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Lat2 Gene Detail
Summary
  • Symbol
    Lat2
  • Name
    linker for activation of T cells family, member 2
  • Synonyms
    Wbscr15, Wbscr5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926479
    NCBI Gene: 56743
  • Gene Overview
    MyGene.info: LAT2
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:134600022-134615025 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 74.70 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    190 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926479
protein coding gene Chr5:134600022-134619783 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030160
protein coding gene Chr5:139018886-139042527 (-)
A/J MGP_AJ_G0030128
protein coding gene Chr5:133116769-133134587 (-)
AKR/J MGP_AKRJ_G0030061
protein coding gene Chr5:137433545-137450544 (-)
BALB/cJ MGP_BALBcJ_G0030138
protein coding gene Chr5:134463741-134486468 (-)
C3H/HeJ MGP_C3HHeJ_G0029854
protein coding gene Chr5:137983938-138002076 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030591
protein coding gene Chr5:144246414-144272282 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027815
protein coding gene Chr5:127399560-127414175 (-)
CAST/EiJ MGP_CASTEiJ_G0029263
protein coding gene Chr5:137412024-137430722 (-)
CBA/J MGP_CBAJ_G0029824
protein coding gene Chr5:149876697-149902265 (-)
DBA/2J MGP_DBA2J_G0029975
protein coding gene Chr5:133012721-133028782 (-)
FVB/NJ MGP_FVBNJ_G0029930
protein coding gene Chr5:132146244-132161542 (-)
LP/J MGP_LPJ_G0030063
protein coding gene Chr5:139498382-139513591 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029962
protein coding gene Chr5:152938120-152953513 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030631
protein coding gene Chr5:137158384-137175829 (-)
PWK/PhJ MGP_PWKPhJ_G0028978
protein coding gene Chr5:132044221-132060050 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028813
protein coding gene Chr5:134738085-134754723 (-)
WSB/EiJ MGP_WSBEiJ_G0029337
protein coding gene Chr5:137910581-137929240 (-)



Homology
more
  • Human Ortholog
    LAT2, linker for activation of T cells family member 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    LAT2, linker for activation of T cells family member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HSPC046, LAB, NTAL, WBSCR15, WBSCR5, WSCR5
  • Links
    NCBI Gene ID: 7462
    neXtProt AC: NX_Q9GZY6
    UniProt: Q9GZY6

  • Chr Location
    7q11.23; chr7:74209757-74229834 (+)  GRCh38.p7

Human Diseases
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  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 4 alleles in 6 genetic backgrounds
    21 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele have abnormal mast cell physiology and increased anti-nuclear antigen antibody level. Mice homozygous for another null allele show abnormal mast cell physiology, hyperactivated T cells, higher cytokine production, spleenhyperplasia and increased autoantibody level.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040751 Ensembl Gene Model | MGI Sequence Detail 15004 C57BL/6J ±  kb
    transcript ENSMUST00000036362 Ensembl | MGI Sequence Detail 1637 Not Applicable  
    polypeptide ENSMUSP00000046900 Ensembl | MGI Sequence Detail 203 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000009684 linker for activation of T-cells family member 2
    • InterPro Domains
      IPR031428 Linker for activation of T-cells family member 2
    Molecular
    Reagents
    less
    • All nucleic 33
      Genomic 2
      cDNA 30
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1890416, MGI:2141162
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 1
      Diseases 2
      Gene Ontology 4
      Phenotypes 26
    • Earliest
      J:64707 Martindale DW, et al., Comparative genomic sequence analysis of the williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23. Mamm Genome. 2000 Oct;11(10):890-8
    • Latest
      J:237248 Freund J, et al., Activating Receptor Signals Drive Receptor Diversity in Developing Natural Killer Cells. PLoS Biol. 2016 Aug;14(8):e1002526

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory