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Mapk8ip2
Gene Detail
Symbol

Name
ID
Mapk8ip2
mitogen-activated protein kinase 8 interacting protein 2
MGI:1926555
Synonyms
3230402N03Rik, IB2, Jip2, JNK-interacting protein
Feature Type
protein coding gene
Genetic Map
Chromosome 15
44.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:89453913-89464468 bp, + strand
From VEGA annotation of GRCm38

  10556 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8201  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Mapk8ip2

Human
homologs
Human Homolog MAPK8IP2, mitogen-activated protein kinase 8 interacting protein 2
NCBI Gene ID 23542
neXtProt AC  NX_Q13387
Human Synonyms  IB2, IB-2, JIP2, PRKM8IPL
Human Chr (Location)  22q13.33; chr22:50600702-50611551 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Radiation induced(1) Targeted(6)
Genomic Mutations involving Mapk8ip2 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele are smaller in size and exhibit male infertility. Mice homozygous for a different knock-out allele exhibit behavioral and cerebellar transmission deficits.
 
Interactions
Mapk8ip2 interacts with 241 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process behavioral fear response, dendrite morphogenesis, ...
Component cytoplasm, neuronal cell body, ...
Function kinesin binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (324)    Tissues (144)    Images (43)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 318
Northern blot 3
Western blot 3
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) cDNA(11) Primer pair(1) Other(1)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000032609 (Evidence)
Ensembl Gene ModelENSMUSG00000022619 (Evidence)
Entrez Gene60597 (Evidence)
DFCITC1639639, TC1603250, TC1575107, TC1677338
DoTSDT.97370114
NIA Mouse Gene IndexU016564
Consensus CDS ProjectCCDS27752.1
International Mouse Knockout Project StatusMapk8ip2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032609 VEGA Gene Model | MGI Sequence Detail 10556 C57BL/6J ±  kb
transcript OTTMUST00000081091 VEGA | MGI Sequence Detail 5558 Not Applicable 
polypeptide OTTMUSP00000043322 VEGA | MGI Sequence Detail 830 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(2) UniProt(9)
Polymorphisms
SNPs within 2kb(43 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006020 Phosphotyrosine interaction domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000010161 C-Jun-amino-terminal kinase-interacting protein 2
References
(Earliest) J:113792 Yasuda J, et al., The JIP group of mitogen-activated protein kinase scaffold proteins. Mol Cell Biol. 1999 Oct;19(10):7245-54
(Latest) J:176956 Ghosh AS, et al., DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity. J Cell Biol. 2011 Sep 5;194(5):751-64
All references(46)
Other
accession IDs
MGI:1914671, MGI:2146077, MGI:2146184, MGI:2146319

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory