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Mapk8ip2
Gene Detail
Symbol

Name
ID
Mapk8ip2
mitogen-activated protein kinase 8 interacting protein 2
MGI:1926555
Synonyms
3230402N03Rik, IB2, Jip2, JNK-interacting protein
Feature Type
protein coding gene
Genetic Map
Chromosome 15
44.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:89453913-89464468 bp, + strand
From VEGA annotation of GRCm38

  10556 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8201  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MAPK8IP2
Gene Tree: Mapk8ip2

Human
homologs
MAPK8IP2, mitogen-activated protein kinase 8 interacting protein 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 23542
neXtProt AC: NX_Q13387

Human Synonyms: IB2, IB-2, JIP2, PRKM8IPL

Human Chr (Location): 22q13.33; chr22:50600685-50611551 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Radiation induced(1) Targeted(6)
Genomic Mutations involving Mapk8ip2 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele are smaller in size and exhibit male infertility. Mice homozygous for a different knock-out allele exhibit behavioral and cerebellar transmission deficits.
 
Phenotype Images(2)
Interactions
Mapk8ip2 interacts with 241 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process behavioral fear response, dendrite morphogenesis, ...
Component cytoplasm, intracellular, ...
Function kinesin binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (324)    Tissues (144)    Images (43)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 318
Northern blot 3
Western blot 3
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mapk8ip2    NEW 
Molecular
reagents
All nucleic(13) cDNA(11) Primer pair(1) Other(1)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000032609 (Evidence)
Ensembl Gene Model ENSMUSG00000022619 (Evidence)
Entrez Gene 60597 (Evidence)
DFCI TC1677338, TC1639639, TC1603250, TC1575107
DoTS DT.97370114
NIA Mouse Gene Index U016564
Consensus CDS Project CCDS27752.1
International Mouse Phenotyping Consortium Status Mapk8ip2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032609 VEGA Gene Model | MGI Sequence Detail 10556 C57BL/6J ±  kb
transcript OTTMUST00000081091 VEGA | MGI Sequence Detail 5558 Not Applicable 
polypeptide OTTMUSP00000043322 VEGA | MGI Sequence Detail 830 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(43 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006020 Phosphotyrosine interaction domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000010161 C-Jun-amino-terminal kinase-interacting protein 2
References
(Earliest) J:113792 Yasuda J, et al., The JIP group of mitogen-activated protein kinase scaffold proteins. Mol Cell Biol. 1999 Oct;19(10):7245-54
(Latest) J:214095 Osipovich AB, et al., Insm1 promotes endocrine cell differentiation by modulating the expression of a network of genes that includes Neurog3 and Ripply3. Development. 2014 Aug;141(15):2939-49
All references(46)
Other
accession IDs
MGI:1914671, MGI:2146077, MGI:2146184, MGI:2146319

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory