Med12
Gene Detail

Symbol Name ID

Med12 mediator of RNA polymerase II transcription, subunit 12 homolog (yeast) MGI:1926212

Synonyms

Mopa, OPA-1, Tnrc11, Trap230

Feature Type

protein coding gene

Genetic Map

Chromosome X

43.91 cM, cytoband C2
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

ChrX:101274030-101297465 bp, + strand From VEGA annotation of GRCm38   23436 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68441  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: mediator of RNA polymerase II transcription, subunits 12/12L, metazoan type
Gene Tree: Med12

Human homologs

Human Homolog		MED12, mediator complex subunit 12
NCBI Gene ID		9968
neXtProt AC		NX_Q93074
Human Synonyms		ARC240, CAGH45, FGS1, HOPA, MED12S, OKS, OPA1, TNRC11, TRAP230
Human Chr (Location)		Xq13; chrX:70338406-70362304 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human MED12

Alleles and phenotypes

All alleles(6) : Targeted(6)

Gene Ontology (GO) classifications

All GO classifications: (27 annotations)

Process	androgen receptor signaling pathway, axis elongation involved in somitogenesis, ...
Component	mediator complex, nucleus
Function	beta-catenin binding, chromatin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
cDNA source data(94)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(96) cDNA(95) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000018212 (Evidence)
Ensembl Gene Model	ENSMUSG00000079487 (Evidence)
Entrez Gene	59024 (Evidence)
UniGene	20873
DFCI	TC1579843, TC1585646, TC1597230, TC1628167
DoTS	DT.101156991, DT.101379431, DT.111029041
NIA Mouse Gene Index	U043774
Consensus CDS Project	CCDS41078.1
International Mouse Knockout Project Status	Med12

Sequences

Length	Strain/Species
genomic	OTTMUSG00000018212	VEGA Gene Model | MGI Sequence Detail	23436	C57BL/6J
transcript	OTTMUST00000043990	VEGA | MGI Sequence Detail	6809	Not Applicable
polypeptide	OTTMUSP00000019751	VEGA | MGI Sequence Detail	2190	Not Applicable

All sequences(54) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(25 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR019035	Mediator complex, subunit Med12
InterPro	IPR021989	Mediator complex, subunit Med12, catenin-binding
InterPro	IPR021990	Mediator complex, subunit Med12, LCEWAV-domain
Protein Ontology	PR:000010282	mediator of RNA polymerase II transcription subunit 12

References

(Earliest) J:65049 Duboule D, et al., DNA sequences homologous to the Drosophila opa repeat are present in murine mRNAs that are differentially expressed in fetuses and adult tissues. Mol Cell Biol. 1987 May;7(5):2003-6
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(37)