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Irgm2 Gene Detail
Summary
  • Symbol
    Irgm2
  • Name
    immunity-related GTPase family M member 2
  • Synonyms
    Gtpi, Iigp2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926262
    NCBI Gene: 54396
  • Gene Overview
    MyGene.info: IRGM
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr11:58214977-58222783 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 36.07 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    119 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926262
protein coding gene Chr11:58199618-58222783 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018346
protein coding gene Chr11:57879087-57906842 (+)
A/J MGP_AJ_G0018316
protein coding gene Chr11:55668893-55710011 (+)
AKR/J MGP_AKRJ_G0018285
protein coding gene Chr11:57513956-57541668 (+)
BALB/cJ MGP_BALBcJ_G0018287
protein coding gene Chr11:56026748-56050655 (+)
C3H/HeJ MGP_C3HHeJ_G0018098
protein coding gene Chr11:57452052-57476352 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018738
protein coding gene Chr11:59667295-59689101 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016388
protein coding gene Chr11:53053423-53060365 (+)
CAST/EiJ MGP_CASTEiJ_G0017663
protein coding gene Chr11:57562395-57570165 (+)
CBA/J MGP_CBAJ_G0018073
protein coding gene Chr11:62411578-62441414 (+)
DBA/2J MGP_DBA2J_G0018182
protein coding gene Chr11:55350426-55358737 (+)
FVB/NJ MGP_FVBNJ_G0018173
protein coding gene Chr11:55047826-55051143 (+)
LP/J MGP_LPJ_G0018257
protein coding gene Chr11:58412427-58438531 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018199
protein coding gene Chr11:63523934-63555179 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018781
protein coding gene Chr11:57557852-57584404 (+)
PWK/PhJ MGP_PWKPhJ_G0017435
protein coding gene Chr11:55955440-55964110 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017230
protein coding gene Chr11:57454739-57462572 (+)
WSB/EiJ MGP_WSBEiJ_G0017710
protein coding gene Chr11:57187729-57216415 (+)



Homology
more
  • Human Ortholog
    IRGM, immunity related GTPase M
  • Vertebrate Orthologs
    7
  • Human Ortholog
    IRGM, immunity related GTPase M
    Orthology source: HomoloGene
  • Synonyms
    IFI1, IRGM1, LRG47, LRG-47
  • Links
    NCBI Gene ID: 345611
    neXtProt AC: NX_A1A4Y4
    UniProt: A1A4Y4

  • Chr Location
    5q33.1; chr5:150846523-150902402 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human IRGM associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 54396 NCBI Gene Model | MGI Sequence Detail 7807 C57BL/6J ±  kb
transcript NM_019440 RefSeq | MGI Sequence Detail 3537 C57BL/6  
polypeptide NP_062313 RefSeq | MGI Sequence Detail 395 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • InterPro Domains
    IPR007743 Immunity-related GTPases-like
    IPR030385 IRG-type guanine nucleotide-binding (G) domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
less
  • All nucleic 61
    cDNA 61

    Microarray probesets 3
Other
Accession IDs
less
MGI:2144195
References
more
  • Summaries
    All 35
    Gene Ontology 9
    Phenotypes 7
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:233076 Langlais D, et al., The macrophage IRF8/IRF1 regulome is required for protection against infections and is associated with chronic inflammation. J Exp Med. 2016 Apr 4;213(4):585-603

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory