Sequence Detail

ID/Version

A0A140LIF8 Q3U635 Q9Z1M2 E9PVI2 Q3TNE5 Q3TAN6 (UniProt | EBI)

Last sequence update: 2023-05-03
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Immunity-related GTPase family M protein 2 {ECO:0000305}; EC=3.6.5.- {ECO:0000269|PubMed:34078740};AltName: Full=Interferon-inducible GTPase 2 {ECO:0000303|PubMed:17641048};

Provider

SWISS-PROT

Sequence

Polypeptide 395 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Irgm2	immunity-related GTPase family M member 2	62	96	1	14

Sequence references in MGI

J:64689 Boehm U, et al., Two families of GTPases dominate the complex cellular response to IFN-gamma. J Immunol. 1998 Dec 15;161(12):6715-23
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:150323 Miyairi I, et al., The p47 GTPases Iigp2 and Irgb10 regulate innate immunity and inflammation to murine Chlamydia psittaci infection. J Immunol. 2007 Aug 1;179(3):1814-24
J:301384 Finethy R, et al., Dynamin-related Irgm proteins modulate LPS-induced caspase-11 activation and septic shock. EMBO Rep. 2020 Nov 5;21(11):e50830
J:301547 Eren E, et al., Irgm2 and Gate-16 cooperatively dampen Gram-negative bacteria-induced caspase-11 response. EMBO Rep. 2020 Nov 5;21(11):e50829
J:308470 Pradipta A, et al., Cell-autonomous Toxoplasma killing program requires Irgm2 but not its microbe vacuolar localization. Life Sci Alliance. 2021 Jul;4(7)
J:333017 Dockterman J, et al., Murine Irgm Paralogs Regulate Nonredundant Functions To Execute Host Defense to Toxoplasma gondii. Infect Immun. 2021 Oct 15;89(11):e0020221