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Irgm2 Gene Detail
Summary
  • Symbol
    Irgm2
  • Name
    immunity-related GTPase family M member 2
  • Synonyms
    Gtpi, Iigp2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926262
    NCBI Gene: 54396
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:58105803-58113609 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 36.07 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    119 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926262
protein coding gene Chr11:58090444-58113609 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018346
protein coding gene Chr11:57879087-57906842 (+)
A/J MGP_AJ_G0018316
protein coding gene Chr11:55668893-55710011 (+)
AKR/J MGP_AKRJ_G0018285
protein coding gene Chr11:57513956-57541668 (+)
BALB/cJ MGP_BALBcJ_G0018287
protein coding gene Chr11:56026748-56050655 (+)
C3H/HeJ MGP_C3HHeJ_G0018098
protein coding gene Chr11:57452052-57476352 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018738
protein coding gene Chr11:59667295-59689101 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016388
protein coding gene Chr11:53053423-53060365 (+)
CAST/EiJ MGP_CASTEiJ_G0017663
protein coding gene Chr11:57562395-57570165 (+)
CBA/J MGP_CBAJ_G0018073
protein coding gene Chr11:62411578-62441414 (+)
DBA/2J MGP_DBA2J_G0018182
protein coding gene Chr11:55350426-55358737 (+)
FVB/NJ MGP_FVBNJ_G0018173
protein coding gene Chr11:55047826-55051143 (+)
LP/J MGP_LPJ_G0018257
protein coding gene Chr11:58412427-58438531 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018199
protein coding gene Chr11:63523934-63555179 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018781
protein coding gene Chr11:57557852-57584404 (+)
PWK/PhJ MGP_PWKPhJ_G0017435
protein coding gene Chr11:55955440-55964110 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017230
protein coding gene Chr11:57454739-57462572 (+)
WSB/EiJ MGP_WSBEiJ_G0017710
protein coding gene Chr11:57187729-57216415 (+)



Homology
more
  • Human Ortholog
    IRGM, immunity related GTPase M
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IRGM, immunity related GTPase M
  • Synonyms
    IBD19, IFI1, IRGM1, LRG47, LRG-47
  • Links
    NCBI Gene ID: 345611
    neXtProt AC: NX_A1A4Y4
    UniProt: A1A4Y4

  • Chr Location
    5q33.1; chr5:150846521-150902402 (+)  GRCh38

Human Diseases
more
  • Diseases
    2 with human IRGM associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit impaired cell-autonomous Toxoplasma killing.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 54396 NCBI Gene Model | MGI Sequence Detail 7807 C57BL/6J ±  kb
    transcript NM_019440 RefSeq | MGI Sequence Detail 3537 C57BL/6  
    polypeptide A0A140LIF8 UniProt | EBI | MGI Sequence Detail 395 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • EC
    • InterPro Domains
      IPR007743 Immunity-related GTPases-like
      IPR030385 IRG-type guanine nucleotide-binding (G) domain
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 61
      cDNA 61

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2144195
    References
    more
    • Summaries
      All 43
      Gene Ontology 10
      Phenotypes 13
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:333980 Christgen S, et al., The IFN-inducible GTPase IRGB10 regulates viral replication and inflammasome activation during influenza A virus infection in mice. Eur J Immunol. 2022 Feb;52(2):285-296

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory