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Abraxas2 Gene Detail
Summary
  • Symbol
    Abraxas2
  • Name
    BRISC complex subunit
  • Synonyms
    C430003P19Rik, Fam175b, KIAA0157
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926116
    NCBI Gene: 109359
  • Gene Overview
    MyGene.info: ABRAXAS2
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:132859225-132885111 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 76.32 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    112 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926116
protein coding gene Chr7:132859225-132885114 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033117
protein coding gene Chr7:137569589-137595882 (+)
A/J MGP_AJ_G0033099
protein coding gene Chr7:133779379-133805086 (+)
AKR/J MGP_AKRJ_G0033031
protein coding gene Chr7:137342320-137370644 (+)
BALB/cJ MGP_BALBcJ_G0033100
protein coding gene Chr7:133462061-133488303 (+)
C3H/HeJ MGP_C3HHeJ_G0032814
protein coding gene Chr7:137181884-137208672 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033611
protein coding gene Chr7:142802254-142829387 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030582
protein coding gene Chr7:135059940-135086689 (+)
CAST/EiJ MGP_CASTEiJ_G0032143
protein coding gene Chr7:129047022-129122281 (+)
CBA/J MGP_CBAJ_G0032787
protein coding gene Chr7:147638380-147671687 (+)
DBA/2J MGP_DBA2J_G0032939
protein coding gene Chr7:131792251-131821680 (+)
FVB/NJ MGP_FVBNJ_G0032892
protein coding gene Chr7:131631806-131657369 (+)
LP/J MGP_LPJ_G0033033
protein coding gene Chr7:139087454-139113982 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032924
protein coding gene Chr7:148557103-148583600 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033631
protein coding gene Chr7:136338235-136370496 (+)
PWK/PhJ MGP_PWKPhJ_G0031849
protein coding gene Chr7:124769116-124841903 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031696
protein coding gene Chr7:123123498-123149394 (+)
WSB/EiJ MGP_WSBEiJ_G0032255
protein coding gene Chr7:137241089-137267780 (+)



Homology
more
  • Human Ortholog
    ABRAXAS2, abraxas 2, BRISC complex subunit
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ABRAXAS2, abraxas 2, BRISC complex subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ABRO1, FAM175B, KIAA0157
  • Links
    NCBI Gene ID: 23172
    neXtProt AC: NX_Q15018
    UniProt: Q15018

  • Chr Location
    10q26.13; chr10:124801785-124836670 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030965 Ensembl Gene Model | MGI Sequence Detail 25887 C57BL/6J ±  kb
transcript ENSMUST00000084497 Ensembl | MGI Sequence Detail 2892 Not Applicable  
polypeptide ENSMUSP00000081541 Ensembl | MGI Sequence Detail 424 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 3
Other
Accession IDs
less
MGI:2141844, MGI:2142066
References
more
  • Summaries
    All 32
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:245949 Xu S, et al., Abro1 maintains genome stability and limits replication stress by protecting replication fork stability. Genes Dev. 2017 Jul 15;31(14):1469-1482

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory