal N, et al., The mammalian Fizzy and Fizzy-related genes are regulated at the transcriptional and post-transcriptional levels. FEBS Lett. 1999 Dec 17;463(3):350-4
(Latest) J:210312 Lane SI, et al., Non-canonical function of spindle assembly checkpoint proteins after APC activation reduces aneuploidy in mouse oocytes. Nat Commun. 2014;5:3444
All references(56)
Other
accession IDs
MGI:2143808

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory