Abraxas2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Abraxas2
BRISC complex subunit
MGI:1926116

25 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Abraxas2^tm1.2Bwng/Abraxas2⁺ involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl	enlarged spleen	J:245949
	increased lung adenocarcinoma incidence	J:245949
	increased lymphoma incidence	J:245949
	increased tumor incidence	J:245949
	premature death	J:245949
Abraxas2^tm1.2Bwng/Abraxas2^tm1.2Bwng involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl	abnormal cell nucleus morphology	J:245949
	abnormal chromosome morphology	J:245949
	abnormal DNA replication	J:245949
	abnormal mitosis	J:245949
	normal cellular phenotype	J:245949
	chromosomal instability	J:245949
	enlarged spleen	J:245949
	increased cellular sensitivity to DNA damaging agents	J:245949
	increased cellular sensitivity to ultraviolet irradiation	J:245949
	increased inflammatory response	J:245949
	increased lung adenocarcinoma incidence	J:245949
	increased lymphoma incidence	J:245949
	increased micronucleus incidence	J:245949
	increased sebaceous gland tumor incidence	J:245949
	increased tumor incidence	J:245949
	premature death	J:245949
Abraxas2^tm1Nju/Abraxas2^tm1Nju involves: C57BL/6J	abnormal enzyme/coenzyme activity	J:277205
	abnormal macrophage physiology	J:277205, J:363478
	decreased circulating interleukin-1 beta level	J:277205
	decreased inflammatory response	J:277205
	decreased interleukin-1 beta secretion	J:277205
	decreased interleukin-18 secretion	J:277205
	decreased protein level	J:363478
	decreased susceptibility to endotoxin shock	J:277205
	normal immune system phenotype	J:277205

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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