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Cysltr1 Gene Detail
Summary
  • Symbol
    Cysltr1
  • Name
    cysteinyl leukotriene receptor 1
  • Synonyms
    CysLT1R, cysteinyl leukotriene 1 receptor, leukotriene D4 receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926218
    NCBI Gene: 58861
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:106576509-106603679 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 47.36 cM, cytoband D
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    100 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926218
protein coding gene ChrX:106574346-106603679 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036007
protein coding gene ChrX:103408239-103438198 (-)
A/J MGP_AJ_G0035986
protein coding gene ChrX:103219842-103254500 (-)
AKR/J MGP_AKRJ_G0035905
protein coding gene ChrX:106492526-106522575 (-)
BALB/cJ MGP_BALBcJ_G0035977
protein coding gene ChrX:102015355-102044885 (-)
C3H/HeJ MGP_C3HHeJ_G0035683
protein coding gene ChrX:103854132-103884277 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036503
protein coding gene ChrX:106395881-106427421 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033331
protein coding gene ChrX:100598405-100627606 (-)
CAST/EiJ MGP_CASTEiJ_G0034970
protein coding gene ChrX:88003915-88035597 (-)
CBA/J MGP_CBAJ_G0035659
protein coding gene ChrX:109722478-109753707 (-)
DBA/2J MGP_DBA2J_G0035813
protein coding gene ChrX:102475586-102505590 (-)
FVB/NJ MGP_FVBNJ_G0035753
protein coding gene ChrX:101803431-101832543 (-)
LP/J MGP_LPJ_G0035905
protein coding gene ChrX:104336980-104370627 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035785
protein coding gene ChrX:114413727-114447787 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036530
protein coding gene ChrX:103026745-103055867 (-)
PWK/PhJ MGP_PWKPhJ_G0034666
protein coding gene ChrX:85541890-85571761 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034495
protein coding gene ChrX:88770091-88799284 (-)
WSB/EiJ MGP_WSBEiJ_G0035108
protein coding gene ChrX:101747297-101777936 (-)



Homology
more
  • Human Ortholog
    CYSLTR1, cysteinyl leukotriene receptor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CYSLTR1, cysteinyl leukotriene receptor 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CYSLT1, CYSLT1R, CYSLTR, HMTMF81
  • Links
    NCBI Gene ID: 10800
    neXtProt AC: NX_Q9Y271
    UniProt: Q9Y271

  • Chr Location
    Xq21.1; chrX:78271468-78327691 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gen develop normally and both sexes are fertile. However, they display abnormalities in vascular permeability associated with inflammation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 58861 NCBI Gene Model | MGI Sequence Detail 27171 C57BL/6J ±  kb
    transcript NM_021476 RefSeq | MGI Sequence Detail 2979 C57BL/6  
    polypeptide Q99JA4 UniProt | EBI | MGI Sequence Detail 352 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      Genomic 1
      cDNA 10

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2148041
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 1
      Gene Ontology 9
      Phenotypes 18
    • Earliest
      J:67843 Maekawa A, et al., Identification in mice of two isoforms of the cysteinyl leukotriene 1 receptor that result from alternative splicing. Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2256-61
    • Latest
      J:250033 Lund SJ, et al., Leukotriene C4 Potentiates IL-33-Induced Group 2 Innate Lymphoid Cell Activation and Lung Inflammation. J Immunol. 2017 Aug 1;199(3):1096-1104

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory