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Arid1b Gene Detail
Summary
  • Symbol
    Arid1b
  • Name
    AT rich interactive domain 1B (SWI-like)
  • Synonyms
    9330189K18Rik, B230217J03Rik, mKIAA1235
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926129
    NCBI Gene: 239985
  • Gene Overview
    MyGene.info: ARID1B
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:4994332-5347656 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 2.83 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2306 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926129
protein coding gene Chr17:4994191-5347656 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023102
protein coding gene Chr17:2080171-2449188 (+)
A/J MGP_AJ_G0023073
protein coding gene Chr17:2061951-2415510 (+)
AKR/J MGP_AKRJ_G0023039
protein coding gene Chr17:2095070-2456245 (+)
BALB/cJ MGP_BALBcJ_G0023075
protein coding gene Chr17:2035423-2385632 (+)
C3H/HeJ MGP_C3HHeJ_G0022834
protein coding gene Chr17:2136573-2498143 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023521
protein coding gene Chr17:2238826-2608465 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021021
protein coding gene Chr17:1883084-2237734 (+)
CAST/EiJ MGP_CASTEiJ_G0022353
protein coding gene Chr17:2150398-2511728 (+)
CBA/J MGP_CBAJ_G0022802
protein coding gene Chr17:2310048-2698982 (+)
DBA/2J MGP_DBA2J_G0022937
protein coding gene Chr17:1926120-2277039 (+)
FVB/NJ MGP_FVBNJ_G0022911
protein coding gene Chr17:1968914-2322459 (+)
LP/J MGP_LPJ_G0023006
protein coding gene Chr17:2206524-2573407 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022932
protein coding gene Chr17:2215235-2585185 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023538
protein coding gene Chr17:2131458-2498881 (+)
PWK/PhJ MGP_PWKPhJ_G0022098
protein coding gene Chr17:1981430-2351683 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021926
protein coding gene Chr17:2079335-2442421 (+)
WSB/EiJ MGP_WSBEiJ_G0022404
protein coding gene Chr17:2085388-2455138 (+)



Homology
more
  • Human Ortholog
    ARID1B, AT-rich interaction domain 1B
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ARID1B, AT-rich interaction domain 1B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    6A3-5, BAF250B, BRIGHT, CSS1, DAN15, ELD/OSA1, MRD12, OSA2, P250R
  • Links
    NCBI Gene ID: 57492
    neXtProt AC: NX_Q8NFD5
    UniProt: Q8NFD5

  • Chr Location
    6q25.3; chr6:156777847-157210779 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Arid1b mouse models; 1 with human ARID1B associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die perinatally. Heterozygous null mice exhibit increased self-grooming, altered vocalization and response to social novelty, anxiety-like behavior, neuroanatomical anomalies, decreased plasma IGF1 levels, muscle weakness, and growth impairment.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000069729 Ensembl Gene Model | MGI Sequence Detail 353325 C57BL/6J ±  kb
    transcript ENSMUST00000232180 Ensembl | MGI Sequence Detail 7309 Not Applicable  
    polypeptide ENSMUSP00000156119 Ensembl | MGI Sequence Detail 2296 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 61
      cDNA 60
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1924763, MGI:2146926
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 9
      Phenotypes 15
    • Earliest
      J:50247 Bergstrom RA, et al., Deletion mapping of the head tilt (het) gene in mice: a vestibular mutation causing specific absence of otoliths. Genetics. 1998 Oct;150(2):815-22
    • Latest
      J:264370 Sima J, et al., Eda-activated RelB recruits an SWI/SNF (BAF) chromatin-remodeling complex and initiates gene transcription in skin appendage formation. Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):8173-8178

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory