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Fbxo43 Gene Detail
Summary
  • Symbol
    Fbxo43
  • Name
    F-box protein 43
  • Synonyms
    4930533G20Rik, early mitotic inhibitor 2, Emi2, endogenous meiotic inhibitor 2, XErp1 homolog
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926053
    NCBI Gene: 78803
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:36150060-36164884 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 14.46 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    151 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926053
protein coding gene Chr15:36150060-36169940 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021790
protein coding gene Chr15:34529687-34544583 (-)
A/J MGP_AJ_G0021751
protein coding gene Chr15:33231892-33246717 (-)
AKR/J MGP_AKRJ_G0021729
protein coding gene Chr15:34151466-34166435 (-)
BALB/cJ MGP_BALBcJ_G0021757
protein coding gene Chr15:33237670-33252479 (-)
C3H/HeJ MGP_C3HHeJ_G0021532
protein coding gene Chr15:34121276-34136082 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022196
protein coding gene Chr15:35835299-35850164 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019734
protein coding gene Chr15:31044950-31059092 (-)
CAST/EiJ MGP_CASTEiJ_G0021048
protein coding gene Chr15:34524132-34538698 (-)
CBA/J MGP_CBAJ_G0021501
protein coding gene Chr15:36994400-37009215 (-)
DBA/2J MGP_DBA2J_G0021625
protein coding gene Chr15:33054412-33069210 (-)
FVB/NJ MGP_FVBNJ_G0021603
protein coding gene Chr15:32453923-32468715 (-)
LP/J MGP_LPJ_G0021694
protein coding gene Chr15:34431810-34446686 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021628
protein coding gene Chr15:40107262-40125414 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022219
protein coding gene Chr15:34306245-34321065 (-)
PWK/PhJ MGP_PWKPhJ_G0020792
protein coding gene Chr15:33071915-33087111 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020630
protein coding gene Chr15:34004349-34019073 (-)
WSB/EiJ MGP_WSBEiJ_G0021104
protein coding gene Chr15:34273916-34288695 (-)



Homology
more
  • Human Ortholog
    FBXO43, F-box protein 43
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FBXO43, F-box protein 43
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EMI2, ERP1, FBX43
  • Links
    NCBI Gene ID: 286151
    neXtProt AC: NX_Q4G163
    UniProt: Q4G163

  • Chr Location
    8q22.2; chr8:100133360-100150569 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 66393
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FBXO43
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit female and male infertility with arrested meiosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000048230 Ensembl Gene Model | MGI Sequence Detail 14825 C57BL/6J ±  kb
    transcript ENSMUST00000058643 Ensembl | MGI Sequence Detail 4035 Not Applicable  
    polypeptide ENSMUSP00000054125 Ensembl | MGI Sequence Detail 641 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 14
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 11
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:251984 Gopinathan L, et al., Emi2 Is Essential for Mouse Spermatogenesis. Cell Rep. 2017 Jul 18;20(3):697-708

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    03/13/2019
    MGI 6.13
    The Jackson Laboratory