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Gene Detail
mediator complex subunit 12
Synonyms Mopa, OPA-1, Tnrc11, Trap230
Feature Type protein coding gene
Genetic Map
Chromosome X
43.91 cM, cytoband C2
Detailed Genetic Map ± 1 cM

Mapping data(1)
Sequence Map
ChrX:101274030-101297465 bp, + strand
From VEGA annotation of GRCm38

  23436 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:68441  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: mediator of RNA polymerase II transcription, subunits 12/12L, metazoan type
Gene Tree: Med12

Human Homolog MED12, mediator complex subunit 12
NCBI Gene ID 9968
neXtProt AC  NX_Q93074
Human Synonyms  ARC240, CAGH45, FGS1, HOPA, MED12S, OHDOX, OKS, OPA1, TNRC11, TRAP230
Human Chr (Location)  Xq13; chrX:71118556-71142454 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human MED12
alleles, and
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from APF )
Male chimeras hemizygous for a null allele arrest at E7.5 and lack anterior visceral endoderm. Male chimeras hemizygous for a hypomorphic allele die at E10.5 showing failure of neural crest cell migration and severe defects in neural tube closure, axis elongation, somitogenesis and heart formation.
Med12 interacts with 161 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
All GO classifications: (36 annotations)
Process androgen receptor signaling pathway, axis elongation involved in somitogenesis, ...
Component mediator complex, membrane, ...
Function beta-catenin binding, chromatin binding, ...
External Resources: FuncBase
Literature Summary: (2 records)
cDNA source data(5)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
All nucleic(7) cDNA(6) Primer pair(1)
Microarray probesets(3)
Other database
VEGA Gene ModelOTTMUSG00000018212 (Evidence)
Ensembl Gene ModelENSMUSG00000079487 (Evidence)
Entrez Gene59024 (Evidence)
DFCITC1579843, TC1585646, TC1597230, TC1628167
DoTSDT.101156991, DT.101379431, DT.111029041
NIA Mouse Gene IndexU043774
Consensus CDS ProjectCCDS41078.1
International Mouse Knockout Project StatusMed12
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018212 VEGA Gene Model | MGI Sequence Detail 23436 C57BL/6J ±  kb
transcript OTTMUST00000043990 VEGA | MGI Sequence Detail 6809 Not Applicable 
polypeptide OTTMUSP00000019751 VEGA | MGI Sequence Detail 2190 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(2) UniProt(5)
Polymorphisms SNPs within 2kb(27 from dbSNP Build 137)
InterPro IPR019035 Mediator complex, subunit Med12
InterPro IPR021989 Mediator complex, subunit Med12, catenin-binding
InterPro IPR021990 Mediator complex, subunit Med12, LCEWAV-domain
Protein Ontology PR:000010282 mediator of RNA polymerase II transcription subunit 12
References (Earliest) J:65049 Duboule D, et al., DNA sequences homologous to the Drosophila opa repeat are present in murine mRNAs that are differentially expressed in fetuses and adult tissues. Mol Cell Biol. 1987 May;7(5):2003-6
(Latest) J:196667 Vogl MR, et al., Sox10 cooperates with the mediator subunit 12 during terminal differentiation of myelinating glia. J Neurosci. 2013 Apr 10;33(15):6679-90
All references(38)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory