Abraxas2^tm1Nju
Targeted Allele Detail

Summary

• Symbol: Abraxas2^tm1Nju
• Name: BRISC complex subunit; targeted mutation 1, Model Animal Research Center of Nanjing University
• MGI ID: MGI:7545513
• Synonyms: Abro1^-
• Gene: Abraxas2 Location: Chr7:132460954-132486840 bp, + strand Genetic Position: Chr7, 76.32 cM
• Alliance: Abraxas2^tm1Nju page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:277205
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The targeting construct replaced part of exon 1 with a floxed neomycin resistance cassette. Immunoblot analysis confirmed the absence of protein expression in the heart, brain, liver and lung of homozygous mutant mice. (J:277205)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Abraxas2 Mutation: 25 strains or lines available

References

• Original: J:277205 Ren G, et al., ABRO1 promotes NLRP3 inflammasome activation through regulation of NLRP3 deubiquitination. EMBO J. 2019 Mar 15;38(6)
• All: 5 reference(s)