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Ppp2r1a
Gene Detail
Symbol

Name
ID
Ppp2r1a
protein phosphatase 2, regulatory subunit A, alpha
MGI:1926334
Synonyms
6330556D22Rik, PP2A, PR65, protein phosphatase PP2A
Feature Type
protein coding gene
Genetic Map
Chromosome 17
11.40 cM, cytoband A3.2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:20945311-20965916 bp, + strand
From VEGA annotation of GRCm38

  20606 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68559  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: PPP2R1A
Protein SuperFamily: serine/threonine-protein phosphataser PP2A regulatory subunit A
Gene Tree: Ppp2r1a

Human
homologs
PPP2R1A, protein phosphatase 2, regulatory subunit A, alpha
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5518
neXtProt AC: NX_P30153

Human Synonyms: MRD36, PP2A-Aalpha, PP2AAALPHA, PR65A

Human Chr (Location): 19q13.41; chr19:52189802-52226425 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PPP2R1A

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(3) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted allele that remove exons 5 and 6 exhibit embryonic lethality. Mice heterozygous for this allele exhibit increased benzopyrene-induced lung tumors.
 
Interactions
Ppp2r1a interacts with 112 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process chromosome segregation, female meiotic division, ...
Component chromosome, chromosome, centromeric region, ...
Function antigen binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (225)    Tissues (149)    Images (48)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 208
Western blot 4
RT-PCR 8
cDNA source data(529)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ppp2r1a    NEW 
Molecular
reagents
All nucleic(531) cDNA(529) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000016281 (Evidence)
Ensembl Gene Model ENSMUSG00000007564 (Evidence)
Entrez Gene 51792 (Evidence)
UniGene 294138
DFCI TC1573812
DoTS DT.55100301, DT.94251305, DT.91397660
PDB 2IAE, 3FGA, 2PF4
Consensus CDS Project CCDS28432.1
International Mouse Phenotyping Consortium Status Ppp2r1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016281 VEGA Gene Model | MGI Sequence Detail 20606 C57BL/6J ±  kb
transcript OTTMUST00000039080 VEGA | MGI Sequence Detail 2410 Not Applicable 
polypeptide OTTMUSP00000017454 VEGA | MGI Sequence Detail 589 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(62 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR000357 HEAT
InterPro IPR021133 HEAT, type 2
Protein Ontology PR:000013134 serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
References
(Earliest) J:11704 Matsuzawa S, et al., Increase in potential activities of protein phosphatases PP1 and PP2A in lymphoid tissues of autoimmune MRL/MpJ-lpr/lpr mice. J Biochem. 1992 Apr;111(4):472-7
(Latest) J:213800 Hu MW, et al., Scaffold subunit Aalpha of PP2A is essential for female meiosis and fertility in mice. Biol Reprod. 2014 Jul;91(1):19
All references(56)
Other
accession IDs
MGI:1923432

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory