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Med12 Gene Detail
Summary
  • Symbol
    Med12
  • Name
    mediator complex subunit 12
  • Synonyms
    Mopa, OPA-1, Tnrc11, Trap230
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926212
    NCBI Gene: 59024
  • Gene Overview
    MyGene.info: MED12
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:101274030-101297465 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 43.91 cM, cytoband C2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    27 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926212
protein coding gene ChrX:101274030-101298934 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035957
protein coding gene ChrX:97774276-97797711 (+)
A/J MGP_AJ_G0035942
protein coding gene ChrX:97779052-97802514 (+)
AKR/J MGP_AKRJ_G0035858
protein coding gene ChrX:100580462-100603678 (+)
BALB/cJ MGP_BALBcJ_G0035925
protein coding gene ChrX:96518396-96541831 (+)
C3H/HeJ MGP_C3HHeJ_G0035634
protein coding gene ChrX:98180607-98204042 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036454
protein coding gene ChrX:100680914-100705298 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033284
protein coding gene ChrX:95533005-95556635 (+)
CAST/EiJ MGP_CASTEiJ_G0034921
protein coding gene ChrX:82484784-82508283 (+)
CBA/J MGP_CBAJ_G0035609
protein coding gene ChrX:103795638-103819073 (+)
DBA/2J MGP_DBA2J_G0035763
protein coding gene ChrX:96994184-97019217 (+)
FVB/NJ MGP_FVBNJ_G0035701
protein coding gene ChrX:96377744-96401410 (+)
LP/J MGP_LPJ_G0035853
protein coding gene ChrX:98736043-98759474 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035736
protein coding gene ChrX:108347452-108371649 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036481
protein coding gene ChrX:97466533-97491972 (+)
PWK/PhJ MGP_PWKPhJ_G0034620
protein coding gene ChrX:80091404-80115396 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034448
protein coding gene ChrX:83389797-83413581 (+)
WSB/EiJ MGP_WSBEiJ_G0035060
protein coding gene ChrX:96172189-96196924 (+)



Homology
more
  • Human Ortholog
    MED12, mediator complex subunit 12
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MED12, mediator complex subunit 12
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARC240, CAGH45, FGS1, HOPA, MED12S, OHDOX, OKS, OPA1, TNRC11, TRAP230
  • Links
    NCBI Gene ID: 9968
    neXtProt AC: NX_Q93074
    UniProt: Q93074

  • Chr Location
    Xq13.1; chrX:71118556-71142454 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human MED12 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 3 alleles in 3 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Male chimeras hemizygous for a null allele arrest at E7.5 and lack anterior visceral endoderm. Male chimeras hemizygous for a hypomorphic allele die at E10.5 showing failure of neural crest cell migration and severe defects in neural tube closure, axis elongation, somitogenesis and heart formation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000079487 Ensembl Gene Model | MGI Sequence Detail 23436 C57BL/6J ±  kb
    transcript ENSMUST00000087948 Ensembl | MGI Sequence Detail 6809 Not Applicable  
    polypeptide ENSMUSP00000085260 Ensembl | MGI Sequence Detail 2190 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000010282 mediator of RNA polymerase II transcription subunit 12
    • InterPro Domains
      IPR019035 Mediator complex, subunit Med12
      IPR021989 Mediator complex, subunit Med12, catenin-binding
      IPR021990 Mediator complex, subunit Med12, LCEWAV-domain
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 7
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 4
      Gene Ontology 14
      Phenotypes 8
    • Earliest
      J:65049 Duboule D, et al., DNA sequences homologous to the Drosophila opa repeat are present in murine mRNAs that are differentially expressed in fetuses and adult tissues. Mol Cell Biol. 1987 May;7(5):2003-6
    • Latest
      J:239012 Aranda-Orgilles B, et al., MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis. Cell Stem Cell. 2016 Dec 01;19(6):784-799

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory