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Fzr1 Gene Detail
Summary
  • Symbol
    Fzr1
  • Name
    fizzy/cell division cycle 20 related 1 (Drosophila)
  • Synonyms
    Cdh1, Fyr
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926790
    NCBI Gene: 56371
Location & Maps
more
  • Sequence Map
    Chr10:81366222-81378516 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12295 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    FZR1, fizzy/cell division cycle 20 related 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FZR1, fizzy/cell division cycle 20 related 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CDC20C, CDH1, FZR, FZR2, HCDH, HCDH1
  • Links
    NCBI Gene ID: 51343
    neXtProt AC: NX_Q9UM11

  • Chr Location
    19p13.3; chr19:3506065-3538539 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 9444
    1 human;1 mouse;1 rat;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: FZR1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    34 phenotypes from 6 alleles in 5 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    47
  • Chemically induced (other)
    1
  • Gene trapped
    40
  • Targeted
    6
  • Genomic Mutations
    1 involving Fzr1
  • Incidental Mutations
Homozygous null mutants die embryonically at around E9.5-E12.5 with poorly developed placentae, no placental giant cells and/or erythroblast deficiency. Homozygous MEFs undergo premature senescence. Heterozygotes exhibit learning/memory defects and/or elevatedspontaneous epithelial tumor incidence.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030386 VEGA Gene Model | MGI Sequence Detail 12295 C57BL/6J ±  kb
transcript OTTMUST00000075264 VEGA | MGI Sequence Detail 3057 Not Applicable  
polypeptide OTTMUSP00000039412 VEGA | MGI Sequence Detail 493 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    19 from dbSNP Build 137
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 12
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:2143808
References
more
  • Summaries
    All 56
    Developmental Gene Expression 7
    Gene Ontology 6
    Phenotypes 28
  • Earliest
    J:59059 Inbal N, et al., The mammalian Fizzy and Fizzy-related genes are regulated at the transcriptional and post-transcriptional levels. FEBS Lett. 1999 Dec 17;463(3):350-4
  • Latest
    J:224438 Serra H, et al., PTEN mediates Notch-dependent stalk cell arrest in angiogenesis. Nat Commun. 2015;6:7935

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory