Irgm2 MGI Mouse Gene Detail - MGI:1926262 - immunity-related GTPase family M member 2

Symbol

Irgm2
Name

immunity-related GTPase family M member 2
Synonyms

Gtpi, Iigp2

Feature Type

protein coding gene
IDs

MGI:1926262
NCBI Gene: 54396
Alliance

genome feature page
Transcription Start Sites

7 TSS

Sequence Map

Chr11:58105803-58113609 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 36.07 cM
Mapping Data

1 experiment

SNPs within 2kb

119 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1926262	protein coding gene	Chr11:58090444-58113609 (+)
129S1/SvImJ	ENSMUSG00200035557	protein coding gene	Chr11:55089565-55112790 (+)
A/J	ENSMUSG00195036498	protein coding gene	Chr11:55023668-55046891 (+)
AKR/J	ENSMUSG00220038788	protein coding gene	Chr11:55185704-55208918 (+)
BALB/cJ	ENSMUSG00180048406	protein coding gene	Chr11:55105717-55128935 (+)
C3H/HeJ	ENSMUSG00175047791	protein coding gene	Chr11:55058957-55082175 (+)
C57BL/6NJ	ENSMUSG00215039133	protein coding gene	Chr11:54880445-54903616 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016388	protein coding gene	Chr11:53053423-53060365 (+)
CAST/EiJ	ENSTCUG00005037754	protein coding gene	Chr11:54597932-54621012 (+)
CBA/J	ENSMUSG00210028367	protein coding gene	Chr11:54910348-54933570 (+)
DBA/2J	ENSMUSG00185037924	protein coding gene	Chr11:55095220-55118435 (+)
FVB/NJ	ENSMUSG00205042301	protein coding gene	Chr11:54963113-54986328 (+)
JF1/MsJ	ENSUMUG00000024224	protein coding gene	Chr11:55443163-55466333 (+)
LP/J	ENSMUSG00230046910	protein coding gene	Chr11:56295829-56319373 (+)
NOD/ShiLtJ	ENSMUSG00190031306	protein coding gene	Chr11:55149196-55172407 (+)
NZO/HlLtJ	ENSMUSG00225032197	protein coding gene	Chr11:58311511-58335053 (+)
PWK/PhJ	ENSLUMG00010026494	protein coding gene	Chr11:54917626-54925432 (+)
SPRET/EiJ	ENSMSPG00010028619	protein coding gene	Chr11:55688203-55711370 (+)
WSB/EiJ	ENSIUOG00005030489	protein coding gene	Chr11:54951800-54974990 (+)

Human Ortholog

IRGM, immunity related GTPase M

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IRGM, immunity related GTPase M
Synonyms

IBD19, IFI1, IRGM1, LRG-47, LRG47
Links

HGNC:29597

NCBI Gene ID: 345611

UniProt: A1A4Y4
Chr Location

5q33.1; chr5:150846521-150902402 (+) GRCh38

MGI Vertebrate Homology

Irgm2 stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: IRGM
Gene Tree

Irgm2

Diseases

2 with human IRGM associations

				Human Disease	Mouse Models
				inflammatory bowel disease 19 IDs inflammatory bowel disease 19 DOID:0110890 MESH:C567372 OMIM:612278
				tuberculosis IDs tuberculosis DOID:399 DOID:10096 DOID:12688 DOID:12691 DOID:415 DOID:9901 DOID:9902 MESH:D014375 UMLS_CUI:C0041295

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

6
Targeted

2
Genomic Mutations

1 involving Irgm2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit impaired cell-autonomous Toxoplasma killing.

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All GO Annotations

79
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

61

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

45
RefSeq

8
UniProt

2
CCDS

CCDS48803.1

Ensembl

ENSMUSG00000069874 (Evidence)
NCBI Gene

54396

			Length	Strain/Species	Flank
genomic	54396	NCBI Gene Model \| MGI Sequence Detail	7807	C57BL/6J	± kb
transcript	NM_001436172	RefSeq \| MGI Sequence Detail	3525	C57BL/6
polypeptide	A0A140LIF8	UniProt \| EBI \| MGI Sequence Detail	395	Not Applicable

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UniProt

2 Sequences
EC

3.6.5.-
InterPro Domains

IPR051515 Immunity-related GTPase

IPR007743 Immunity-related GTPases-like

IPR030385 IRG-type guanine nucleotide-binding (G) domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase
GlyGen

A0A140LIF8 1 site, 1 N-linked glycan (1 site)

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All nucleic 61

cDNA 61

Microarray probesets 3

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MGI:2144195

Summaries

All 47

Gene Ontology 14

Phenotypes 16
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:361381 Dockterman J, et al., Irgm proteins attenuate inflammatory disease in mouse models of genital Chlamydia infection. mBio. 2024 Apr 10;15(4):e0030324

TSS for Irgm2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101708	Chr11:58111005-58111016 (+)	5,208 bp
Tssr101709	Chr11:58111307-58111336 (+)	5,519 bp
Tssr101710	Chr11:58111342-58111354 (+)	5,545 bp
Tssr101711	Chr11:58111503-58111540 (+)	5,719 bp
Tssr101712	Chr11:58111557-58111581 (+)	5,766 bp
Tssr101713	Chr11:58111875-58111900 (+)	6,085 bp
Tssr101714	Chr11:58111924-58111941 (+)	6,130 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24