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Cysltr1 Gene Detail
Summary
  • Symbol
    Cysltr1
  • Name
    cysteinyl leukotriene receptor 1
  • Synonyms
    CysLT1R, cysteinyl leukotriene 1 receptor, leukotriene D4 receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926218
    NCBI Gene: 58861
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:105617952-105647285 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 47.36 cM, cytoband D
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    103 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926218
 protein coding gene ChrX:105617952-105647329 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036007
 protein coding gene ChrX:103408239-103438198 (-)
A/J MGP_AJ_G0035986
 protein coding gene ChrX:103219842-103254500 (-)
AKR/J MGP_AKRJ_G0035905
 protein coding gene ChrX:106492526-106522575 (-)
BALB/cJ MGP_BALBcJ_G0035977
 protein coding gene ChrX:102015355-102044885 (-)
C3H/HeJ MGP_C3HHeJ_G0035683
 protein coding gene ChrX:103854132-103884277 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036503
 protein coding gene ChrX:106395881-106427421 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033331
 protein coding gene ChrX:100598405-100627606 (-)
CAST/EiJ MGP_CASTEiJ_G0034970
 protein coding gene ChrX:88003915-88035597 (-)
CBA/J MGP_CBAJ_G0035659
 protein coding gene ChrX:109722478-109753707 (-)
DBA/2J MGP_DBA2J_G0035813
 protein coding gene ChrX:102475586-102505590 (-)
FVB/NJ MGP_FVBNJ_G0035753
 protein coding gene ChrX:101803431-101832543 (-)
LP/J MGP_LPJ_G0035905
 protein coding gene ChrX:104336980-104370627 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035785
 protein coding gene ChrX:114413727-114447787 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036530
 protein coding gene ChrX:103026745-103055867 (-)
PWK/PhJ MGP_PWKPhJ_G0034666
 protein coding gene ChrX:85541890-85571761 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034495
 protein coding gene ChrX:88770091-88799284 (-)
WSB/EiJ MGP_WSBEiJ_G0035108
 protein coding gene ChrX:101747297-101777936 (-)



Homology
more
  • Human Ortholog
    CYSLTR1, cysteinyl leukotriene receptor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYSLTR1, cysteinyl leukotriene receptor 1
  • Synonyms
    CYSLT1, CYSLT1R, CYSLTR, HMTMF81
  • Links
    NCBI Gene ID: 10800
    neXtProt AC: NX_Q9Y271
    UniProt: Q9Y271

  • Chr Location
    Xq21.1; chrX:78271468-78327691 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human CYSLTR1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gen develop normally and both sexes are fertile. However, they display abnormalities in vascular permeability associated with inflammation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    749
  • Tissues
    29
  • cDNA Data
    10
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000052821 Ensembl Gene Model | MGI Sequence Detail 29334 C57BL/6J ±  kb
    transcript ENSMUST00000113480 Ensembl | MGI Sequence Detail 5142 Not Applicable  
    polypeptide ENSMUSP00000109108 Ensembl | MGI Sequence Detail 352 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      Genomic 1
      cDNA 10

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2148041
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 1
      Gene Ontology 8
      Phenotypes 32
    • Earliest
      J:67843 Maekawa A, et al., Identification in mice of two isoforms of the cysteinyl leukotriene 1 receptor that result from alternative splicing. Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2256-61
    • Latest
      J:334239 Liu X, et al., Deficiency of astrocyte CysLT(1)R ameliorates depression-like behaviors in mice by modulating glutamate synaptic transmission. Neurobiol Dis. 2022 Nov 10;175:105922
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    04/16/2024
    MGI 6.23     		The Jackson Laboratory