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Mapk8ip2 Gene Detail
Summary
  • Symbol
    Mapk8ip2
  • Name
    mitogen-activated protein kinase 8 interacting protein 2
  • Synonyms
    3230402N03Rik, IB2, Jip2, JNK-interacting protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926555
    NCBI Gene: 60597
  • Gene Overview
    MyGene.info: MAPK8IP2
Location & Maps
more
  • Sequence Map
    Chr15:89453913-89464468 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10556 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 44.92 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MAPK8IP2, mitogen-activated protein kinase 8 interacting protein 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MAPK8IP2, mitogen-activated protein kinase 8 interacting protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IB2, IB-2, JIP2, PRKM8IPL
  • Links
    NCBI Gene ID: 23542
    neXtProt AC: NX_Q13387

  • Chr Location
    22q13.33; chr22:50600685-50611551 (+)  GRCh38.p2

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Radiation induced
    2
  • Targeted
    6
  • Genomic Mutations
    3 involving Mapk8ip2
  • Incidental Mutations
Mice homozygous for a null allele are smaller in size and exhibit male infertility. Mice homozygous for a different knock-out allele exhibit behavioral and cerebellar transmission deficits.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032609 VEGA Gene Model | MGI Sequence Detail 10556 C57BL/6J ±  kb
transcript OTTMUST00000081091 VEGA | MGI Sequence Detail 5558 Not Applicable  
polypeptide OTTMUSP00000043322 VEGA | MGI Sequence Detail 830 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    43 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 13
    cDNA 11
    Primer pair 1
    Other 1

    Microarray probesets 8
Other
Accession IDs
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MGI:1914671, MGI:2146077, MGI:2146184, MGI:2146319
References
more
  • Summaries
    All 43
    Developmental Gene Expression 6
    Diseases 1
    Gene Ontology 10
    Phenotypes 26
  • Earliest
    J:113792 Yasuda J, et al., The JIP group of mitogen-activated protein kinase scaffold proteins. Mol Cell Biol. 1999 Oct;19(10):7245-54
  • Latest
    J:214095 Osipovich AB, et al., Insm1 promotes endocrine cell differentiation by modulating the expression of a network of genes that includes Neurog3 and Ripply3. Development. 2014 Aug;141(15):2939-49

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory